| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To elucidate the common pathogenic mechanism of spinocerebellar ataxia, which is caused by various causal genes, we analyzed lipid droplets (LDs), which are organelles containing neutral lipids. When we expressed the causal proteins of SCA21, SCA34, SCA38 and SCA3 in HeLa cells, LDs were significantly decreased compared with the cells expressing wild-type proteins. On the other hand, LDs were significantly increased by the expression of SCA14-causing protein. These findings strongly suggest that disturbance of intracellular lipid metabolism would be a common molecular basis in the pathogenesis of SCA.
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