| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study was to clarify whether intranasal administration of an inhibitor (antimiR) to microRNA-96-5p, which suppresses neuronal glutathione (GSH) production, can increase GSH levels against neurodegeneration due to oxidative stress in the mouse brain. Although the neuroprotective effect is still inconclusive under oxidative stress, a high-dose intranasal administration of antimiR to microRNA-96-5p confirmed the central migration and increased neuronal GSH levels in the hippocampus. Additional drug delivery strategy to the intranasal administration would be needed for both enhancing the efficacy and reducing the dose of antimiR in vivo.
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