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The neural basis of mode shift in decision making: the mechanism of its breakdown with the locus coeruleus as the starting point

Research Project

Project/Area Number 16K04429
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionFukushima Medical University

Principal Investigator

Iguchi Yoshio  福島県立医科大学, 医学部, 助教 (20452097)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords意思決定 / 青斑核 / ノルアドレナリン / 背側線条体 / 化学遺伝学 / イオンチャネル / オペラント学習 / 青斑核ノルアドレナリン投射系 / 前帯状皮質 / Ionotropic Receptors / イベルメクチン開閉性塩化物チャネル / 脳内微少透析法 / 線条体 / 道具的(オペラント)学習 / 目標指向性⇔習慣 / グルタミン-イベルメクチン開閉性塩化物チャネル / 道具的学習 / グルタミン酸開閉性塩化物イオンチャネル / ノルアドレナリン投射系 / 細胞種特異的活動操作 / ionotropic receptor / フェニル酢酸 / マイクロダイアリシス / 高速液体クロマトグラフィー / 前帯状皮質-背側線条体投射経路 / 青斑核ノルアドレナリン作動性ニューロン / ケモジェネティクス / イムノトキシン細胞標的法
Outline of Final Research Achievements

By the time we started this study, we had a working hypothesis: noradrenergic projection from the locus coeruleus (LC) to the anterior cingulate cortex is a switch for a mode of decision-making (goal-directed/habit) shift; this behavioral function is realized through the regulation of the functional balance between the medial and lateral parts of the dorsal striatum. In this study, we developed three basic technologies necessary to test this hypothesis: (i) techniques to manipulate the in vivo activity of the LC neurons; (ii)techniques to inhibit the in vivo activity of the catecholaminergic neurons of rodents; (iii) an evaluation system for decision control modes in rodents. These projects have progressed smoothly, and we will be able to conduct experiments in behavioral neuroscience by integrating these basic technologies.

Academic Significance and Societal Importance of the Research Achievements

中枢ノルアドレナリン(NE)系の活動操作のための基盤技術開発に成功し,今後はこれらを有機的に統合した仮説検証が可能になった。青斑核ニューロンの活動性が中程度の場合(生理的な条件),背側線条体内側部の機能が同外側部に比べて亢進し,意思決定は目標追跡モードで制御される;青斑核ニューロンの活動が高い場合と低い場合の両者(急性ストレス負荷時,あるいは慢性ストレス負荷の結果としてNEシナプス伝達がブレークダウンした状態)で背外側線条体は機能亢進を示し,意思決定は習慣モードに偏移する,と予想される。今後の仮説検証の過程で,意思決定に異常をきたす複数の疾患に共通した病態解明と,新たな治療法開発が期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (28 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (17 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results)

  • [Int'l Joint Research] Case Western Reserve University(The United States of America)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Sustaining temporal attention prevents habit expression during operant learning in rats.2020

    • Author(s)
      Lin Ziqiao, Nishikawa Hiromi, Iguchi Yoshio, Iwanami Akira, Kikuchi Mitsuru
    • Journal Title

      Scientif Reports

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal Neurons2019

    • Author(s)
      Kikuta Satomi、Iguchi Yoshio、Kakizaki Toshikazu、Kobayashi Kazuto、Yanagawa Yuchio、Takada Masahiko、Osanai Makoto
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 13 Pages: 1-9

    • DOI

      10.3389/fncel.2019.00547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced aversive memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons2019

    • Author(s)
      Fukabori Ryoji、Iguchi Yoshio、Kato Shigeki、Takahashi Kazumi、Eifuku Satoshi...Momiyama Toshihiko、Benton Richard、Kobayashi Kazuto
    • Journal Title

      bioRxiv

      Volume: --

    • DOI

      10.1101/831313

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models2018

    • Author(s)
      Arakawa, H., Iguchi, I.
    • Journal Title

      Neuroscience Research

      Volume: 135 Pages: 1-12

    • DOI

      10.1016/j.neures.2018.02.001

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ペラント条件づけ―基礎理論を学ぶ2018

    • Author(s)
      井口善生
    • Journal Title

      臨床心理学第18巻第1号―もっと知りたいあなたのための認知行動療法ガイド

      Volume: 18 Pages: 7-11

    • Related Report
      2017 Research-status Report
  • [Journal Article] Reduction, Comparison, and Development in the Study of Animal Psychology: Footprint of exploratory behaviors as a comparative psychologist2017

    • Author(s)
      辻 敬一郎, 井口 善生
    • Journal Title

      Japanese Journal of Animal Psychology

      Volume: 67 Issue: 2 Pages: 73-78

    • DOI

      10.2502/janip.67.2.1

    • NAID

      130006894381

    • ISSN
      0916-8419, 1880-9022
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of an unconventional process of instrumental learning characteristically initiated with outcome devaluation-insensitivity and generalized action selection.2017

    • Author(s)
      Iguchi Y, Lin Z, Nishikawa H, Minabe Y, Toda S
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 43307-43307

    • DOI

      10.1038/srep43307

    • NAID

      120005983032

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconsidering animal models of major depressive disorder in the elderly.2016

    • Author(s)
      Toda S, Iguchi Y, Ziqiao L, Nishikawa H, Nagasawa T, Watanabe H, Minabe Y
    • Journal Title

      Front Aging Neurosci.

      Volume: 8 Pages: 188-188

    • DOI

      10.3389/fnagi.2016.00188

    • NAID

      120005983031

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Development and application of the multimodal ultra-thin endoscope for analyzing neuronal circuits in the deep brain region.2019

    • Author(s)
      Osanai, M., Ohkawa, N., Iguchi, Y., Yokose, J., Nakayama, S., Inokuchi, K., Kobayashi, K., Haga, Y., & Mushiake, H.
    • Organizer
      Neural Oscillation Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Attempts to visualize neuronal activity by striatal cell type during various learning phases of stimulus discrimination.2019

    • Author(s)
      Iguchi, Y., & Kobayashi, K.
    • Organizer
      新学術領域研究「人工知能と脳科学」第7回領域会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] 目標指向行動の動機づけにおける腹側被蓋野D2受容体陽性ドーパミンニューロンの役割2019

    • Author(s)
      井口善生・中山義貴・加藤成樹・小林和人
    • Organizer
      福島県立医科大学研究連携セミナー2019年度ポスター発表会―学内研究の連携と活性化に向けて―
    • Related Report
      2019 Annual Research Report
  • [Presentation] Innately induced palatable feeding by dietary imbalance of essential fatty acids.2019

    • Author(s)
      Sakayori, N., Higuchi, O., Fukabori, R. Iguchi, Y., Setogawa, S., Eitsuka, T., Miyazawa, T., & Kobayashi, K.
    • Organizer
      The 42th Annual Meeting of the Japan Neuroscience Society (Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chemogenetic inhibition of ventral tegmental area dopamine neurons reveals multidimensional roles in motivated behavior reinforced by natural reward.2019

    • Author(s)
      Iguchi, Y., Kato, S., Nishizawa, K., & Kobayashi, K.
    • Organizer
      The 42th Annual Meeting of the Japan Neuroscience Society (Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Enhanced retrieval of learned emotional memory by chemogenetic activation of locus coeruleus noradrenergic neurons.2019

    • Author(s)
      Iguchi, Y., & Kobayashi, K.
    • Organizer
      The 19th Annual Meeting of JSNP
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 報酬学習の履歴とストレス反応性―行動と結果の随伴性の学習によるレジリエンス生起―2018

    • Author(s)
      井口善生
    • Organizer
      次世代脳プロジェクト冬のシンポジウム. 12月12-14日, 一橋大学一橋講堂, 東京.
    • Related Report
      2018 Research-status Report
  • [Presentation] Continuous attentional demand may prevent habit formation in rats.2018

    • Author(s)
      2.Lin, Z., Nishikawa, H., Iguchi, Y. Iwanami, A. Minabe, Y., & Toda, S.
    • Organizer
      The 41th Annual Meeting of the Japan Neuroscience Society, July 26-29, Kobe convention center, Hyogo, Japan.
    • Related Report
      2018 Research-status Report
  • [Presentation] Identification of indirect pathway neurons and dopaminergic innervation in the rat dorsomedial striatum.2018

    • Author(s)
      3.Nonomura, S., Kato, S., Iguchi, Y., Nishizawa, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Watanabe, M., Kobayashi, K., Isomura, Y., & Kimura, M.
    • Organizer
      The 41th Annual Meeting of the Japan Neuroscience Society, July 26-29, Kobe convention center, Hyogo, Japan.
    • Related Report
      2018 Research-status Report
  • [Presentation] オペラント行動の制御における線条体ニューロンの役割―意思決定の変調としての依存症理解への示唆―2018

    • Author(s)
      井口善生
    • Organizer
      平成30年度 アルコール・薬物依存関連学会合同学術総会, 9月8日-10日, 国立京都国際会館 京都.
    • Related Report
      2018 Research-status Report
  • [Presentation] New chemogenetic systems to investigate the role of neural circuit for adaptive behaviors2017

    • Author(s)
      井口善生
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] A chemogenetic approach to elucidate the role of the striatopallidal neurons in the performance of operant auditory discrimination2017

    • Author(s)
      Iguchi, Y., Nishizawa, K., Kato, K., & Kobayashi, K.
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Coordinated expression of learned motor behavior through striatofugal pathways2017

    • Author(s)
      Kobayashi, K., Iguchi, Y., & Nishizawa, K.
    • Organizer
      Symposium: Advances in Behavioral Neuroscience in Japan and Diversity of DAergic Regulation. 26th Annual Meeting of the International Behavioral Neuroscience Society (IBNS 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ストレスと意思決定の関係を分析する―ラットのオペラント学習を用いた検討2017

    • Author(s)
      井口善生
    • Organizer
      第6回東北脳科学ウインタースクール
    • Place of Presentation
      宮城県,ラフォーレ蔵王
    • Related Report
      2016 Research-status Report
  • [Presentation] 道具的学習の連合理論―習慣形成とその異常の機序解明に向けて―2016

    • Author(s)
      井口善生
    • Organizer
      日本認知・行動療法学会第42回大会
    • Place of Presentation
      徳島県,アスティとくしま
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] PETを用いた単一レバー押し課題中の学習依存的な神経活動の変化2016

    • Author(s)
      瀬戸川将・岡内隆・井口善生・和田康弘・林中恵美・疋島啓吾・崔翼龍・小林和人
    • Organizer
      第71回日本体力医学学会大会
    • Place of Presentation
      岩手県,いわて県民情報交流センター
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of neuronal ensembles in the entire striatum that coincides with the transition period from goal-directed to habitual during instrumental learning2016

    • Author(s)
      Lin, Z., Nishikawa, H., Kaneda, K., Iguchi, Y., Minabe, Y., Bruce, T.
    • Organizer
      Neuroscience 2016 (the 39th annual meeting of the Japan neuroscience society)
    • Place of Presentation
      神奈川県,パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Book] あの人はどうしてそうしてしまうの? 身近な7つの扉から入る心理学の世界 羽成隆司・河野和明(編)2018

    • Author(s)
      井口善生(分担執筆)
    • Total Pages
      224
    • Publisher
      ポラーノ出版
    • Related Report
      2018 Research-status Report
  • [Book] Chapter 4 学ぶの扉 羽成隆司・河野和明(編) あの人はどうしてそうしてしまうの? 身近な7つの扉から入る心理学の世界2018

    • Author(s)
      井口善生
    • Total Pages
      32
    • Publisher
      ポラーノ出版
    • ISBN
      477241603X
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-12-28  

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