| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Microbial production of various useful compounds has been reported using synthetic biology and metabolic engineering methods. To further expand the products, application of S-adenosylmethionine-dependent enzymes are important. Therefore, this study aimed to develop a platform for utilizing these enzymes. As the results, it was confirmed that phenylethanolamine-N-methyltransferase was useful for the verification. To avoid inhibition by the by-product S-adenosylhomocysteine, the degradation pathway of Escherichia coli could be used.
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