Role of intrinsic coagulation factors on atherothrombosis
| Project/Area Number |
16K08670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
盛口 清香 宮崎大学, 医学部, 助教 (90468041)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 動脈硬化性血栓 / 血液凝固FXI因子 / 組織因子 / キヌレニン代謝酵素 / 血液凝固XI因子 / 動脈硬化症 / 血栓症 / 内因系凝固因子 / 動脈血栓症 / 動脈硬化性血栓症 |
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| Outline of Final Research Achievements |
We investigated the role of intrinsic coagulation factors and extrinsic coagulation factor (TF: tissue factor) on atherothrombus formation. We found small amounts of collagenous matrix and neutrophil extracellular trap, activator of intrinsic factors, on ruptured coronary plaques. TF but not coagulation factor XI contributed mural thrombus formation in a rabbit model of plaque erosion. We found over expression of a tryptophan metabolic enzyme in thrombotic coronary plaques and its contribution of TF expression on activated macrophages. It is necessary to examine the role of intrinsic coagulation factors on thrombus growth on disrupted plaques.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、動脈硬化性プラークにおける内因系凝固因子（FXI)、外因系因子(組織因子)の機能を検討し、動脈硬化性血栓の形成メカニズムの解明を目的としました。冠動脈の血栓性プラークには内因系因子の活性化因子が少なく、組織因子が過剰に発現していました。その組織因子発現にトリプトファンのキヌレニン代謝酵素が作用していることを明らかにしました。動物モデルの検討で、組織因子は血栓形成の早期に作用していましたが、血液凝固FXI因子はその作用は明確ではありませんでした。今後、血栓の成長過程におけるFXIの作用を検討する必要があります。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits.2017
Author(s)
Matsuura Y, Yamashita A, Zhao Y, Iwakiri T, Yamasaki K, Sugita C, Koshimoto C, Kitamura K, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Morphological features of coronary plaques in WHHLMI rabbits (<i>Oryctolagus cuniculus</i>), an animal model for familial hypercholesterolemia2017
Author(s)
Yamada S, Koike T, Nakagawa T, Kuniyoshi, N Ying Y, Itabe H, Yamashita A, Asada Y, Shiomi M.
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Journal Title
Exp. Anim.
Volume: 印刷中
Issue: 2
Pages: 145-157
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed / Open Access
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