| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
One of the basic principles of "immunity" is the diversification of antibody genes, which is one of the mechanism of infection defense symbolized by the fact that you never suffer from measles twice. We elucidated a part of the complex story, how antibody genes are efficiently recombined in vivo to create a defense system. The topoisomerase 1 (Top1) presents in all the cells and have both function of maintenance of the integrity of the genomic DNA and also of destabilization the genomic DNA. By our study it was discovered that AID expressed only in immune B cells regulates Top1 by suppressing its translation and achieves highly efficient and specific gene recombination of antibody genes to produce diversified antibody proteins.
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