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Discovery of natural anticancer agents that inhibit cancer cells' tolerance to nutrition starvation and elucidation of their molecular mechanisms

Research Project

Project/Area Number 16K08319
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionUniversity of Toyama

Principal Investigator

Awale Suresh  富山大学, 学術研究部薬学・和漢系, 准教授 (00377243)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsPancreatic cancer / Drug discovery / PANC-1 / Antiausterity agent / metabolomics / molecular mechanism / natural products / pancreatic cancer / antiausterity strategy / drug discovery / NMR / biomarker / Antiausterity strategy / Drug Discovery / Natural products / Metabolomics / Biomarker / metbolomics / anti-austerity
Outline of Final Research Achievements

The project aimed to discover novel anti-cancer agents by employing an anti-austerity strategy and to elucidate the mechanism of action through protein and metabolome analysis. Extensive investigation on the anti-cancer activity of the active principals from the medicinal plants Ferula hezarlalehzarica, Ancistrocladus abbreviatus, Calotropis gigantea, Artemisia vulgaris, Anneslea fragrans, Ancistrocladus ealaensis, Bosenbergia pandurata、Uvaria dac, Chamaecyparis obtusa, Citrus hystrix, Derris scandens, Callistemon citrinus has been investigated. The investigation of the mechanism of action of the selected novel anticancer agents was accomplished. In particular, the novel compound, a 5,8-linked naphthyl isoquinoline alkaloid Ancistrolikokine E3 was discovered as a promising anticancer agent that eliminates cancer cells' tolerance to nutrient starvation. Ancistrolikokine E3 was found to inhibit Akt/mTOR/Autophagy Signaling Pathway and causes pancreatic cancer cell death.

Academic Significance and Societal Importance of the Research Achievements

本プ ロジェクトでは、査読付きの国際学術誌に27本の論文を発表し、国際招待講演4件、国際会議8件を含む46件の学会発表を行った。新規化合物Ancistrolikokine E3 は、栄養飢餓に対するがん細胞の耐性を除去する有望な抗がん剤であることが発見され た。この発見は、ACS(米国化学協会) により重要な発見として選ばれ、世界中の数千のニュースメディアにプレスリリースされた。約130の国際的なニュースメディアがこの発見を取り上げた。このプロジェクトで発見された化合物は、抗がん剤開発の潜在的な種を表しています。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (73 results)

All 2020 2019 2018 2017 2016

All Journal Article (27 results) (of which Int'l Joint Research: 27 results,  Peer Reviewed: 27 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (46 results) (of which Int'l Joint Research: 17 results,  Invited: 4 results)

  • [Journal Article] Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line2020

    • Author(s)
      Alilou M., Dibwe D.F., Schwaiger S., Khodami M., Troppmair J. Awale S., Stuppner H.
    • Journal Title

      Journal of Natural Products

      Volume: 83 Issue: 4 Pages: 1099-1106

    • DOI

      10.1021/acs.jnatprod.9b01109

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ancistrosecolines A-F, Unprecedented seco-Naphthylisoquinoline Alkaloids from the Roots of Ancistrocladus abbreviatus, with Apoptosis-Inducing Potential against HeLa Cancer Cells2020

    • Author(s)
      Shaimaa Fayez S., Bruhn T., Feineis D., Assi L.A., Awale S. Bringmann G.
    • Journal Title

      Journal of Natural Products

      Volume: 83 Issue: 4 Pages: 1139-1151

    • DOI

      10.1021/acs.jnatprod.9b01168

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity2020

    • Author(s)
      Nguyen M.T.T., Khang D.H., Nguyen, Dang P.H., Nguyen H.X., Awale S., Nguyen N.T.
    • Journal Title

      Journal of Natural Products

      Volume: 83 Issue: 2 Pages: 385-391

    • DOI

      10.1021/acs.jnatprod.9b00875

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells2020

    • Author(s)
      Kohyama A., Yokoyama R., Dibwe D.F., El-Mekkawy S., Meselhy M.R., Awale S., Matsuya Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Issue: 7 Pages: 126964-126964

    • DOI

      10.1016/j.bmcl.2020.126964

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sidechain diversification of grandifloracin allows identification of analogues with enhanced anti-austerity activity against human PANC-1 pancreatic cancer cells2020

    • Author(s)
      Alexander B.E., Sun S., Palframan M.J., Kociok-Kohhn G., Dibwe D.F., Watanabe S., Caggiano L., Awale S., Lewis S.E.
    • Journal Title

      ChemMedChem

      Volume: 15 Issue: 1 Pages: 125-135

    • DOI

      10.1002/cmdc.201900549

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical constituents from Artemisia vulgaris and their antiausterity activities against the PANC-1 human pancreatic cancer cell line2019

    • Author(s)
      Omar A.M., Dibwe D.F., Tawila A.M., Sun S., Kim M.J., Phrutivorapongkul A., Awale S.
    • Journal Title

      Natural Product Research

      Volume: 7 Issue: 22 Pages: 1-7

    • DOI

      10.1080/14786419.2019.1700246

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line2019

    • Author(s)
      Omar A.M., Dibwe D.F, Tawila A.M., Sun S., Phrutivorapongkul A., Awale S.
    • Journal Title

      Journal of Natural Products

      Volume: 82 Issue: 11 Pages: 3133-3139

    • DOI

      10.1021/acs.jnatprod.9b00735

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8′-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells2019

    • Author(s)
      Tshitenge D.T., Bruhn T., Feineis D., Schmidt D., Mudogo V., Kaiser M., Brun R., Wurthner F., Awale S., Bringmann G.
    • Journal Title

      Journal of Natural Products

      Volume: 82 Issue: 11 Pages: 3150-3164

    • DOI

      10.1021/acs.jnatprod.9b00755

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and synthesis of functionalized coumarins as potential anti-austerity agents that eliminates cancer cells' tolerance to nutrition starvation2019

    • Author(s)
      Awale S., Okada T., Dibwe D.F., Maruyama T., Takahara S., Okada T., Endo S., Toyooka N.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 14 Pages: 1779-1784

    • DOI

      10.1016/j.bmcl.2019.05.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ancistrolikokine E3, a 5,8-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway.2018

    • Author(s)
      Awale S., Dibwe D. F., Balachandran C., Fayez S. Li J., Feineis D., Lombe B.K. Bringmann G.
    • Journal Title

      Journal of Natural Products

      Volume: 81 Issue: 10 Pages: 2282-2291

    • DOI

      10.1021/acs.jnatprod.8b00733

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical constituents of Thai Citrus hystrix and their antiausterity activity against the PANC-1 human pancreatic cancer cell line.2018

    • Author(s)
      Sun S., Phrutivorapongkul A., Dibwe D. F., Balachandran C., Awale S.
    • Journal Title

      Journal of Natural Products

      Volume: 81 Issue: 8 Pages: 1877-1883

    • DOI

      10.1021/acs.jnatprod.8b00405

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells2018

    • Author(s)
      Fayez S. Li J., Feineis D., Assi L.K., Kaiser M., Brun R., Awale S., Bringmann G.
    • Journal Title

      Fitoterapia

      Volume: 131 Pages: 245-259

    • DOI

      10.1016/j.fitote.2018.11.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ancistroyafungines A-D, 5,8′- and 5,1′-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells2018

    • Author(s)
      Muyisa S., Lombe B.K., Feineis D., Dibwe D.F., Maharaj V., Awale S., Bringmann G.
    • Journal Title

      Fitoterapia

      Volume: 130 Pages: 6-16

    • DOI

      10.1016/j.fitote.2018.07.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A New Compound from the Rhizomes of Boesenbergia pandurata2018

    • Author(s)
      Do T.N.V., Nguyen H.X., Le T.H., Ngo T.M.T., Dang P.H., Phung N.H., Vo N.T., Nguyen D.M., Le N.H.T., Le T.T., Nguyen M.T.T, Awale S., Nguyen N.T.
    • Journal Title

      Nat. Prod. Commun

      Volume: 13 Pages: 739-740

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells2018

    • Author(s)
      Lombe B.K., Feineis D., Mudogo V., Brun R., Awale S, Bringmann G.
    • Journal Title

      RSC Advances

      Volume: 8 Issue: 10 Pages: 5243-525

    • DOI

      10.1039/c8ra00363g

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A New Alkenylphenol from The Propolis of Stingless Bee Trigona minor2018

    • Author(s)
      Nguyen H.X. , Do T.N.V., Nguyen N.T.T., Dang P.H., Tho L.H., Awale S., Nguyen N.T.T.
    • Journal Title

      Natural Products Communication

      Volume: 13 Pages: 69-70

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ancistrolikokines E-H and Related 5,8'-coupled Naphthylisoquinoline alkaloids from the Congolese Liana Ancistrocladus likoko with Antiausterity Activities against PANC-1 Human Pancreatic Cancer Cells2017

    • Author(s)
      Fayez S. Li J., Feineis D., Mudogo V., Awale S., Bringmann G.
    • Journal Title

      RSC Advances

      Volume: 7 Issue: 85 Pages: 53740-53751

    • DOI

      10.1039/c7ra11200a

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line2017

    • Author(s)
      Li J., Seupel R., Bruhn T., Feineis D., Kaiser M., Brun R., Mudogo V., Awale S., Bringmann G.
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Issue: 10 Pages: 2087-2817

    • DOI

      10.1021/acs.jnatprod.7b00650

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of potential antiausterity agents from the Japanese Cypress Chamaecyparis obtusa2017

    • Author(s)
      Dibwe D.F., Sun S., Ueda J., Balachandran C., Matsumoto K., Awale S.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 21 Pages: 4898-4903

    • DOI

      10.1016/j.bmcl.2017.09.034

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line2017

    • Author(s)
      Nguyen H.X., Nguyen M.T.T., Nguyen N.T., Awale S.
    • Journal Title

      . Nat. Prod.

      Volume: 80 Issue: 8 Pages: 2345-2352

    • DOI

      10.1021/acs.jnatprod.7b00375

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gardenifolins A-H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line2017

    • Author(s)
      Tshitenge D.T.,Feineis D., Awale S., Bringmann G.
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Issue: 5 Pages: 1604-1614

    • DOI

      10.1021/acs.jnatprod.7b00180

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells2017

    • Author(s)
      Chang H., Wang Y., Gao X., Song Z., Awale S., Han N., Liu Z., Yin J.
    • Journal Title

      Fitoterapia

      Volume: 121 Pages: 31-37

    • DOI

      10.1016/j.fitote.2017.06.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea2017

    • Author(s)
      Nguyen K.D.H., Dang P.H., Nguyen H.X., Nguyen M.T.T., Awale S., Nguyen N.T.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 13 Pages: 2902-2906

    • DOI

      10.1016/j.bmcl.2017.04.087

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Highly oxygenated antiausterity agents from the leaves of Uvaria dac.2017

    • Author(s)
      Awale S, Tawila AM, Dibwe DF, Ueda JY, Sun S, Athikomkulchai S, Balachandran C, Saiki I, Matsumoto K, Esumi H.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Issue: 9 Pages: 1967-1967

    • DOI

      10.1016/j.bmcl.2017.03.021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana2017

    • Author(s)
      Dang P.H., Nguyen H.X., Duong T.T.T, Tran T.K.T., Nguyen P.T., Vu T.K.T, Vuong H.C, Phan T.H.N, Nguyen M.T.T, Nguyen N.T, Awale S.
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Issue: 4 Pages: 1087-1095

    • DOI

      10.1021/acs.jnatprod.7b00006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line2017

    • Author(s)
      Nhan Trung Nguyen, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Dya Fita Dibwe, Hiroyasu Esumi, Suresh Awale
    • Journal Title

      Journal of Natural Products

      Volume: 80 Issue: 8 Pages: 141-148

    • DOI

      10.1021/acs.jnatprod.6b00381

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC‐1 Human Pancreatic Cancer Cell Line2016

    • Author(s)
      Hai Xuan Nguyen, Truong Nhat Van Do, Tho Huu Le, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Hiroyasu Esumi, Suresh Awale
    • Journal Title

      Journal of Natural Products

      Volume: 79 Issue: 1 Pages: 2053-2059

    • DOI

      10.1021/acs.jnatprod.6b00784

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Discovery of potential antiausterity agents from Thai Kaempferia parviflora2019

    • Author(s)
      Sijia Sun, Dya Fita Dibwe, Ahmed M. Tawila, Ashraf M. Omar, Sirivan Athikomkulchai, Suresh Awale
    • Organizer
      日本生薬学会第66回年会; 2019 Sept 22-23; 東京.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antiausterity constituents from Callistemon citrinus2019

    • Author(s)
      Ahmed M. Tawila, Dya Fita DibweAshraf M. Omar, Sijia Sun, Suresh Awale
    • Organizer
      日本生薬学会第66回年会; 2019 Sept 22-23; 東京.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chemical Constituents from Anneslea fragransand Their Antiausterity Activity against the PANC-1 Pancreatic Cancer Cell Line2019

    • Author(s)
      Ashraf M. Omar, Dya Fita Dibwe, Ahmed M. Tawila, Sijia Sun, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      日本生薬学会第66回年会; 2019 Sept 22-23; 東京.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antiausterity activity against pancreatic cancer cells and antiplasmodial properties of naphthylisoquinoline alkaloids and their analogues2019

    • Author(s)
      Vinesh Maharaj, Severin Muyisa Kavatsurwa, William Shamburger, Phanankosi Moyo, Raina Seupel, Lyn-Marie Birkholtz, Gerhard Bringmann, Blaise Kimbadi Lombe, Suresh Awale
    • Organizer
      67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); 2019 Sept1-5; Innsbruck, Austria
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ステロイド系天然物 Guggulsterone の類縁体合成と抗癌性医薬シーズ探索に向けた 薬理活性評価2019

    • Author(s)
      高山亜紀、横山玲、志内玲彩、周越、櫻井宏明 、Suresh Awale、Meselhy R. M. Zayed、松谷裕二
    • Organizer
      第45回反応と合成の進歩シンポジウム; 2019 Oct 28-29; 倉敷.
    • Related Report
      2019 Annual Research Report
  • [Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2019

    • Author(s)
      西川裕也、乾貴信、岡田卓哉、Dya F. Dibwe、Suresh Awale、豊岡尚樹
    • Organizer
      2019年度有機合成化学北陸セミナー 金沢.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Constituents of Callistemon citrinus and Their Antiausterity Activities against Human Pancreatic Cancer Cell Line2019

    • Author(s)
      Ahmed M. Tawila, Ashraf M. Omar, Dia Fita Dibwe, Suresh Awale.
    • Organizer
      日本薬学会第139年会, 2019年3月20日~ 23日
    • Related Report
      2018 Research-status Report
  • [Presentation] Chemical Constituents from Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.2019

    • Author(s)
      Ashraf M. Omar, Dia Fita Dibwe, Ahmed M. Tawila, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      日本薬学会第139年会, 2019年3月20日~ 23日
    • Related Report
      2018 Research-status Report
  • [Presentation] Discovery of potential antiausterity agents from Thai Piper ribesoides2019

    • Author(s)
      Wasinee Su-Authai, Dya Fita Dibwe, Ashraf M. Omar, Orawan Monthakantirat, Supawadee Daodee, Yaowared Chulikhit, Suresh Awale
    • Organizer
      日本薬学会第139年会, 2019年3月20日~ 23日
    • Related Report
      2018 Research-status Report
  • [Presentation] Ancistrolikokine E3, a new naphthylisoquinoline alkaloid with potent activity against pancreatic cancer cells.2018

    • Author(s)
      S. Fayez, D. Feineis, B. K. Lombe, D. F. Dibwe, C. Balachandran, S. Awale, G. Bringmann.
    • Organizer
      Chemie-Symposium der Studierenden Mainfrankens 2018 Dec.6; Wuerzburg, Germany.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis of novel coumarin derivatives directed toward anti-pancreatic cancer agent based on anti-austerity strategy.2018

    • Author(s)
      Takahiro Okada, Satoyuki Takahara, Takuya Okada, Suresh Awale, Dya Fita Dibwe, Satoshi Endo, Naoki Toyooka.
    • Organizer
      36th Medicinal Chemistry Symposium MCS2018, 2018年9月28日~30日
    • Related Report
      2018 Research-status Report
  • [Presentation] Discovery of anti-austerity agents from Derris scandens.2018

    • Author(s)
      Dya Fita Dibwe, Haruka Fujino, Mio Aoike, Nusrin Pongterdsak, Ampai Phrutivorapongkul, Suresh Awale.
    • Organizer
      日本生薬学会第65回年会, 2018年9月17日~18日
    • Related Report
      2018 Research-status Report
  • [Presentation] Inspired by Nature: Synthesis of Plumbagin Derivatives as Potential Anti-austerity Agents.2018

    • Author(s)
      Suresh Awale, Dya Fita Dibwe, Naoki Toyooka.
    • Organizer
      Toyama Academic Gala, 2018年9月14日
    • Related Report
      2018 Research-status Report
  • [Presentation] Discovery of anti-austerity agents from Derris scandens.2018

    • Author(s)
      Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      Toyama Academic Gala, 2018年9月14日
    • Related Report
      2018 Research-status Report
  • [Presentation] Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against Human Pancreatic Cancer Cell Lines2018

    • Author(s)
      Sijia Sun, Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (3rd TAA-Pharm Symposium); 2018 Sept. 10-12; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Constituents of Anneslea fragrans and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.2018

    • Author(s)
      Ashraf M. Omar, Ahmed M. Tawila, Dibwe Dya Fita, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (3rd TAA-Pharm Symposium); 2018 Sept. 10-12; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Constituents of Callistemon citrinus and Their Antiausterity Activities against Human Pancreatic Cancer Cell Lines2018

    • Author(s)
      Ahmed M. Tawila, Ashraf M. Omar, Dibwe Dya Fita, Suresh Awale
    • Organizer
      The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (3rd TAA-Pharm Symposium); 2018 Sept. 10-12; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anticancer Drug Discovery: Strategy and Leads from Medicinal Plants2018

    • Author(s)
      Suresh Awale
    • Organizer
      Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Prenylated isoflavones from Thai Derris scandens and their antiausterity activity.2018

    • Author(s)
      Dya FIta Dibwe, Haruka Fujino, Mio Aoike, Nusrin Pongterdsak, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discovery of potential antiausterity agents from Thai Citrus hystrix2018

    • Author(s)
      Sijia Sun, Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chemical Constituents from Anneslea fragrans and their antiausterity activity against the PANC-1 human pancreatic cancer cell line.2018

    • Author(s)
      Ashraf M. Omar, Ahmed M. Tawila, Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Antiausterity activity of isopanduratin-A and its mechanism of action against PANC-1 human pancreatic cancer cells2018

    • Author(s)
      Chandrasekar Balachandran, Dya Fita Dibwe, Suresh Awale
    • Organizer
      日本薬学会第138年会、2018年03月25日~2018年03月28日 (金沢)
    • Related Report
      2017 Research-status Report
  • [Presentation] Furanocoumarins from the peels of Citrus hystrix and their antiausterity activity against three human pancreatic cancer cell lines2018

    • Author(s)
      Sijia Sun, Dya Fita Dibwe, Chandrasekar Balachandran, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      日本薬学会第138年会、2018年03月25日~2018年03月28日 (金沢)
    • Related Report
      2017 Research-status Report
  • [Presentation] Discovery of potential antiausterity agents from Thai Derris scandens2018

    • Author(s)
      Dya Fita Dibwe, Nusrin Pongterdsak, Kritsaya Chaithatwatthana, Ampai Phrutivorapongkul, Ahmed M. Tawila, Chandrasekar Balachandran, Suresh Awale
    • Organizer
      日本薬学会第138年会、2018年03月25日~2018年03月28日 (金沢)
    • Related Report
      2017 Research-status Report
  • [Presentation] ベトナム産スオウCaesalpinia sappan種子の新規cassane型ジテルペン2017

    • Author(s)
      Suresh Awale, Jun-ya Ueda, Dya FIta Dibwe, Hai Xuan Nguyen, Mai Thanh Thi Nguyen
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Chemical constituents of Citrus hystrix and their antiausterity activity against the PANC-1 human pancreatic cancer cell line2017

    • Author(s)
      Sijia Sun, Ampai Phrutivorapongkul, Dya Fita Dibwe, Suresh Awale
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Cadinane-type sesquiterpenes from Chamaecyparis obtusa and their antiausterity activity2017

    • Author(s)
      Dya Fita Dibwe, Sijia Sun, Jun-ya Ueda, Matsumoto K., Suresh Awale
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] The story of arctigenin: a leading anti-pancreatic cancer agent from Kampo medicine2017

    • Author(s)
      Suresh Awale
    • Organizer
      The 90th Annual meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Nagasaki
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Thai indigenous vegetables and condiments as a potential source of anti-pancreatic cancer agents2017

    • Author(s)
      Ampai Phrutivorapongkul, Dya Fita Dibwe, Sijia Sun, Suresh Awale
    • Organizer
      The 2nd International Conference on Herbal and Traditional Medicine
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2017-01-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discovery of natural anti-cancer agents targeting cancer cells' tolerance to nutrition starvation2017

    • Author(s)
      Suresh Awale, Dya Fita Dibwe
    • Organizer
      The 19th Takeda Science Foundation Symposium on Bioscience "Chronic Inflammation - Initiation, Progression and Resolution"
    • Place of Presentation
      Osaka
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Brazilian Green Propolis as the Source for anti-pancreatic cancer agents2017

    • Author(s)
      Dya Fita Dibwe, Sijia Sun, Jun-ya Ueda, Suresh Awale
    • Organizer
      The 19th Takeda Science Foundation Symposium on Bioscience "Chronic Inflammation - Initiation, Progression and Resolution"
    • Place of Presentation
      Osaka
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Application of NMR metabolomics in understanding the physiological target of Kampo medicine2017

    • Author(s)
      Suresh Awale
    • Organizer
      第7回 和漢研・熱研ジョイントセミナー、2017年12月4日(長崎)
    • Related Report
      2017 Research-status Report
  • [Presentation] Bergamottin, an anti-austerity agent from Citrus hystrix induced autophagy mediated PANC-1 cell death2017

    • Author(s)
      Sijia Sun, Dya Fita Dibwe, Chandrasekar Balachandran, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      International Symposium on Scientific Research of Traditional Medicine、2017年11月10 日 (Toyama)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on the anti-austerity activity of Derris scandens extract against the PANC-1 human pancreatic cancer cell line2017

    • Author(s)
      Nusrin Pongterdsak, Kristaya Chaithatwatthana, Ampai Phrutivorapongkul, Sijia Sun, Ahmed M. Tawila, Ashraf M. Omar, Chandrasekar Balachandran, Dya Fita Dibwe, Suresh Awale.
    • Organizer
      International Symposium on Scientific Research of Traditional Medicine、2017年11月10 日 (Toyama)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anti-austerity activity of Piper betle extract against the PANC-1 human pancreatic cancer cell line2017

    • Author(s)
      Kristaya Chaithatwatthana, Nusrin Pongterdsak, Ampai Phrutivorapongkul, Sijia Sun, Ashraf M. Omar, Ahmed M. Tawila, Chandrasekar Balachandran, Dya Fita Dibwe, Suresh Awale.
    • Organizer
      International Symposium on Scientific Research of Traditional Medicine、2017年11月10 日 (Toyama)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis and evaluation of preferential cytotoxicity under nutrient-deprived conditions of plumbagin derivatives2017

    • Author(s)
      Takahiro Maruyama, Takahiro Okada, Takuya Okada, Satoyuki Takahara, Chandrashaker Balachandran, Dya Fita Dibwe, Suresh Awale, Naoki Toyooka
    • Organizer
      The 35th Medicinal Chemistry Symposium, 2017年03月25日 ~2017年03月27日 (Nagoya)
    • Related Report
      2017 Research-status Report
  • [Presentation] Discovery of potential anticancer agents from the Japanese cypress “Hinoki”2017

    • Author(s)
      Suresh Awale
    • Organizer
      Toyama Academic GALA 2017, 2017年9月27 日 (Toyama).
    • Related Report
      2017 Research-status Report
  • [Presentation] Chemical Constituents of Piper longum and their Antiausterity activity2017

    • Author(s)
      Dya Fita Dibwe, Suresh Awale
    • Organizer
      Toyama Academic GALA 2017, 2017年9月27 日 (Toyama).
    • Related Report
      2017 Research-status Report
  • [Presentation] Discovery of antiausterity strategy based anticancer agents from Citrus hystrix DC.2017

    • Author(s)
      Sijia Sun, Dya Fita Dibwe, Chandrasekar Balachandran, Ampai Phrutivorapongkul, Suresh Awale
    • Organizer
      Toyama Academic GALA 2017, 2017年9月27 日 (Toyama).
    • Related Report
      2017 Research-status Report
  • [Presentation] Discovery of natural anti-cancer agents targeting cancer cells’ tolerance to nutrition starvation2017

    • Author(s)
      Suresh Awale
    • Organizer
      he 1st International Conference on Natural Medicine (ICNM2017), "From Local Wisdom to International Research", 2017年8月5日 ~2017年8月6日 (Bangkok, Thailand)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent advances in antiausterity strategy guided anticancer drug discoveries2016

    • Author(s)
      Suresh Awale
    • Organizer
      The 5th International Symposium on Bioactivities and Disease Prevention of Phytochemicals and Natural Products for Health
    • Place of Presentation
      National Chiayi University, Taiwan
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of Thai indigenous vegetables and condiments as a source for anti-pancreatic cancer agents2016

    • Author(s)
      Ampai Phrutivorapongkul, Sijia Sun, Dya Fita Dibwe, Suresh Awale
    • Organizer
      第21回日本フードファクター学会 学術集会
    • Place of Presentation
      富山
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Tomocins A-D, new cassane diterpenes from the seed kernels of Caesalpinia sappan2016

    • Author(s)
      Suresh Awale, Dya Fita Dibwe, Jun-ya Ueda, Hai Xuan Nguyen, Mai Thanh Thi Nguyen
    • Organizer
      日本生薬学会第63回年会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Chemical Constituents of Mangifera indica and Their Anti Austerity Activity against the PANC-1 Human Pancreatic Cancer Cell Line2016

    • Author(s)
      Hai Xuan Nguyen, Suresh Awale
    • Organizer
      The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network
    • Place of Presentation
      Toyama
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Potential Anticancer Agents from the Wood of Chamaecyparis obtusa2016

    • Author(s)
      Dya Fita Dibwe, Suresh Awale
    • Organizer
      The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network,
    • Place of Presentation
      Toyama
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Advances in antiausterity strategy based anticancer drug discoveries2016

    • Author(s)
      Suresh Awale
    • Organizer
      he 2016 Joint Symposium of The Natural Products Research Institute at Seoul National University and The Institute of Natural Medicine at University of Toyama
    • Place of Presentation
      Toyama
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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