• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Practical Applications and New Development of the Control Strategy of Infectious Diseases based on the Stochastic Approach

Research Project

Project/Area Number 16K06416
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Control engineering/System engineering
Research InstitutionYamaguchi University

Principal Investigator

Ishikawa Masaaki  山口大学, 大学院創成科学研究科, 教授 (30201916)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords感染症モデル / 確率システム / 安定性解析 / 最適制御 / 時間遅れ / リアプノフ指数 / ワクチン接種 / シミュレーション / 安定性 / 確率最大原理 / 平衡解 / 確率リヤプノフ定理 / リヤプノフ指数 / Disease-free平衡解 / シミュレーション解析 / 制御工学 / シミュレーション工学 / 応用数学 / 確率過程論 / 機械力学・制御
Outline of Final Research Achievements

In this research, we have established the feasible control strategy for the infectious disease based on the stochastic system theory. First, we have formulated the infectious model as the simultaneous time delayed stochastic differential equations by considering the random fluctuation in the infection and recovery rates. Secondly, by using the stochastic Lyapunov theorem, we have shown the sufficient condition for the disease-free steady state to be stable. It follows from the stability condition that we are able to know the necessary vaccination rate to control the infectious disease spreading. Finally, by calculating the Lyapunov exponent, we have clarified that the random fluctuation in the recovery and the infection rates have played a role to stabilize the disease-free steady state.
Furthermore, we have developed the new infectious model, i.e., the stochastic age-structured model.

Academic Significance and Societal Importance of the Research Achievements

学術的意義:以下の観点から感染症解析に対する工学的アプローチによる先駆的研究として意義がある.(1) 感染症モデルを確率システム理論に基づき構築したこと.(2) 感染症モデルに含まれる不規則外乱の影響を理論的に明らかにしたこと.(3) シミュレーションにより感染症抑制戦戦略の有効性を明らかにしたこと.

社会的意義:高度に医療技術が進歩した現代社会においても感染症の脅威は依然として存在しているが,本研究は感染症流行の抑制に必要なワクチン接種率の推定や感染症流行過程の予測などにも有効であり,本研究成果は安全かつ健全な社会構築に貢献するものである.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016

All Journal Article (15 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 6 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Stability Analyses of the Stochastic Delayed Infectious Models with Reinfection2019

    • Author(s)
      Masaaki Ishikawa
    • Journal Title

      ransactions of the Institute of Systems, Control and Information Engineers

      Volume: 32 Pages: 1-7

    • NAID

      130007632907

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On the Stability Analysis of the Stochastic Age-structured Infectious Model2019

    • Author(s)
      Masaaki Ishikawa
    • Journal Title

      Proceedings of the 50th International Symposium on Stochastic Systems Theory and Its Applications

      Volume: USB

    • NAID

      130007777092

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分布的時間遅れを考慮した確率感染症モデルの安定性解析2018

    • Author(s)
      石川 昌明
    • Journal Title

      システム制御情報学会論文誌

      Volume: 31 Pages: 129-136

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mathematical Analysis of the Stochastic Delayed Epidemic Model with Reinfection2018

    • Author(s)
      Masaaki Ishikawa
    • Journal Title

      Proceedings of the 49th International Symposium on Stochastic Systems Theory and Its Applications

      Volume: CD-ROM

    • NAID

      130007580071

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 確率システム理論に基づく感染症解析2018

    • Author(s)
      石川 昌明
    • Journal Title

      第62回システム制御情報学会研究発表講演会講演論文集

      Volume: 1

    • NAID

      40021554099

    • Related Report
      2017 Research-status Report
  • [Journal Article] Stability Analysis of the Stochastic Delayed Infectious Model with Vaccination2018

    • Author(s)
      M. Ishikawa
    • Journal Title

      Transactions of the Institute of Systems, Control and Information

      Volume: 31

    • NAID

      130006707952

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mathematical Analysis of the Stochastic Delayed Epidemic Model with Reinfection2018

    • Author(s)
      M. Ishikawa
    • Journal Title

      Proceedings of the 49th International Symposium on Stochastic Systems Theory and Its Applications

      Volume: 1

    • NAID

      130007580071

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stability Analysis of the Stochastic SIR Model with Discrete Delay2017

    • Author(s)
      M. Ishikawa
    • Journal Title

      Proceedings of the 48th International Symposium on Stochastic Systems Theory and Its Applications

      Volume: 1

    • NAID

      130006192993

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 感染症モデルとその解析2017

    • Author(s)
      石川 昌明
    • Journal Title

      第61回システム制御情報学会研究発表講演会講演論文集

      Volume: 1

    • NAID

      40021219940

    • Related Report
      2017 Research-status Report
  • [Journal Article] 時間遅れを考慮した確率SIRモデルの安定性解析2017

    • Author(s)
      石川 昌明
    • Journal Title

      システム制御情報学会論文誌

      Volume: 61 Pages: 115-121

    • NAID

      130005773964

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stability Analysis of the Stochastic SIR Model with Discrete Delay2017

    • Author(s)
      Masaaki Ishikawa
    • Journal Title

      Proceedings of the 48th International Symposium on Stochastic Systems Theory and Its Applications

      Volume: CD-ROM

    • NAID

      130006192993

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 非線形発生率を考慮した確率SIVモデルと最適ワクチン接種戦略2016

    • Author(s)
      石川 昌明
    • Journal Title

      システム制御情報学会論文誌

      Volume: 29 Pages: 168-174

    • NAID

      130005165104

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 時間遅れを伴う感染症モデルの安定性解析2016

    • Author(s)
      石川 昌明
    • Journal Title

      第59回自動制御連合講演会講演予稿集

      Volume: 1 Pages: 276-277

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 回復率の揺らぎを考慮した時間遅れを伴う感染症モデルの安定性解析2016

    • Author(s)
      石川 昌明
    • Journal Title

      日本応用数理学会2016年度年会講演予稿集

      Volume: CD-ROM

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 時間遅れを考慮した確率SIRモデルについて2016

    • Author(s)
      石川 昌明
    • Journal Title

      第60回システム制御情報学会研究発表講演会講演論文集

      Volume: CD-ROM

    • NAID

      40020835107

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 確率システム理論に基づく感染症解析2018

    • Author(s)
      石川 昌明
    • Organizer
      第62回システム制御情報学会研究発表講演会
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Presentation] On the Stability Analysis of the Stochastic Age-structured Infectious Model2018

    • Author(s)
      Masaaki Ishikawa
    • Organizer
      The 50th International Symposium on Stochastic Systems Theory and Its Applications
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mathematical Analysis of the Stochastic Delayed Epidemic Model with Reinfection2017

    • Author(s)
      M. Ishikawa
    • Organizer
      The 49th ISCIE International Symposium on Stochastic Systems Theory and Its Applications
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 感染症モデルとその解析2017

    • Author(s)
      石川 昌明
    • Organizer
      第61回システム制御情報学会研究発表講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 時間遅れを伴う感染症モデルの安定性解析2016

    • Author(s)
      石川 昌明
    • Organizer
      第59回自動制御連合講演会
    • Place of Presentation
      北九州国際会議場 (福岡県北九州市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Stability Analysis of the Stochastic SIR Model with Discrete Delay2016

    • Author(s)
      Masaaki Ishikawa
    • Organizer
      The 48th International Symposium on Stochastic Systems Theory and Its Applications
    • Place of Presentation
      Fukuoka Institute of Technology(福岡県福岡市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 回復率の揺らぎを考慮した時間遅れを伴う感染症モデルの安定性解析2016

    • Author(s)
      石川 昌明
    • Organizer
      日本応用数理学会2016年度年会
    • Place of Presentation
      北九州国際会議場 (福岡県北九州市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 時間遅れを考慮した確率SIRモデルについて2016

    • Author(s)
      石川 昌明
    • Organizer
      第60回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都テルサ (京都府京都市)
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi