Psychological program development focusing on executive function of obsessive-compulsive disorder with autism spectrum disorder

• Project/Area Number: 16K04342
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical psychology
• Research Institution: Chiba University
• Principal Investigator: Nagaoka Maki 千葉大学, 子どものこころの発達教育研究センター, 特任研究員 (40757788)
• Co-Investigator(Kenkyū-buntansha): 大島 郁葉 千葉大学, 子どものこころの発達教育研究センター, 講師 (40625472) ; 平野 好幸 千葉大学, 子どものこころの発達教育研究センター, 教授 (50386843) ; 中川 彰子 千葉大学, 子どものこころの発達教育研究センター, 教授 (70253424)
• Project Period (FY): 2016-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 強迫症 / 自閉スペクトラム症 / 実行機能 / 認知行動療法 / 認知機能改善療法 / 強迫性障害 / 自閉症スペクトラム障害 / 心理療法

Outline of Final Research Achievements

Cognitive-behavioral therapy, including exposure and response prevention, is effective in treating obsessive-compulsive disorder. However, deficits in cognitive function, comorbid with autism spectrum disorders, and associated executive function dysfunction may affect the therapeutic effect of cognitive-behavioral therapy. As a result of investigating the factors that influence the therapeutic effect of obsessive-compulsive disorder, working memory, which is a part of executive function, and decreased communication ability, which is characteristic of autism spectrum disorder, affected for cognitive-behavioral therapy of obsessive-compulsive disorder. These results may help develop a psychological program focusing on the executive function of obsessive-compulsive disorder comorbid with autism spectrum disorders.

Academic Significance and Societal Importance of the Research Achievements

実行機能の一部であるワーキングメモリを測定する「語音整列」と自閉症スペクトラム指数の「コミュニケーション」の結果から、強迫症の認知行動療法の治療効果を推定できる可能性が示された。一方、抑うつと不安の重症度、強迫症のサブタイプ、および性別は強迫症の重症度の変化に影響していなかった。治療中に視覚補助を行うなど、不十分なワーキングメモリを補うことは治療に有益であり、臨床家がより効果的な治療方針を選択するのに役立つ可能性がある。

Research Products

• [Journal Article] Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder (2020)
  • Author(s): Hamatani S, Tsuchiyagaito A, Nihei M, Hayashi Y, Yoshida Y, Takahashi J, Okawa S, Arai H, Nagaoka M, Matsumoto K, Shimizu E, Hirano Y
  • Journal Title: BMC Psychiatry Volume: 20 Issue: 1 Pages: 433-433
  • DOI: 10.1186/s12888-020-02841-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effectiveness and cost effectiveness of Mindfulness-Based Cognitive Therapy for improving subjective well-being among healthy individuals: study protocol for a randomised controlled trial. (2020)
  • Author(s): Sado M, Kosugi T, Ninomiya A, Nagaoka M, Park S, Fujisawa D, Shirahase J, Mimura M.
  • Journal Title: JMIR Res Protoc Volume: epub ahead of print Issue: 5 Pages: e15892-e15892
  • DOI: 10.2196/15892
  • Peer Reviewed / Open Access
• [Journal Article] Reliability and validity of the Japanese version of the Obsessive-Compulsive Inventory-Revised (OCI-R). (2018)
  • Author(s): Koike H, Tsuchiyagaito A, Hirano Y, Oshima F, Asano K, Sugiura Y, Kobori O, Ishikawa R, Nishinaka H, Shimizu E, Nakagawa A.
  • Journal Title: Curr Psychol Volume: In press Issue: 1 Pages: 1-7
  • DOI: 10.1007/s12144-017-9741-2
  • Peer Reviewed / Open Access
• [Journal Article] White matter features associated with autistic traits in obsessive-compulsive disorder. (2018)
  • Author(s): Kuno M, Hirano Y, Nakagawa A, Asano K, Oshima F, Nagaoka S, Matsumoto K, Masuda Y, Iyo M, Shimizu E.
  • Journal Title: Frontiers in Psychiatry Volume: 9 Pages: 216-216
  • DOI: 10.3389/fpsyt.2018.00216
  • Peer Reviewed / Open Access
• [Journal Article] Long-term outcome of CBT in adults with OCD and comorbid ASD: A naturalistic follow-up study. (2018)
  • Author(s): Nakagawa A, Olsson N C, Hiraoka Y, Nishinaka H, Miyazaki T, Kato N, Nakatani E, Tomita M, Yoshioka K, Murakami S, Aoki S
  • Journal Title: Current Psychology Volume: - Issue: 6 Pages: 1763-1771
  • DOI: 10.1007/s12144-018-9952-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Internet-Based Cognitive Behavioral Therapy With Real-Time Therapist Support via Video Conference for Patients With Obsessive-Compulsive Disorder,Panic Disorder, and Social Anxiety Disorder.Pilot Single-Arm Trial (2018)
  • Author(s): Matsumoto K, Sutoh C, Asano K, Seki Y, Urao Y, Yokoo M, Takanashi R, Yoshida T, Tanaka M, Noguchi R, Nagata S, Oshiro K, Numata N, Hirose M, Yoshimura K, Nagai K, Sato Y, Kishimoto T, Nakagawa A, Shimizu E.
  • Journal Title: Journal of Medical Internet Research Volume: 20 Issue: 12 Pages: e12091-e12091
  • DOI: 10.2196/12091
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive-behavioral therapy for obsessive-compulsive disorder with and without autism spectrum disorder: gray matter differences associated with poor outcome. (2017)
  • Author(s): Tsuchiyagaito A, Hirano Y, Asano K, Oshima F, Nagaoka S, Takebayashi Y, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Front Psychiatry Volume: 8 Pages: 143-143
  • DOI: 10.3389/fpsyt.2017.00143
  • Peer Reviewed / Open Access
• [Presentation] マインドフルネス～概念、実践、そしてEnquiry～ (2020)
  • Author(s): 佐渡充洋、二宮朗、永岡麻貴、小杉哲平
  • Organizer: 第2０回日本認知療法・認知行動療法学会
• [Presentation] Correlations Between the Clinical Profiles and the Profile of the Wechsler Adult Intelligence Scale-III in Obsessive Compulsive Disorder (2019)
  • Author(s): Hamatani S, Nihei M, Hayashi Y, Tsuchiyagaito A, Nakagawa A, Shimizu E, Hirano Y
  • Organizer: 9th World Congress of Behavioural and Cognitive Therapies
• [Presentation] 認知行動療法の治療効果予測に向けて：脳画像研究からの検討 (2018)
  • Author(s): 平野好幸
  • Organizer: 日本認知・行動療法学会第44回大会
• [Presentation] 認知行動療法と脳画像 (2018)
  • Author(s): 平野好幸
  • Organizer: 第34回日本行動科学会ウィンターカンファレンス
  • Invited
• [Presentation] Neurostructural predictors of cognitive behavioral therapy (CBT) for obsessive-compulsive disorder: implications for the integration of neurofeedback training and CBT (2017)
  • Author(s): Tsuchiyagaito A, Hirano Y, Tazaki M, Nakagawa A
  • Organizer: 2017 ISNR Annual Conference
  • Int'l Joint Research
• [Presentation] OCD with and without ASD: Do differential brain alternative predict CBT outcomes? (2017)
  • Author(s): Tsuchiyagaito A, Hirano Y, Shimizu E, Nakagawa A
  • Organizer: 24th Annual OCD Conference
  • Int'l Joint Research
• [Presentation] Do neuropsychological test give a clue for ASD tendency in adult OCD patients? (2016)
  • Author(s): Haruko Miyata, Yoshiyuki Hirano, Fumiyo Oshima, Kenichi Asano, Junko Matsumoto, Maki Nagaoka, Haruna Koike, Eiji Shimizu, Akiko Nakagawa
  • Organizer: The 46th European Association of Behavioral and Cogniitive Therapies Congress
  • Place of Presentation: Stockholm Waterfront Congress Centre (Sweden)
• [Book] マインドフルネスを医学的にゼロから解説する本 (2018)
  • Author(s): 佐渡充洋、藤澤大介、永岡麻貴（分担執筆）他
  • Total Pages: 236
  • Publisher: 日本医事新報社
  • ISBN: 9784784947980
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター
  • URL: https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター:
  • URL: https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html
• [Remarks] 業績 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター
• [Remarks] 業績 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター
  • URL: http://www.m.chiba-u.ac.jp/class/rccmd/researcher/result.html