Dysfunction in relationships between muscle and bone in obesity
| Project/Area Number |
16K08534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梶 博史 近畿大学, 医学部, 教授 (90346255)
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| Research Collaborator |
MORITA hironobu
OKUMOTO katsumi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨粗鬆症 / サルコペニア / 筋骨連関 / 肥満 / 脂肪 / メカニカルストレス / アディポカイン / 筋骨連携 / アイリシン / 筋・骨連携 / 環境生理学 |
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| Outline of Final Research Achievements |
We aimed to investigate the humoral factors linking muscle to bone induced by mechanical stress and effects of obesity on the relationships between muscle and bone. We found that hypergravity increased follistatin levels in skeletal muscle. Follistatin may have beneficial effects on bone metabolism as a humoral factor linking muscle to bone. Moreover, we reported that mechanical unloading reduced irisin expression in the skeletal muscle of mice and irisin may contribute to disuse-induced bone loss in mice. We also found that obesity enhances the recovery of bone and muscle masses as well as strength decreased by disuse after reloading in mice. Leptin may be involved in the recovery of muscle and bone enhanced by obesity in mice.
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢社会を迎えた我が国において、健康寿命を著しく損なう骨粗鬆症や筋量と筋機能の両方が低下するサルコペニアへの対応が臨床的に喫緊の問題となっており、高齢者医療の現状と医療経済的な面を鑑みると、サルコペニアと骨粗鬆症の両者に有効な薬剤の開発が必要である。骨粗鬆症とサルコペニアの病因には共通したメカニズムの存在が推定されているが、これには筋と骨のネットワーク機構の関与が示唆されている。本研究より得られた成果は、骨粗鬆症とサルコペニアに共通した新しい病態機序の解明の手掛かりとなり、将来的には骨粗鬆症とサルコペニアの診断に有用な血中マーカーや治療標的の確立に繋がることが期待される。
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Report
(4 results)
Research Products
(21 results)
