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Psychological program development focusing on executive function of obsessive-compulsive disorder with autism spectrum disorder

Research Project

Project/Area Number 16K04342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical psychology
Research InstitutionChiba University

Principal Investigator

Nagaoka Maki  千葉大学, 子どものこころの発達教育研究センター, 特任研究員 (40757788)

Co-Investigator(Kenkyū-buntansha) 大島 郁葉  千葉大学, 子どものこころの発達教育研究センター, 講師 (40625472)
平野 好幸  千葉大学, 子どものこころの発達教育研究センター, 教授 (50386843)
中川 彰子  千葉大学, 子どものこころの発達教育研究センター, 教授 (70253424)
Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords強迫症 / 自閉スペクトラム症 / 実行機能 / 認知行動療法 / 認知機能改善療法 / 強迫性障害 / 自閉症スペクトラム障害 / 心理療法
Outline of Final Research Achievements

Cognitive-behavioral therapy, including exposure and response prevention, is effective in treating obsessive-compulsive disorder. However, deficits in cognitive function, comorbid with autism spectrum disorders, and associated executive function dysfunction may affect the therapeutic effect of cognitive-behavioral therapy. As a result of investigating the factors that influence the therapeutic effect of obsessive-compulsive disorder, working memory, which is a part of executive function, and decreased communication ability, which is characteristic of autism spectrum disorder, affected for cognitive-behavioral therapy of obsessive-compulsive disorder. These results may help develop a psychological program focusing on the executive function of obsessive-compulsive disorder comorbid with autism spectrum disorders.

Academic Significance and Societal Importance of the Research Achievements

実行機能の一部であるワーキングメモリを測定する「語音整列」と自閉症スペクトラム指数の「コミュニケーション」の結果から、強迫症の認知行動療法の治療効果を推定できる可能性が示された。一方、抑うつと不安の重症度、強迫症のサブタイプ、および性別は強迫症の重症度の変化に影響していなかった。治療中に視覚補助を行うなど、不十分なワーキングメモリを補うことは治療に有益であり、臨床家がより効果的な治療方針を選択するのに役立つ可能性がある。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder2020

    • Author(s)
      Hamatani S, Tsuchiyagaito A, Nihei M, Hayashi Y, Yoshida Y, Takahashi J, Okawa S, Arai H, Nagaoka M, Matsumoto K, Shimizu E, Hirano Y
    • Journal Title

      BMC Psychiatry

      Volume: 20 Issue: 1 Pages: 433-433

    • DOI

      10.1186/s12888-020-02841-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effectiveness and cost effectiveness of Mindfulness-Based Cognitive Therapy for improving subjective well-being among healthy individuals: study protocol for a randomised controlled trial.2020

    • Author(s)
      Sado M, Kosugi T, Ninomiya A, Nagaoka M, Park S, Fujisawa D, Shirahase J, Mimura M.
    • Journal Title

      JMIR Res Protoc

      Volume: epub ahead of print Issue: 5 Pages: e15892-e15892

    • DOI

      10.2196/15892

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reliability and validity of the Japanese version of the Obsessive-Compulsive Inventory-Revised (OCI-R).2018

    • Author(s)
      Koike H, Tsuchiyagaito A, Hirano Y, Oshima F, Asano K, Sugiura Y, Kobori O, Ishikawa R, Nishinaka H, Shimizu E, Nakagawa A.
    • Journal Title

      Curr Psychol

      Volume: In press Issue: 1 Pages: 1-7

    • DOI

      10.1007/s12144-017-9741-2

    • Related Report
      2019 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] White matter features associated with autistic traits in obsessive-compulsive disorder.2018

    • Author(s)
      Kuno M, Hirano Y, Nakagawa A, Asano K, Oshima F, Nagaoka S, Matsumoto K, Masuda Y, Iyo M, Shimizu E.
    • Journal Title

      Frontiers in Psychiatry

      Volume: 9 Pages: 216-216

    • DOI

      10.3389/fpsyt.2018.00216

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term outcome of CBT in adults with OCD and comorbid ASD: A naturalistic follow-up study.2018

    • Author(s)
      Nakagawa A, Olsson N C, Hiraoka Y, Nishinaka H, Miyazaki T, Kato N, Nakatani E, Tomita M, Yoshioka K, Murakami S, Aoki S
    • Journal Title

      Current Psychology

      Volume: - Issue: 6 Pages: 1763-1771

    • DOI

      10.1007/s12144-018-9952-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Internet-Based Cognitive Behavioral Therapy With Real-Time Therapist Support via Video Conference for Patients With Obsessive-Compulsive Disorder,Panic Disorder, and Social Anxiety Disorder.Pilot Single-Arm Trial2018

    • Author(s)
      Matsumoto K, Sutoh C, Asano K, Seki Y, Urao Y, Yokoo M, Takanashi R, Yoshida T, Tanaka M, Noguchi R, Nagata S, Oshiro K, Numata N, Hirose M, Yoshimura K, Nagai K, Sato Y, Kishimoto T, Nakagawa A, Shimizu E.
    • Journal Title

      Journal of Medical Internet Research

      Volume: 20 Issue: 12 Pages: e12091-e12091

    • DOI

      10.2196/12091

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive-behavioral therapy for obsessive-compulsive disorder with and without autism spectrum disorder: gray matter differences associated with poor outcome.2017

    • Author(s)
      Tsuchiyagaito A, Hirano Y, Asano K, Oshima F, Nagaoka S, Takebayashi Y, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
    • Journal Title

      Front Psychiatry

      Volume: 8 Pages: 143-143

    • DOI

      10.3389/fpsyt.2017.00143

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] マインドフルネス~概念、実践、そしてEnquiry~2020

    • Author(s)
      佐渡充洋、二宮朗、永岡麻貴、小杉哲平
    • Organizer
      第20回日本認知療法・認知行動療法学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Correlations Between the Clinical Profiles and the Profile of the Wechsler Adult Intelligence Scale-III in Obsessive Compulsive Disorder2019

    • Author(s)
      Hamatani S, Nihei M, Hayashi Y, Tsuchiyagaito A, Nakagawa A, Shimizu E, Hirano Y
    • Organizer
      9th World Congress of Behavioural and Cognitive Therapies
    • Related Report
      2019 Research-status Report
  • [Presentation] 認知行動療法の治療効果予測に向けて:脳画像研究からの検討2018

    • Author(s)
      平野好幸
    • Organizer
      日本認知・行動療法学会第44回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 認知行動療法と脳画像2018

    • Author(s)
      平野好幸
    • Organizer
      第34回日本行動科学会ウィンターカンファレンス
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Neurostructural predictors of cognitive behavioral therapy (CBT) for obsessive-compulsive disorder: implications for the integration of neurofeedback training and CBT2017

    • Author(s)
      Tsuchiyagaito A, Hirano Y, Tazaki M, Nakagawa A
    • Organizer
      2017 ISNR Annual Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] OCD with and without ASD: Do differential brain alternative predict CBT outcomes?2017

    • Author(s)
      Tsuchiyagaito A, Hirano Y, Shimizu E, Nakagawa A
    • Organizer
      24th Annual OCD Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Do neuropsychological test give a clue for ASD tendency in adult OCD patients?2016

    • Author(s)
      Haruko Miyata, Yoshiyuki Hirano, Fumiyo Oshima, Kenichi Asano, Junko Matsumoto, Maki Nagaoka, Haruna Koike, Eiji Shimizu, Akiko Nakagawa
    • Organizer
      The 46th European Association of Behavioral and Cogniitive Therapies Congress
    • Place of Presentation
      Stockholm Waterfront Congress Centre (Sweden)
    • Related Report
      2016 Research-status Report
  • [Book] マインドフルネスを医学的にゼロから解説する本2018

    • Author(s)
      佐渡充洋、藤澤大介、永岡麻貴(分担執筆)他
    • Total Pages
      236
    • Publisher
      日本医事新報社
    • ISBN
      9784784947980
    • Related Report
      2018 Research-status Report
  • [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター

    • URL

      https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター:

    • URL

      https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 業績 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター

    • Related Report
      2017 Research-status Report
  • [Remarks] 業績 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター

    • URL

      http://www.m.chiba-u.ac.jp/class/rccmd/researcher/result.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-01-27  

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