| Project/Area Number |
16K08671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
Woo Tetsukan 横浜市立大学, 医学部, 講師 (90537177)
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| Co-Investigator(Kenkyū-buntansha) |
奥寺 康司 横浜市立大学, 医学部, 准教授 (10326027)
荒井 宏雅 横浜市立大学, 医学研究科, 客員講師 (10381493)
益田 宗孝 横浜市立大学, 医学研究科, 教授 (10190365)
大橋 健一 横浜市立大学, 医学研究科, 教授 (40231203)
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| Project Period (FY) |
2016-10-21 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肺癌 / オリゴメタスターシス / 少数個転移 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the pathological characteristics of lung cancers that showed small number of metastases (oligometastasis). As a result of comparing the pathological factors between the oligometastasis and the polymetastasis group, the frequency of the mediastinal lymph node metastasis (N2) cases was significantly high in the polymetastasis group. A comprehensive analysis of tumor microRNA expression was performed using a gene chip microarray, and 20 microRNAs showing differential expression between the oligometastasis and the polymetastasis group were selected. As a result of verifying these expressions by Real-Time PCR, four microRNAs of miR-31-5p, miR-376c-3p, miR-127-3p and miR-150-5p are highly expressed in the oligometastasis group, and it was suggested that the relationship between microRNA expression and oligometastatic lung cancer was shown.
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| Academic Significance and Societal Importance of the Research Achievements |
現在まで、少数個転移（オリゴメタスターシス）肺癌の臨床的特徴を示した報告は複数認めるものの、病理学的特性を示した報告はほとんど認めなかった。本研究で示した腫瘍microRNA発現と少数個転移肺癌との関連性は、今後、多数個転移肺癌との峻別指標の確立に繋がる可能性がある。
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