| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We investigated the function of lipid mediators in the regulation of obesity. We constructed adipose-specific prostaglandin (PG) D2 synthase gene knockout (PGDS-KO) mice and analyzed the effect in obesity. Body weight gain was suppressed about 20% and insulin sensitivity was improved in adipocyte-specific PGDS-KO mice under high fat-diet. Moreover, the expression of the inflammatory-related genes was repressed in these mice. Thus, these results indicate that inhibition of PGD2 synthesis in adipocytes contributes to suppress obesity and to improve insulin sensitivity.
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