Regulation of cytoskeleton and energy metabolism in adipocytes by adrenomedullin-RAMP2 system
| Project/Area Number |
16K08545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アドレノメデュリン / 脂肪細胞 |
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| Outline of Final Research Achievements |
Adrenomedullin (AM) is a vasodilatory peptide, which possess various bioactivities. AM and receptor activity-modifying protein 2 (RAMP2) are highly expressed in adipose tissues. In this study, to clarify the regulation of cytoskeleton and energy metabolism in adipocytes by AM-RAMP2 system, we analyzed adipocyte-specific RAMP2 knockout mice. We showed that AM-RAMP2 system regulates cytoskeleton of inguinal white adipose tissue and brown adipose tissue, and participates in adipocyte differentiation and energy metabolism.
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| Academic Significance and Societal Importance of the Research Achievements |
AMはペプチドで血中半減期が短いため、それ自体を慢性疾患の治療薬として利用することは難しい。そこで、AMの受容体側に着目し、その受容体活性調節タンパクであるRAMP2を標的とした治療法の開発を検討している。RAMP2は1回膜貫通型タンパクであり、比較的単純な構造のため治療標的分子となる可能性が高いと考えられ、本研究の成果により、RAMP2を標的としたメタボリックシンドロームの治療法開発に展開することが期待される。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.2017
Author(s)
Imai A, Toriyama Y, Iesato Y, Hirabayasi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T
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Journal Title
Am J Phthol.
Volume: 187(5)
Pages: 999-1015
DOI
Related Report
Peer Reviewed
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[Presentation] Regulation of Cytoskeleton and Energy Metabolism of Adipocytes by Adrenomedullin-RAMP2 System2018
Author(s)
Akiko Kamiyoshi, Takayuki Sakurai, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Liuyu Zhai, Kazutaka Hirabayashi, Kun Dai, Nanqi Cui, Yangxuan Wei, Masaaki Tanaka, Keiya Tanimura, Teng Liu, Haruka Tomiyama, Shuhei Matsui, Akihiro Yamauchi, Takayuki Shindo.
Organizer
第82回日本循環器学会
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