| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
It has been reported that macrophages express androgen receptors. Therefore, we focused on the relationship between cancer-associated macrophages and intratumoral androgen in breast cancer tissues. Immunohistochemistry demonstrated that androgen receptors were expressed in breast cancer-associated macrophages. Macrophage infiltration was correlated with shorter disease-free and breast cancer-specific survival, especially in the cases positive for androgen-producing enzymes. When we treated THP-1-delived macrophages with R1881, synthetic androgens, expression of CC motif chemokine 5 (CCL5) was significantly increased. Furthermore, recombinant CCL5 significantly promoted invasion of MCF-7 breast cancer cell line.
We therefore concluded that breast cancer-associated macrophages expressed androgen receptor and androgen-induced CCL5 by macrophages caused invasion, angiogenesis and distant metastasis of breast cancer patients.
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