| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. Mieap deficiency in ApcMin/+ and Gan mice is strikingly associated with the malignant progression of murine gastrointestinal tumors. Comprehensive micro array analysis and metabolism analysis using the tumor organization of these model mice was performed.Several hypotheses about the role in gastrointestinal tumorigenesis and development of the Mieap-mitochondria quality control were obtained.
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