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Pathological and genomic analyses of gastric-type adenocarcinoma of the uterine cervix

Research Project

Project/Area Number 16K08646
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOsaka University (2018)
Akita University (2016-2017)

Principal Investigator

Maeda Daichi  大阪大学, 医学系研究科, 特任教授(常勤) (30585500)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords子宮頸部腺癌 / 子宮頚部腺癌 / 病理解剖
Outline of Final Research Achievements

Comprehensive pathological analyses on gastric-type adenocarcinoma of the uterine cervix and lobular endocervical glandular hyperplasia was performed. Expression of various genes were evaluated in these lesions, and Claudin-18 was identified as a marker for gastric-type adenocarcinoma and lobular endocervical glandular hyperplasia.

Academic Significance and Societal Importance of the Research Achievements

一般的に病理診断が難しいとされる子宮頸部腺系病変の領域において、Claudin-18は胃型病変と非胃型病変を鑑別する鋭敏なマーカーとなることが明らかになった。診断マーカーとしての意義に加えて、予後との相関を示せたことで、臨床的にも意義深いと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2019 2018 2017 2016

All Journal Article (17 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 11 results,  Acknowledgement Compliant: 3 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment2019

    • Author(s)
      Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M.
    • Journal Title

      Oncogene

      Volume: 38(12): Issue: 12 Pages: 2162-2176

    • DOI

      10.1038/s41388-018-0564-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review.2019

    • Author(s)
      Akiyama Y, Homma Y, Maeda D.
    • Journal Title

      Histol Histopathol.

      Volume: 34 Pages: 25-32

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression2018

    • Author(s)
      Tamura Daisuke、Maeda Daichi、Halimi Sultan Ahmad、Okimura Masato、Kudo-Asabe Yukitsugu、Ito Satoru、Sato Naoki、Shibahara Junji、Nanjo Hiroshi、Terada Yukihiro、Goto Akiteru
    • Journal Title

      Histopathology

      Volume: 73 Issue: 6 Pages: 1013-1022

    • DOI

      10.1111/his.13726

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MED12 is frequently mutated in ovarian and other adnexal leiomyomas2018

    • Author(s)
      Li Zhuo、Maeda Daichi、Kudo-Asabe Yukitsugu、Tamura Daisuke、Nanjo Hiroshi、Hayashi Akimasa、Ikemura Masako、Fukayama Masashi、Goto Akiteru
    • Journal Title

      Human Pathology

      Volume: 81 Pages: 89-95

    • DOI

      10.1016/j.humpath.2018.06.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation.2018

    • Author(s)
      Ito Y, Yoshida M, Maeda D, Takahashi M, Nanjo H, Masuda H, Goto A.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 3156-3156

    • DOI

      10.1038/s41598-018-21535-2

    • NAID

      120007089051

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer.2018

    • Author(s)
      Saito M, Saito K, Shiraishi K, Maeda D, Suzuki H, Minamiya Y, Kono K, Kohno T, Goto A.
    • Journal Title

      Mol Clin Oncol.

      Volume: 8 Pages: 310-314

    • DOI

      10.3892/mco.2017.1536

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer.2018

    • Author(s)
      Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y, Takenoshita S.
    • Journal Title

      Oncol Lett.

      Volume: 15 Pages: 2401-2406

    • DOI

      10.3892/ol.2017.7536

    • NAID

      120007089076

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Digital quantitative analysis of mast cell infiltration in interstitial cystitis.2018

    • Author(s)
      Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M, Homma Y.
    • Journal Title

      Neurourol Urodyn.

      Volume: 37 Issue: 2 Pages: 650-657

    • DOI

      10.1002/nau.23365

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fetal gut-like differentiation in gallbladder cancer.2017

    • Author(s)
      Koyama K, Maeda D, Tamura D, Narita C, Kudo-Asabe Y, Sato T, Yamamoto Y, Sageshima M, Nanjo H, Goto A.
    • Journal Title

      Hum Pathol.

      Volume: 70 Pages: 27-34

    • DOI

      10.1016/j.humpath.2017.09.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.2017

    • Author(s)
      Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D.
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 7 Pages: 1-6

    • DOI

      10.1371/journal.pone.0181270

    • NAID

      120007089063

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.2017

    • Author(s)
      Mouse Models. Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, Sun-Wada GH, Wada Y, Ohnishi H.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 2817-2817

    • DOI

      10.1038/s41598-017-02988-3

    • NAID

      120007089052

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing.2017

    • Author(s)
      Ito Y, Maeda D, Yoshida M, Yoshida A, Kudo-Asabe Y, Nanjyo H, Izumi C, Yamamoto F, Inoue M, Shibata H, Katoh H, Ishikawa S, Nakamura H, Totoki Y, Shibata T, Yachida S, Goto A.
    • Journal Title

      Virchows Arch.

      Volume: 471 Issue: 3 Pages: 423-428

    • DOI

      10.1007/s00428-017-2135-x

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer2017

    • Author(s)
      Oki S, Sone K, Oda K, Hamamoto R, Ikemura M, Maeda D, Takeuchi M, Tanikawa M, Mori-Uchino M, Nagasaka K, Miyasaka A, Kashiyama T, Ikeda Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Fukayama M, Osuga Y, Fujii T.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 25 Pages: 40402

    • DOI

      10.18632/oncotarget.16316

    • NAID

      120007089062

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients.2017

    • Author(s)
      Shintani-Domoto Y, Hayasaka T, Maeda D, Masaki N, Ito TK, Sakuma K, Tanaka M, Kabashima K, Takei S, Setou M, Fukayama M.
    • Journal Title

      Biochim Biophys Acta

      Volume: S1570-9639 Issue: 7 Pages: 30048-1

    • DOI

      10.1016/j.bbapap.2017.03.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mesothelial cells create a novel tissue niche that facilitates gastric cancer invasion2017

    • Author(s)
      Tanaka M., Kuriyama S., Itoh G., Maeda D., Goto A., Tamiya Y., Yanagihara K., Yashiro M., Aiba N.
    • Journal Title

      Cancer Research

      Volume: 77 Issue: 3 Pages: 684-695

    • DOI

      10.1158/0008-5472.can-16-0964

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PIK3CA and AKT1 mutations in hidradenoma papilliferum.2017

    • Author(s)
      Goto K, Maeda D, Kudo-Asabe Y, Hibiya T, Hayashi A, Fukayama M, Ohashi K, Goto A.
    • Journal Title

      J Clin Pathol.

      Volume: May;70(5) Issue: 5 Pages: 424-427

    • DOI

      10.1136/jclinpath-2016-204003

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of Cell Competition Markers at the Interface between p53 Signature and Normal Epithelium in the Human Fallopian Tube2016

    • Author(s)
      Kito M, Maeda D, Kudo-Asabe Y, Sato N, Shih IeM, Wang TL, Tanaka M, Terada Y, Goto A
    • Journal Title

      PLoS One

      Volume: 11 Issue: 6 Pages: e0156069-e0156069

    • DOI

      10.1371/journal.pone.0156069

    • NAID

      120007089065

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Tumor Heterogeneity can be Assessed by Exome Sequencing of Cell-free DNA in Post-mortem Blood Sample: The “Liquid Autopsy”2018

    • Author(s)
      Daichi Maeda, Erina Takai, Shinichi Yachida, Akiteru Goto.
    • Organizer
      The 107th Annual Meeting of the USCAP
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] p16 Upregulation in Uterine Adenomatoid Tumor2018

    • Author(s)
      Daisuke Tamura, Daichi Maeda, Yukihiro Terada, Akiteru Goto.
    • Organizer
      The 107th Annual Meeting of the USCAP
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Frequent Presence of β-Catenin Signature in the Tubal Epithelium2018

    • Author(s)
      Kei Koyama, Daichi Maeda, Akiteru Goto.
    • Organizer
      The 107th Annual Meeting of the USCAP
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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