| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this study, we confirmed the usefulness of exercise therapy in the treatment of depression and examined whether the antidepressant effect induced by exercise was related to inosine action via adenosine receptors. By rearing mice in a 6-divided cage, physical activity decreased to 50% of the normal level, which caused depressive behaviors. The onset of depressive behaviors was inhibited by making mice exercise at low-intensity regularly while rearing inactively. The administration of adenosine receptor inhibitors did not affect the improvement of depressive behaviors caused by exercise. These results suggested that inosine was not related to improving depressive behaviors caused by low-intensity exercise.
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