Pathological and genomic analyses of gastric-type adenocarcinoma of the uterine cervix

• Project/Area Number: 16K08646
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Osaka University (2018); Akita University (2016-2017)
• Principal Investigator: Maeda Daichi 大阪大学, 医学系研究科, 特任教授(常勤) (30585500)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 子宮頸部腺癌 / 子宮頚部腺癌 / 病理解剖

Outline of Final Research Achievements

Comprehensive pathological analyses on gastric-type adenocarcinoma of the uterine cervix and lobular endocervical glandular hyperplasia was performed. Expression of various genes were evaluated in these lesions, and Claudin-18 was identified as a marker for gastric-type adenocarcinoma and lobular endocervical glandular hyperplasia.

Academic Significance and Societal Importance of the Research Achievements

一般的に病理診断が難しいとされる子宮頸部腺系病変の領域において、Claudin-18は胃型病変と非胃型病変を鑑別する鋭敏なマーカーとなることが明らかになった。診断マーカーとしての意義に加えて、予後との相関を示せたことで、臨床的にも意義深いと考えられる。

Research Products

• [Journal Article] Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment (2019)
  • Author(s): Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M.
  • Journal Title: Oncogene Volume: 38(12): Pages: 2162-2176
  • DOI: 10.1038/s41388-018-0564-x
  • Peer Reviewed
• [Journal Article] Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review. (2019)
  • Author(s): Akiyama Y, Homma Y, Maeda D.
  • Journal Title: Histol Histopathol. Volume: 34 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression (2018)
  • Author(s): Tamura Daisuke、Maeda Daichi、Halimi Sultan Ahmad、Okimura Masato、Kudo-Asabe Yukitsugu、Ito Satoru、Sato Naoki、Shibahara Junji、Nanjo Hiroshi、Terada Yukihiro、Goto Akiteru
  • Journal Title: Histopathology Volume: 73 Pages: 1013-1022
  • DOI: 10.1111/his.13726
  • Peer Reviewed / Open Access
• [Journal Article] MED12 is frequently mutated in ovarian and other adnexal leiomyomas (2018)
  • Author(s): Li Zhuo、Maeda Daichi、Kudo-Asabe Yukitsugu、Tamura Daisuke、Nanjo Hiroshi、Hayashi Akimasa、Ikemura Masako、Fukayama Masashi、Goto Akiteru
  • Journal Title: Human Pathology Volume: 81 Pages: 89-95
  • DOI: 10.1016/j.humpath.2018.06.013
  • Peer Reviewed / Open Access
• [Journal Article] Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation. (2018)
  • Author(s): Ito Y, Yoshida M, Maeda D, Takahashi M, Nanjo H, Masuda H, Goto A.
  • Journal Title: Sci Rep. Volume: 8 Pages: 3156-3156
  • DOI: 10.1038/s41598-018-21535-2
  • NAID: 120007089051
  • Peer Reviewed / Open Access
• [Journal Article] Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer. (2018)
  • Author(s): Saito M, Saito K, Shiraishi K, Maeda D, Suzuki H, Minamiya Y, Kono K, Kohno T, Goto A.
  • Journal Title: Mol Clin Oncol Volume: 8 Pages: 310-314
  • DOI: 10.3892/mco.2017.1536
  • Peer Reviewed / Open Access
• [Journal Article] Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. (2018)
  • Author(s): Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y, Takenoshita S.
  • Journal Title: Oncology Letters Volume: 15 Pages: 2401-2406
  • DOI: 10.3892/ol.2017.7536
  • NAID: 120007089076
  • Peer Reviewed
• [Journal Article] Digital quantitative analysis of mast cell infiltration in interstitial cystitis. (2018)
  • Author(s): Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M, Homma Y.
  • Journal Title: Neurourology and Urodynamics Volume: 37 Pages: 650-657
  • DOI: 10.1002/nau.23365
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fetal gut-like differentiation in gallbladder cancer. (2017)
  • Author(s): Koyama K, Maeda D, Tamura D, Narita C, Kudo-Asabe Y, Sato T, Yamamoto Y, Sageshima M, Nanjo H, Goto A.
  • Journal Title: Hum Pathol. Volume: 70 Pages: 27-34
  • DOI: 10.1016/j.humpath.2017.09.009
  • Peer Reviewed
• [Journal Article] The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases. (2017)
  • Author(s): Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D.
  • Journal Title: PLoS One Volume: 12 Pages: 1-6
  • DOI: 10.1371/journal.pone.0181270
  • NAID: 120007089063
  • Peer Reviewed / Open Access
• [Journal Article] Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. (2017)
  • Author(s): Mouse Models. Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, Sun-Wada GH, Wada Y, Ohnishi H.
  • Journal Title: Scientific Reports Volume: 7 Pages: 2817-2817
  • DOI: 10.1038/s41598-017-02988-3
  • NAID: 120007089052
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing. (2017)
  • Author(s): Ito Y, Maeda D, Yoshida M, Yoshida A, Kudo-Asabe Y, Nanjyo H, Izumi C, Yamamoto F, Inoue M, Shibata H, Katoh H, Ishikawa S, Nakamura H, Totoki Y, Shibata T, Yachida S, Goto A.
  • Journal Title: Virchows Arch. Volume: 471 Pages: 423-428
  • DOI: 10.1007/s00428-017-2135-x
  • Peer Reviewed
• [Journal Article] Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer. (2017)
  • Author(s): Oki S, Sone K, Oda K, Hamamoto R, Ikemura M, Maeda D, Takeuchi M, Tanikawa M, Mori-Uchino M, Nagasaka K, Miyasaka A, Kashiyama T, Ikeda Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Fukayama M, Osuga Y, Fujii T.
  • Journal Title: Oncotarget. Volume: in press Pages: 40402-40411
  • DOI: 10.18632/oncotarget.16316
  • NAID: 120007089062
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients. (2017)
  • Author(s): Shintani-Domoto Y, Hayasaka T, Maeda D, Masaki N, Ito TK, Sakuma K, Tanaka M, Kabashima K, Takei S, Setou M, Fukayama M.
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics Volume: S1570-9639 Pages: 30048-1
  • DOI: 10.1016/j.bbapap.2017.03.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mesothelial cells create a novel tissue niche that facilitates gastric cancer invasion (2017)
  • Author(s): Tanaka M., Kuriyama S., Itoh G., Maeda D., Goto A., Tamiya Y., Yanagihara K., Yashiro M., Aiba N.
  • Journal Title: Cancer Res Volume: ７７ Pages: 684-695
  • DOI: 10.1158/0008-5472.can-16-0964
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PIK3CA and AKT1 mutations in hidradenoma papilliferum. (2017)
  • Author(s): Goto K, Maeda D, Kudo-Asabe Y, Hibiya T, Hayashi A, Fukayama M, Ohashi K, Goto A.
  • Journal Title: J Clin Pathol. Volume: May;70(5) Pages: 424-427
  • DOI: 10.1136/jclinpath-2016-204003
  • Peer Reviewed
• [Journal Article] Expression of Cell Competition Markers at the Interface between p53 Signature and Normal Epithelium in the Human Fallopian Tube (2016)
  • Author(s): Kito M, Maeda D, Kudo-Asabe Y, Sato N, Shih IeM, Wang TL, Tanaka M, Terada Y, Goto A
  • Journal Title: PLoS One. Volume: 11
  • DOI: 10.1371/journal.pone.0156069
  • NAID: 120007089065
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Tumor Heterogeneity can be Assessed by Exome Sequencing of Cell-free DNA in Post-mortem Blood Sample: The “Liquid Autopsy” (2018)
  • Author(s): Daichi Maeda, Erina Takai, Shinichi Yachida, Akiteru Goto.
  • Organizer: The 107th Annual Meeting of the USCAP
  • Int'l Joint Research
• [Presentation] p16 Upregulation in Uterine Adenomatoid Tumor (2018)
  • Author(s): Daisuke Tamura, Daichi Maeda, Yukihiro Terada, Akiteru Goto.
  • Organizer: The 107th Annual Meeting of the USCAP
  • Int'l Joint Research
• [Presentation] Frequent Presence of β-Catenin Signature in the Tubal Epithelium (2018)
  • Author(s): Kei Koyama, Daichi Maeda, Akiteru Goto.
  • Organizer: The 107th Annual Meeting of the USCAP
  • Int'l Joint Research