Screening of drug target proteins for diabetic nephropathy by identification of ChREBP complex from renal mesangial cells
| Project/Area Number |
16K08606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
SHIMA hiroki
SUGAWARA akira
NORO erika
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生化学 / 糖尿病 / 腎症 / 糖尿病性腎症 / ChREBP / メサンギウム細胞 / 炎症 / RIME / 代謝異常学 / 遺伝子発現制御 |
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| Outline of Final Research Achievements |
In this research projecct, we focused on ChREBP, a DNA-binding transcription factor which is believed to be involved in diabetic nephropathy pathogenesis. To understand ChREBP-mediated transcriptional regulation, we tried to identify ChREBP-containing protein complex using renal mesangial cells. In this attempt, we identified several coregulator candidates for ChREBP and, we also identified cross-talk mechanisms between ChREBP and inflammation signals. To developing drugs targeting these factors might be promising strategy for diabetic nephropathy and other metabolic syndromes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題においては、糖尿病性腎症の発症に関わると考えられているChREBPという転写因子に着目しその転写活性を制御するメカニズムの解明を行った。その結果、転写制御に関わると考えられる候補因子を複数見出すことができた。これらの因子の解析と、これらを標的とした薬剤の開発は糖尿病性腎症をはじめとした生活習慣病の治療薬の開発へと繋がる可能性がある。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Endogenous purification of NR4A2 (Nurr1) identified Poly(ADP-ribose) polymerase 1 as a prime coregulator in human adrenocortical H295R cells.2018
Author(s)
Noro, E., Yokoyama, A., Kobayashi, M., Shimada, H., Suzuki, S., Hosokawa, M., Takehara, T., Parvin, R., Shima, H., Igarashi, K. and Sugawara A.
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Journal Title
Int J Mol Sci
Volume: 19
Pages: 1406-1406
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion.2018
Author(s)
Satoshi Aoki, Akiko Saito-Hakoda, Takeo Yoshikawa, Kyoko Shimizu, Kiyomi Kisu, Susumu Suzuki, Kiyoshi Takagi, Shuji Mizumoto, Shuhei Yamada, Toin H. van Kuppevelt, Atsushi Yokoyama, Taiji Matsusaka, Hiroshi Sato, Sadayoshi Ito, and Akira Sugawara
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Journal Title
Nephrol. Dial. Transplant.
Volume: 33
Pages: 26-33
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Involvement of IKK Complex in the Regulation of a Glucose-Responsive Transcriptional Factor ChREBP in Pancreatic β-cell2018
Author(s)
Erika Noro, Atsushi Yokoyama, Naotaka Kogure, Rina Momma, Kyoko Shimizu, Rehana Parvin, Susumu Suzuki, Hiroki Shimada, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara
Organizer
ENDO 2018
Related Report
Int'l Joint Research
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