| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Intratumoral blood vessels support cancer cell proliferation by supplying sufficient oxygen and nutrients, and provide cancer cells with a pathway for metastasis. In this study, we revealed that transcription factor Dach1 expression might promote tumor growth and angiogenesis in tumors. We found that tumor with an increased number of blood vessels grow more vigorously in the mice that constantly expressing Dach1 (Dach1-Tg) compared with wild-type. By a fow cytometric analysis using reporter mice that specifically express mTFP1 in vascular endothelial cells, we compared the percentages of endothelial cells in Dach1-Tg- and wild-type-derived tumors.
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