| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The effects of dietary composition on metabolic disorders induced by androgen action deficiencies were studied using rodent models.
(1) Male androgen receptor knockout mice exhibited obesity, glucose intolerance, and a reduced lifespan when fed a high-fat diet. The observed metabolic disorders were attributed to gut microbiota.
(2) Inhibition of fetal androgen action suppressed pancreatic β-cell development in male rats. The rats exhibited insulin defects and glucose intolerance when fed high-fat diets.
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