Modular network of marmoset PFC connection
Project/Area Number |
16K07036
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Watakabe Akiya 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (40290910)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | トレーサー / AAV / マーモセット / 大脳皮質 / 神経ネットワーク / コネクトーム / 神経解剖学 / マッピング / 霊長類 / ウイルスベクター / 前頭葉 |
Outline of Final Research Achievements |
Prefrontal cortex (PFC) is a brain region that developed well in primate lineages. Its expansion and qualitative changes enabled high cognitive functions of humans. The specific aim of this research is to clarify the modular connectivity of the corticocortical network, which I think is the key to understand PFC. Marmoset monkey was chosen as a model primate for neuroanatomical studies using viral tracers and serial two photon tomography, which achieved efficient whole brain imaging. Combined with histological techniques, the connectional properties of remote areas are being explored. For example, area 8aD receives inputs from the contralateral PFC and ipsilateral cingular area, but those inputs are separated as columnar modules. Such modular connectivity is considered to be a general property of PFC.
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Academic Significance and Societal Importance of the Research Achievements |
神経科学の一大目標はヒトの脳とその疾患を理解することである。現在、神経科学研究はマウスを使った研究が圧倒的に進んでいるが、そこから得られた知見がどの程度ヒトにあてはまるのかは、実は未知数である。実際、マウスを使った創薬が失敗する例も多い。私の研究は、ある意味でマウスとヒトをつなぐことを目指している。ヒトの脳はもちろんサルとも違うが、マウスよりは明らかに共通性が多い。マウス-サル-ヒトと、進化的な考察を加えることで、共通のルールと種を分けた違いを明らかにすれば、ヒト脳に対する理解はより深まる。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks2018
Author(s)
Ebina T, Masamizu Y, Tanaka YR, Watakabe A, Hirakawa R, Hirayama Y, Hira R, Terada S, Koketsu D, Hikosaka K, Mizukami H, Nambu A, Sasaki E, Yamamori Y, Matsuzaki M
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Journal Title
Nat Commun
Volume: 9
Issue: 1
Pages: 1879-1879
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys2018
Author(s)
Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, *Ushiba J, *Okano H
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Journal Title
Cell Rep
Volume: 24(8)
Issue: 8
Pages: 2191-2195
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Axonal Projections From the Middle Temporal Area in the Common Marmoset2018
Author(s)
Hiroshi Abe, Toshiki Tani, Hiromi Mashiko, Naohito Kitamura, Taku Hayami, Satoshi Watanabe, Kazuhisa Sakai, Wataru Suzuki, Hiroaki Mizukami, Akiya Watakabe, Tetsuo Yamamori and Noritaka Ichinohe
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Journal Title
Frontiers in Neuroanatomy
Volume: 12
Pages: 89-89
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Single-cell bioluminescence imaging of deep tissue in freely moving animals.2018
Author(s)
Iwano S, Sugiyama M, Hama H, Watakabe A, Hasegawa N, Kuchimaru T, Tanaka KZ, Takahashi M, Ishida Y, Hata J, Shimozono S, Namiki K, Fukano T, Kiyama M, Okano H, Kizaka-Kondoh S, McHugh TJ, Yamamori T, Hioki H, Maki S, Miyawaki A.
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Journal Title
Science
Volume: 359
Issue: 6378
Pages: 935-939
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] 3D reconstruction of brain section images for creating axonal projection maps in marmosets.2017
Author(s)
Abe H, Tani T, Mashiko H, Kitamura N, Miyakawa N, Mimura K, Sakai K, Suzuki W, Kurotani T, Mizukami H, Watakabe A, Yamamori T, Ichinohe N.
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Journal Title
J Neurosci Methods
Volume: 286
Pages: 102-113
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Mapping prefrontal connectivity of the common marmosets2019
Author(s)
Akiya Watakabe, Henrik Skibbe, Ken Nakae, Jian Wang1, Masafumi Takaji, Alexander Woodward, Junichi Hata4, Hideyuki Okano, Yoko Yamaguchi, Shin Ishii, Hiroaki Mizukami, Tetsuo Yamamori
Organizer
革新脳国際シンポジウムISBM2019
Related Report
Int'l Joint Research
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[Presentation] Mapping prefrontal connectivity of the common marmosets2019
Author(s)
Akiya Watakabe, Henrik Skibbe, Ken Nakae, Jian Wang1, Masafumi Takaji, Alexander Woodward, Junichi Hata4, Hideyuki Okano, Yoko Yamaguchi, Shin Ishii, Hiroaki Mizukami, Tetsuo Yamamori
Organizer
第8回マーモセット研究会大会
Related Report
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[Presentation] Columnar and diffuse connectivity of the marmoset PFC neurons2017
Author(s)
Akiya Watakabe, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Takashi Kawase, Henrik Skibbe, Ken Nakae, Yoko Yamaguchi, Shin Ishii, Tetsuo Yamamori
Organizer
北米神経学会
Related Report
Int'l Joint Research
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