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Comparison of intravascular imaging and histopathology

Research Project

Project/Area Number 16K08676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionNihon University

Principal Investigator

HAO Hiroyuki  日本大学, 医学部, 教授 (40393243)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords冠動脈硬化 / 血管内イメ-ジング / 病理解剖 / 心臓突然死 / 血管内イメージング / 病理学 / 冠状動脈 / 動脈硬化
Outline of Final Research Achievements

The present study compared between the ex-vivo intravascular imaging and histopathology of coronary artery plaques using autopsy cases. The diagnostic accuracy of intravascular imaging for coronary artery plaque has been verified. Among the forensic autopsy cases, ex-vivo coronary artery imaging is useful to detect the coronary artery thrombosis. Furthermore, we examined the effect of the drug-coated balloon on restenosis after intervention in the peripheral artery of atherosclerotic animal model. We have demonstrated that the intravascular imaging can detect the delivered drug by drug-coated balloon.

Academic Significance and Societal Importance of the Research Achievements

心臓突然死が疑われる法医解剖症例において、血管内イメージングを用いたオートプシーイメージングによる画像診断によって、詳細な冠動脈病変の検索が可能であった。ex-vivoにおける血管内イメ-ジングの解剖症例への応用は、病理解剖や法医解剖における診断精度の向上に役立つと考えられた。動物実験では薬剤コ-テッドバル-ンの血管内治療後の再狭窄病変に対する治療効果が動脈硬化発症モデル動物で証明された。さらに血管内イメージングで薬剤の血管壁に対する投与状態が検出可能であることを証明した。これら新規治療法の治療効果や画像所見の確証により、有効かつ安全にヒトへの治療が可能であることを確認できた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (8 results)

  • [Journal Article] Atherosclerotic Component of the Yellow Segment After Drug-Eluting Stent Implantation on Coronary Angioscopy - An Ex-Vivo Validation Study.2018

    • Author(s)
      Shibuya M, Fujii K, Hao H, Imanaka T, Saita T, Kawakami R, Miki K, Tamaru H, Horimatsu T, Sumiyoshi A, Nishimura M, Hirota S, Masuyama T, Ishihara M.
    • Journal Title

      Circulation Journal

      Volume: 83 Pages: 193-197

    • NAID

      130007550424

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histopathologic Insights Into the Honeycomb-Like Structure in the Coronary Artery: In Vivo Multimodality Imaging Assessment With Directional Coronary Atherectomy.2018

    • Author(s)
      Suzuki S, Sotomi Y, Nakatani S, Hirata A, Hao H, Tsujimoto M, Tsuji H, Shiojima I, Sakata Y, Hirayama A, Higuchi Y
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 11 Pages: 157-159

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protruding In-Stent Mass After Bioresorbable Polymer Sirolimus-Eluting Stent - Ex Vivo Intravascular Imaging and Histopathology.2018

    • Author(s)
      Kawakami R, Imanaka T, Ishihara M, Kihara T, Fujii K, Hirota S, Hao H.
    • Journal Title

      Circulation Journal

      Volume: 82 Pages: 932-933

    • NAID

      130006394557

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atherosclerotic Plaque Component as a Risk Factor for Distal Embolization During Percutaneous Coronary Intervention - Pathology of Tissue Obtained by Distal Protection Device.2018

    • Author(s)
      Fujino A, Hao H, Shimodai S, Kawakami R, Matsuo K, Yasumura Y, Higuchi Y, Tsujimoto M, Ueda Y, Hirota S.
    • Journal Title

      Circulation Journal

      Volume: 82 Pages: 2292-2298

    • NAID

      130007438933

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Initial pathological responses of second-generation everolimus-eluting stents implantation in Japanese coronary arteries: Comparison with first-generation sirolimus-eluting stents.2018

    • Author(s)
      Kawakami R, Hao H, Imanaka T, Shibuya M, Ueda Y, Tsujimoto M, Ishibashi-Ueda H, Hirota S.
    • Journal Title

      Int J Cardiovasc Imaging.

      Volume: 71 Pages: 452-457

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neoatherosclerosis after paclitaxel-eluting stent implantation: Ex vivo intravascular image and histopathology.2017

    • Author(s)
      Kawakami Rika、Hao H
    • Journal Title

      Pathology International

      Volume: 67 Pages: 53-55

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protruding In-Stent Mass After Bioresorbable Polymer Sirolimus-Eluting Stent - Ex Vivo Intravascular Imaging and Histopathology.2017

    • Author(s)
      Kawakami R, Imanaka T, Ishihara M, Kihara T, Fujii K, Hirota S, Hao H.
    • Journal Title

      Circ J.

      Volume: 82 Pages: 932-933

    • NAID

      130006394557

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of plaque progression and promotion of plaque stability by glucagon-like peptide-1 receptor agonist: Serial in vivo findings from iMap-IVUS in Watanabe heritable hyperlipidemic rabbits.2017

    • Author(s)
      Sudo M, Li Y, Hiro T, Takayama T, Mitsumata M, Shiomi M, Sugitani M, Matsumoto T, Hao H, Hirayama A.
    • Journal Title

      Atherosclerosis.

      Volume: 265 Pages: 283-291

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An autopsy case of sudden cardiac death due to in-scaffold restenosis and late-scaffold thrombosis after bioresorbable vascular scaffold implantation; back to past stent era?2017

    • Author(s)
      Asakura K, Hao H.
    • Journal Title

      Eur Heart J.

      Volume: 38 Pages: 2571-2571

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histopathological validation of optical frequency domain imaging to quantify various types of coronary calcifications.2017

    • Author(s)
      Saita T, Fujii K, Hao H, Imanaka T, Shibuya M, Fukunaga M, Miki K, Tamaru H, Horimatsu T, Nishimura M, Sumiyoshi A, Kawakami R, Naito Y, Kajimoto N, Hirota S, Masuyama T.
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: 18 Pages: 342-349

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 頸動脈プラ-クの病理2018

    • Author(s)
      羽尾裕之
    • Organizer
      第37回 日本脳神経超音波学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 経皮的冠動脈形成術末梢保護デバイスにて採取された組織の病理学的検討2018

    • Author(s)
      羽尾裕之
    • Organizer
      第107回 日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Polyvascular Diseaseの病理と栓子生成メカニズム2018

    • Author(s)
      羽尾裕之
    • Organizer
      第21回 日本栓子検出と治療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中性脂肪蓄積心筋血管症の疾患概念と病理2018

    • Author(s)
      羽尾裕之
    • Organizer
      第78回 日本病理学会関東支部学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 剖検症例の冠動脈の検索方法と病理組織像の解釈2018

    • Author(s)
      羽尾裕之
    • Organizer
      第81回 日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] リスク予測の観点から見たプラ-ク診断2017

    • Author(s)
      羽尾裕之
    • Organizer
      第4回 日本心血管脳卒中学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Vulnerable plaque: 最新の知見2017

    • Author(s)
      羽尾裕之
    • Organizer
      第26回 日本心血管インタ-ベンション治療学会(CVIT2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] 血管内イメ-ジングと病理組織像との対比2017

    • Author(s)
      羽尾裕之
    • Organizer
      第31回日本心臓血管内視鏡学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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