Comparison of intravascular imaging and histopathology
| Project/Area Number |
16K08676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nihon University |
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Principal Investigator |
HAO Hiroyuki 日本大学, 医学部, 教授 (40393243)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 冠動脈硬化 / 血管内イメ－ジング / 病理解剖 / 心臓突然死 / 血管内イメージング / 病理学 / 冠状動脈 / 動脈硬化 |
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| Outline of Final Research Achievements |
The present study compared between the ex-vivo intravascular imaging and histopathology of coronary artery plaques using autopsy cases. The diagnostic accuracy of intravascular imaging for coronary artery plaque has been verified. Among the forensic autopsy cases, ex-vivo coronary artery imaging is useful to detect the coronary artery thrombosis. Furthermore, we examined the effect of the drug-coated balloon on restenosis after intervention in the peripheral artery of atherosclerotic animal model. We have demonstrated that the intravascular imaging can detect the delivered drug by drug-coated balloon.
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| Academic Significance and Societal Importance of the Research Achievements |
心臓突然死が疑われる法医解剖症例において、血管内イメージングを用いたオートプシーイメージングによる画像診断によって、詳細な冠動脈病変の検索が可能であった。ex-vivoにおける血管内イメ－ジングの解剖症例への応用は、病理解剖や法医解剖における診断精度の向上に役立つと考えられた。動物実験では薬剤コ－テッドバル－ンの血管内治療後の再狭窄病変に対する治療効果が動脈硬化発症モデル動物で証明された。さらに血管内イメージングで薬剤の血管壁に対する投与状態が検出可能であることを証明した。これら新規治療法の治療効果や画像所見の確証により、有効かつ安全にヒトへの治療が可能であることを確認できた。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Atherosclerotic Component of the Yellow Segment After Drug-Eluting Stent Implantation on Coronary Angioscopy - An Ex-Vivo Validation Study.2018
Author(s)
Shibuya M, Fujii K, Hao H, Imanaka T, Saita T, Kawakami R, Miki K, Tamaru H, Horimatsu T, Sumiyoshi A, Nishimura M, Hirota S, Masuyama T, Ishihara M.
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Journal Title
Circulation Journal
Volume: 83
Pages: 193-197
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histopathologic Insights Into the Honeycomb-Like Structure in the Coronary Artery: In Vivo Multimodality Imaging Assessment With Directional Coronary Atherectomy.2018
Author(s)
Suzuki S, Sotomi Y, Nakatani S, Hirata A, Hao H, Tsujimoto M, Tsuji H, Shiojima I, Sakata Y, Hirayama A, Higuchi Y
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Journal Title
JACC Cardiovasc Interv.
Volume: 11
Pages: 157-159
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histopathological validation of optical frequency domain imaging to quantify various types of coronary calcifications.2017
Author(s)
Saita T, Fujii K, Hao H, Imanaka T, Shibuya M, Fukunaga M, Miki K, Tamaru H, Horimatsu T, Nishimura M, Sumiyoshi A, Kawakami R, Naito Y, Kajimoto N, Hirota S, Masuyama T.
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Journal Title
Eur Heart J Cardiovasc Imaging.
Volume: 18
Pages: 342-349
Related Report
Peer Reviewed / Open Access
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