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Roles of microRNA in age-related disruption of tissue homeostasis

Research Project

Project/Area Number 16K08602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionShiga University of Medical Science

Principal Investigator

Kaneda Hayato  滋賀医科大学, 医学部, 准教授 (40528212)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords幹細胞老化 / microRNA / 組織幹細胞 / 間葉系幹細胞 / 腸管上皮幹細胞 / 老化 / 再生 / 幹細胞 / 再生医学
Outline of Final Research Achievements

Functional recovery of tissue stem cells by a specific growth factor has opened the possibility for the therapy of geriatric diseases. However, molecular mechanisms underlying the disruption of organismal homeostasis remains largely unknown. Previously, we have demonstrated that some of microRNAs are important for the regulation of stem cell functions. These results provided insight into its relationship to the stem cell aging. In this study, we first investigated molecular mechanisms underlying the stem cell aging. Based on the results of it, we next generated gene-modified mice that can induce the tissue-specific stem cell aging. We confirmed aging-like molecular dynamics in the specific tissues; therefore, our mouse might be a useful for aging studies.

Academic Significance and Societal Importance of the Research Achievements

世界的な高齢化の進行により老化研究が推進されつつあるが、未だ老化自体の分子メカニズムはほとんど明らかになっていない。幹細胞老化を調べることで、細胞老化と個体老化との関連を分子レベルで理解できる可能性がある。本研究では様々な幹細胞老化に共通する分子機構を調べ、それに基づいて幹細胞老化を模倣する遺伝子改変マウスを作製した。老化メカニズムの一端を解明しただけでなく、このマウス自体が次の老化研究に有用なツールとなり得る。がんを含む老年性疾患の克服と健康寿命の延伸に向けた重要な一歩となる成果だと考えられる。

Report

(2 results)
  • 2018 Final Research Report ( PDF )
  • 2016 Research-status Report

Research Products

(3 results)

All 2017 2016

All Journal Article Presentation

  • [Journal Article] Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.2016

    • Author(s)
      Hisamatsu D, Ohno-Oishi M, Nakamura S, Mabuchi Y, Naka-Kaneda H
    • Journal Title

      Aging

      Volume: 8(6) Pages: 1259-1275

    • DOI

      10.18632/aging.100982

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells.2016

    • Author(s)
      Hisamatsu D. & Naka-Kaneda H.
    • Journal Title

      Neural Regen Res

      Volume: 11 Pages: 1746-1747

    • DOI

      10.4103/1673-5374.194715

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 間葉系幹細胞由来因子Gdf6による老年性機能障害の回復2017

    • Author(s)
      金田勇人
    • Organizer
      日本解剖学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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