| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
DAP12 is considered to work as a signal transduction chain of some ligand-binding receptors in microglia. Our study, using allodynia model of mice, revealed that DAP12 can regulate microglial activity both positively and negatively after injury. When DAP12 makes complex with TREM2, TREM2/DAP12 promotes microglial pro-inflammatory responses after injury, whereas Siglec-H/DAP12 complex suppresses. Furthermore, we demonstrated Siglec-H as a microglia-specific marker that discriminates microglia from brain macrophages and CNS-infiltrating monocytes.
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