| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Opn5 forms one of the photoreceptive protein, opsin, groups, whose genes are widely distributed in vertebrate genomes. We previously revealed that vertebrate Opn5 is classified into several subgroups and is diversified based on their molecular properties and tissue distribution patterns. In this study, we analyzed one of the subgroups, Opn5n, which is sensitive to visible light and is expressed in the photoreceptor cells. We constructed knock-out medaka fish line and revealed that the fish shows deficient morphological changes in dark-adapted and light-adapted retinas. In addition, we characterized the key amino acid residue(s) responsible for the visible light sensitivity in Opn5n.
|
