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Dysfunction in relationships between muscle and bone in obesity

Research Project

Project/Area Number 16K08534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionKindai University

Principal Investigator

KAWAO Naoyuki  近畿大学, 医学部, 講師 (70388510)

Co-Investigator(Kenkyū-buntansha) 梶 博史  近畿大学, 医学部, 教授 (90346255)
Research Collaborator MORITA hironobu  
OKUMOTO katsumi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords骨粗鬆症 / サルコペニア / 筋骨連関 / 肥満 / 脂肪 / メカニカルストレス / アディポカイン / 筋骨連携 / アイリシン / 筋・骨連携 / 環境生理学
Outline of Final Research Achievements

We aimed to investigate the humoral factors linking muscle to bone induced by mechanical stress and effects of obesity on the relationships between muscle and bone. We found that hypergravity increased follistatin levels in skeletal muscle. Follistatin may have beneficial effects on bone metabolism as a humoral factor linking muscle to bone. Moreover, we reported that mechanical unloading reduced irisin expression in the skeletal muscle of mice and irisin may contribute to disuse-induced bone loss in mice. We also found that obesity enhances the recovery of bone and muscle masses as well as strength decreased by disuse after reloading in mice. Leptin may be involved in the recovery of muscle and bone enhanced by obesity in mice.

Academic Significance and Societal Importance of the Research Achievements

超高齢社会を迎えた我が国において、健康寿命を著しく損なう骨粗鬆症や筋量と筋機能の両方が低下するサルコペニアへの対応が臨床的に喫緊の問題となっており、高齢者医療の現状と医療経済的な面を鑑みると、サルコペニアと骨粗鬆症の両者に有効な薬剤の開発が必要である。骨粗鬆症とサルコペニアの病因には共通したメカニズムの存在が推定されているが、これには筋と骨のネットワーク機構の関与が示唆されている。本研究より得られた成果は、骨粗鬆症とサルコペニアに共通した新しい病態機序の解明の手掛かりとなり、将来的には骨粗鬆症とサルコペニアの診断に有用な血中マーカーや治療標的の確立に繋がることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017 2016 Other

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Plasminogen activator inhibitor‐1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice2018

    • Author(s)
      Takafuji Yoshimasa、Tatsumi Kohei、Ishida Masayoshi、Kawao Naoyuki、Okada Kiyotaka、Matsuo Osamu、Kaji Hiroshi
    • Journal Title

      Journal of Cellular Physiology

      Volume: 234 Issue: 6 Pages: 9687-9697

    • DOI

      10.1002/jcp.27655

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serpina3n, dominantly expressed in female osteoblasts, suppresses the phenotypes of differentiated osteoblasts in mice.2018

    • Author(s)
      Ishida M, Kawao N, Okada K, Tatsumi K, Sakai K, Nishio K, Kaji H.
    • Journal Title

      Endocrinology

      Volume: 159 Pages: 3775-3790

    • DOI

      10.1210/en.2018-00639

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasminogen activator inhibitor-1 is involved in interleukin-1β-induced matrix metalloproteinase expression in murine chondrocytes.2018

    • Author(s)
      Moritake A, Kawao N, Okada K, Ishida M, Tatsumi K, Matsuo O, Akagi M, Kaji H.
    • Journal Title

      Mod Rheumatol

      Volume: 28 Issue: 6 Pages: 1-5

    • DOI

      10.1080/14397595.2018.1525018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair.2018

    • Author(s)
      Okada K, Kawao N, Tatsumi K, Ishida M, Takafuji Y, Kurashimo S, Okumoto K, Kojima K, Matsuo O, Kaji H.
    • Journal Title

      Bone Rep

      Volume: 8 Pages: 195-203

    • DOI

      10.1016/j.bonr.2018.04.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Macrophages and Plasminogen Activator Inhibitor-1 in Delayed Bone Repair in Diabetic Female Mice2018

    • Author(s)
      Shimoide Takeshi、Kawao Naoyuki、Tamura Yukinori、Okada Kiyotaka、Horiuchi Yoshitaka、Okumoto Katsumi、Kurashimo Shinji、Ishida Masayoshi、Tatsumi Kohei、Matsuo Osamu、Kaji Hiroshi
    • Journal Title

      Endocrinology

      Volume: 159 Issue: 4 Pages: 1875-1885

    • DOI

      10.1210/en.2018-00085

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice2018

    • Author(s)
      Kawao N, Moritake A, Tatsumi K, Kaji H
    • Journal Title

      Calcified Tissue International

      Volume: - Issue: 1 Pages: 24-34

    • DOI

      10.1007/s00223-018-0387-3

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of follistatin in muscle and bone alterations induced by gravity change in mice.2018

    • Author(s)
      Kawao N, Morita H, Obata K, Tatsumi K, Kaji H.
    • Journal Title

      J Cell Physiol.

      Volume: 233 Issue: 2 Pages: 1191-1201

    • DOI

      10.1002/jcp.25986

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice.2017

    • Author(s)
      Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H.
    • Journal Title

      J Physiol Sci.

      Volume: - Issue: 5 Pages: 609-616

    • DOI

      10.1007/s12576-017-0566-4

    • NAID

      40021645358

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice.2017

    • Author(s)
      Moritake A, Kawao N, Okada K, Tatsumi K, Ishida M, Okumoto K, Matsuo O, Akagi M, Kaji H.
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 18 Issue: 1 Pages: 392-392

    • DOI

      10.1186/s12891-017-1752-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The vestibular system is critical for the changes in muscle and bone induced by hypergravity2016

    • Author(s)
      Kawao N, Morita H, Obata K, Tamura Y, Okumoto K and Kaji H
    • Journal Title

      Physiological Reports

      Volume: 4(19) Issue: 19 Pages: 12979-12979

    • DOI

      10.14814/phy2.12979

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel roles of FKBP5 in muscle alteration induced by gravity change in mice2016

    • Author(s)
      Shimode T, Kawao N, Tamura Y, Morita H and Kaji H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 479 Issue: 3 Pages: 602-606

    • DOI

      10.1016/j.bbrc.2016.09.126

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Roles of macrophages and PAI-1 in diabetic delayed bone repair in female mice.2019

    • Author(s)
      Kawao N,Shimoide T,Tamura Y,Okada K, Okumoto K, Kurashimo S,Horiuchi Y, Tatsumi K, Matsuo O,Kaji H.
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メカニカルストレスが筋・骨連関に及ぼす影響におけるアイリシンの役割.2018

    • Author(s)
      河尾直之、森竹章公、辰巳公平、石田昌義、高藤義正、梶 博史.
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 変形性膝関節症病態の軟骨下骨減少におけるPAI-1の役割2018

    • Author(s)
      河尾直之、森竹章公、岡田清孝、奥本勝美、辰巳公平、松尾 理、赤木將男、梶 博史.
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of irisin in interactions between muscle and bone during mechanical unloading in mice.2018

    • Author(s)
      河尾直之、森竹章公、辰巳公平、石田昌義、高藤義正、梶博史
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Role of follistatin in alterations of muscle and bone induced by hypergravity via the vestibular system in mice.2017

    • Author(s)
      河尾直之、森田啓之、小畑孝二、辰巳公平、石田昌義、梶 博史.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 重力変化が抗重力筋と骨の遺伝子発現におよぼす影響と前庭系の関与2017

    • Author(s)
      河尾直之、森田啓之、西田一晃、小畑孝二、石田昌義、辰巳公平、梶博史
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 重力変化により誘導される新規因子FKBP5の骨格筋における役割2017

    • Author(s)
      河尾直之、下出孟史、田村行識、高藤義正、石田昌義、辰巳公平、森田啓之、梶博史
    • Organizer
      第4回日本サルコペニア・フレイル学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 重力変化の前庭系を介する筋・骨への影響におけるフォリスタチンの役割.2016

    • Author(s)
      河尾直之、森田啓之、小畑孝二、田村行識、梶 博史.
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Remarks] 近畿大学 医学部 再生機能医学講座

    • URL

      https://www.med.kindai.ac.jp/physio2/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 近畿大学 医学部 再生機能医学講座

    • URL

      http://www.med.kindai.ac.jp/physio2/

    • Related Report
      2017 Research-status Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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