Integrative analysis to identify the unique microRNA-mRNA regulatory network in EGFR-mutated lung adenocarcinoma: toward precision medicine

• Project/Area Number: 16K08679
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: KENTARO INAMRUA 公益財団法人がん研究会, がん研究所 病理部, 主任研究員 (40442545)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: マイクロRNA / メッセンジャーRNA / ドライバー遺伝子 / マイクロアレイ / 網羅的遺伝子発現解析 / 統合解析 / 肺がん / 腺がん / 肺癌 / 腺癌 / 人体病理学

Outline of Final Research Achievements

In lung adenocarcinoma, various mutations that drive cancer progression have emerged as druggable molecular targets. Among them, EGFR mutation is the most prevalent genetic alterations. EGFR-mutated lung adenocarcinoma is characterized by a distinct oncogenic pathway with unique microRNA-mRNA interactions. We investigated both microRNA and mRNA expression profiles using microarrays in 155 cases of lung adenocarcinoma. An integrative analysis of microRNA and mRNA expression revealed a list of microRNA-mRNA interactions in EGFR-mutated tumors. A network structural analysis provided a comprehensive view of the complex microRNA-mRNA interactions, including interactions of miR-500a-3p, miR-502-3p, and miR-652-3p with MUC4. Overall, this observational study provides insight into the unique microRNA-mRNA regulatory network in EGFR-mutated tumors. Our findings, if validated, would inform future research examining the interplay between microRNAs and mRNAs in EGFR-mutated lung adenocarcinoma.

Academic Significance and Societal Importance of the Research Achievements

EGFR変異は日本人の肺がんにおいて最も頻度の高いドライバー遺伝子異常である。一方、マイクロRNAはメッセンジャーRNAとの相互作用を介して発がん・がん進展において重要な働きをすることが知られている。本研究では、網羅的統合発現解析により、EGFR変異肺がんに特徴的なマイクロRNA－メッセンジャーRNA相互作用をネットワーク化した。本研究で同定されたEGFR変異肺がんに特徴的なマイクロRNA・メッセンジャーRNA間の相互作用は、EGFR変異肺がんの発がん・がん進展のメカニズムを理解する上で有用であると考えられる。将来的にはマイクロRNAをターゲットとする診断治療戦略に応用されることが期待される。

Research Products

• [Journal Article] Unique MicroRNA and mRNA Interactions in EGFR-Mutated Lung Adenocarcinoma (2018)
  • Author(s): Subat Sophia、Inamura Kentaro、Ninomiya Hironori、Nagano Hiroko、Okumura Sakae、Ishikawa Yuichi
  • Journal Title: Journal of Clinical Medicine Volume: 7 Issue: 11 Pages: 419-419
  • DOI: 10.3390/jcm7110419
  • Peer Reviewed / Open Access
• [Journal Article] CSF1R-Expressing Tumor-Associated Macrophages, Smoking and Survival in Lung Adenocarcinoma: Analyses Using Quantitative Phosphor-Integrated Dot Staining (2018)
  • Author(s): Inamura Kentaro、Shigematsu Yasuyuki、Ninomiya Hironori、Nakashima Yasuhiro、Kobayashi Maki、Saito Haruyuki、Takahashi Katsuhiro、Futaya Etsuko、Okumura Sakae、Ishikawa Yuichi、Kanda Hiroaki
  • Journal Title: Cancers Volume: 10 Issue: 8 Pages: 252-252
  • DOI: 10.3390/cancers10080252
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression. (2018)
  • Author(s): Inamura K.
  • Journal Title: Int J Mol Sci. Volume: 19(4) Issue: 4 Pages: 1259-1259
  • DOI: 10.3390/ijms19041259
  • Peer Reviewed / Open Access
• [Journal Article] Update on Immunohistochemistry for the Diagnosis of Lung Cancer. (2018)
  • Author(s): Inamura K.
  • Journal Title: Cancers (Basel) Volume: 10(3) Issue: 3 Pages: 72-72
  • DOI: 10.3390/cancers10030072
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Effect of Lymphovascular Invasion on TNM Staging in Stage I Non-Small-cell Lung Cancer. (2018)
  • Author(s): Noma D, Inamura K, Matsuura Y, Hirata Y, Nakajima T, Yamazaki H, Hirai Y, Ichinose J, Nakao M, Ninomiya H, Mun M, Nakagawa K, Masuda M, Ishikawa Y, Okumura S.
  • Journal Title: Clin Lung Cancer Volume: 19(1) Issue: 1 Pages: e109-e122
  • DOI: 10.1016/j.cllc.2017.06.001
  • Peer Reviewed
• [Journal Article] Bladder Cancer: New Insights into Its Molecular Pathology. (2018)
  • Author(s): Inamura K.
  • Journal Title: Cancers (Basel) Volume: 10(4) Issue: 4 Pages: 100-100
  • DOI: 10.3390/cancers10040100
  • Peer Reviewed / Open Access
• [Journal Article] Prostatic cancers: understanding their molecular pathology and the 2016 WHO classification. (2018)
  • Author(s): Inamura K.
  • Journal Title: Oncotarget Volume: 9(18) Issue: 18 Pages: 14723-14737
  • DOI: 10.18632/oncotarget.24515
  • Peer Reviewed / Open Access
• [Journal Article] Colorectal Cancers: An Update on Their Molecular Pathology. (2018)
  • Author(s): Inamura K.
  • Journal Title: Cancers (Basel) Volume: 10(1) Issue: 1 Pages: 26-26
  • DOI: 10.3390/cancers10010026
  • Peer Reviewed / Open Access
• [Journal Article] Genetic mechanisms of immune evasion in colorectal cancer. (2018)
  • Author(s): Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, et al.
  • Journal Title: Cancer Discov. Volume: 印刷中 Issue: 6 Pages: 730-749
  • DOI: 10.1158/2159-8290.cd-17-1327
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Osteosarcoma arising in fibrous dysplasia, confirmed by mutational analysis of GNAS gene. (2018)
  • Author(s): Sugiura Y, Kanda H, Motoi N, Nomura K, Inamura K, Okada E, Matsumoto H, Shimoji T, Matsumoto S, Nakayama J, Takazawa Y, Ishikawa Y, Machinami R.
  • Journal Title: Pathol Res Pract. Volume: 214(2) Issue: 2 Pages: 318-324
  • DOI: 10.1016/j.prp.2017.10.018
  • Peer Reviewed
• [Journal Article] Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer. (2017)
  • Author(s): Inamura K.
  • Journal Title: Cancers (Basel) Volume: 9(5) Issue: 5 Pages: 49-49
  • DOI: 10.3390/cancers9050049
  • Peer Reviewed / Open Access
• [Journal Article] Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer. (2017)
  • Author(s): Inamura K.
  • Journal Title: Cells Volume: 6(2) Issue: 2 Pages: 12-12
  • DOI: 10.3390/cells6020012
  • Peer Reviewed / Open Access
• [Journal Article] Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification. (2017)
  • Author(s): Inamura K.
  • Journal Title: Front Oncol. Volume: 7 Pages: 193-193
  • DOI: 10.3389/fonc.2017.00193
  • Peer Reviewed / Open Access
• [Journal Article] Association of tumor TROP2 expression with prognosis varies among lung cancer subtypes. (2017)
  • Author(s): Inamura K, Yokouchi Y, Kobayashi M, Ninomiya H, Sakakibara R, Subat S, Nagano H, Nomura K, Okumura S, Shibutani T, Ishikawa Y.
  • Journal Title: Oncotarget Volume: 8(17) Pages: 28725-28735
  • Peer Reviewed / Open Access
• [Journal Article] Relationship of tumor PD-L1 (CD274) expression with lower mortality in lung high-grade neuroendocrine tumor (2017)
  • Author(s): Inamura Kentaro、Yokouchi Yusuke、Kobayashi Maki、Ninomiya Hironori、Sakakibara Rie、Nishio Makoto、Okumura Sakae、Ishikawa Yuichi
  • Journal Title: Cancer Medicine Volume: 6 Issue: 10 Pages: 2347-2356
  • DOI: 10.1002/cam4.1172
  • Peer Reviewed / Open Access
• [Journal Article] Tumor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis. (2017)
  • Author(s): Inamura K, Yokouchi Y, Kobayashi M, Sakakibara R, Ninomiya H, Subat S, Nagano H, Nomura K, Okumura S, Shibutani T, Ishikawa Y.
  • Journal Title: Lung Cancer Volume: 103 Pages: 44-51
  • DOI: 10.1016/j.lungcan.2016.11.013
  • Peer Reviewed
• [Journal Article] Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification. (2017)
  • Author(s): Inamura K.
  • Journal Title: Int J Mol Sci. Volume: 18(10) Issue: 10 Pages: 2195-2195
  • DOI: 10.3390/ijms18102195
  • Peer Reviewed / Open Access
• [Journal Article] Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features. (2017)
  • Author(s): Inamura K.
  • Journal Title: Cancers (Basel) Volume: 9(9) Issue: 9 Pages: 111-111
  • DOI: 10.3390/cancers9090111
  • Peer Reviewed / Open Access
• [Journal Article] A novel fusion of HNRNPA-ALK in inflammatory myofibroblastic tumor of urinary bladder (2017)
  • Author(s): Inamura K, Kobayashi M, Nagano H, Sugiura Y, Ogawa M, Masuda H, Yonese J, Ishikawa Y.
  • Journal Title: Human Pathology Volume: 印刷中 Pages: 96-100
  • DOI: 10.1016/j.humpath.2017.04.022
  • Peer Reviewed
• [Journal Article] Skene's gland adenocarcinoma with intestinal differentiation: A case report and literature review. (2017)
  • Author(s): Muto M, Inamura K, Ozawa N, Endo T, Masuda H, Yonese J, Ishikawa Y.
  • Journal Title: Pathol Int. Volume: 67(11) Issue: 11 Pages: 575-579
  • DOI: 10.1111/pin.12571
  • Peer Reviewed
• [Journal Article] Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer. (2017)
  • Author(s): Masugi Y, Nishihara R, Hamada T, Song M, da Silva A, Kosumi K, Gu M, Shi Y, Li W, Liu L, Nevo D, Inamura K, Cao Y, Liao X, Nosho K, Chan AT, Giannakis M, Bass AJ, Hodi FS, Freeman GJ, Rodig SJ, Fuchs CS, Qian ZR, Nowak JA, Ogino S.
  • Journal Title: Cancer Immunol Res. Volume: 5(11) Issue: 11 Pages: 1046-1055
  • DOI: 10.1158/2326-6066.cir-17-0122
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. (2017)
  • Author(s): Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S.
  • Journal Title: Gastroenterology. Volume: 153(6) Issue: 6 Pages: 1517-1530.e14
  • DOI: 10.1053/j.gastro.2017.08.045
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tumour CD274 (PD-L1) expression and T cells in colorectal cancer. (2017)
  • Author(s): Masugi Y, Nishihara R, Yang J, Mima K, da Silva A, Shi Y, Inamura K, Cao Y, Song M, Nowak JA, Liao X, Nosho K, Chan AT, Giannakis M, Bass AJ, Hodi FS, Freeman GJ, Rodig S, Fuchs CS, Qian ZR, Ogino S.
  • Journal Title: Gut Volume: 印刷中 Issue: 8 Pages: 1463-1473
  • DOI: 10.1136/gutjnl-2016-311421
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] EBUS-TBNA as a promising method for the evaluation of tumor PD-L1 expression in lung cancer. (2016)
  • Author(s): Sakakibara R, Inamura K, Tambo Y, et al.
  • Journal Title: Clinical Lung Cancer. Volume: 印刷中 Issue: 5 Pages: 527-534
  • DOI: 10.1016/j.cllc.2016.12.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors. (2016)
  • Author(s): Qian ZR, Li T, Ter-Minassian M, Yang J, Chan JA, Brais LK, Masugi Y, Thiaglingam A, Brooks N, Nishihara R, Bonnemarie M, Masuda A, Inamura K, Kim SA, Mima K, Sukawa Y, Dou R, Lin X, Christiani DC, Schmidlin F, Fuchs CS, Mahmood U, Ogino S, Kulke MH.
  • Journal Title: Pancreas Volume: 45 Issue: 10 Pages: 1386-1393
  • DOI: 10.1097/mpa.0000000000000700
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Thymic oncocytic carcinoid with a markedly elevated level of maximum SUV. (2016)
  • Author(s): Noma D, Inamura K, Mun M, Terauchi T, Matsuura Y, Nakao M, Ninomiya H, Nakagawa K, Masuda M, Okumura S, Ishikawa Y.
  • Journal Title: Pathol Int. Volume: 66 Issue: 10 Pages: 593-595
  • DOI: 10.1111/pin.12449
  • Peer Reviewed / Open Access
• [Journal Article] Relationship of tumor PD-L1 expression with EGFR wild type status and poor prognosis in lung adenocarcinoma (2016)
  • Author(s): Inamura K, Yokouchi Y, Sakakibara R, Kobayashi M, Subat S, Ninomiya H, Nagano H, Nomura K, Okumura S, Ishikawa Y.
  • Journal Title: Jpn J Clin Oncol Volume: 46 Issue: 10 Pages: 935-941
  • DOI: 10.1093/jjco/hyw087
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes. (2016)
  • Author(s): Cao Y, Nishihara R, Qian ZR, Song M, Mima K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Morikawa T, Zhang X, Wu K, Wang M, Garrett WS, Giovannucci EL, Fuchs CS, Chan AT, Ogino S.
  • Journal Title: Gastroenterology Volume: 151 Issue: 5 Pages: 879-892
  • DOI: 10.1053/j.gastro.2016.07.030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. (2016)
  • Author(s): Giannakis M, Mu XJ, Shukla SA, Qian ZR, Cohen O, Nishihara R, Bahl S, Cao Y, Amin-Mansour A, Yamauchi M, Sukawa Y, Stewart C, Rosenberg M, Mima K, Inamura K, Nosho K, Nowak JA, Lawrence MS, Giovannucci EL, Chan AT, Ng K, Meyerhardt JA, Van Allen EM, Getz G, Gabriel SB, Lander ES, Wu CJ, Fuchs CS, Ogino S, Garraway LA.
  • Journal Title: Cell Rep. Volume: １５ Issue: 4 Pages: 857-865
  • DOI: 10.1016/j.celrep.2016.03.075
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Marine ω-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells. (2016)
  • Author(s): Song M, Nishihara R, Cao Y, Chun E, Qian ZR, Mima K, Inamura K, Masugi Y, Nowak JA, Nosho K, Wu K, Wang M, Giovannucci E, Garrett WS, Fuchs CS, Ogino S, Chan AT.
  • Journal Title: JAMA Oncol. Volume: 2 Issue: 9 Pages: 1197-1206
  • DOI: 10.1001/jamaoncol.2016.0605
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate. (2016)
  • Author(s): Hanyuda A, Ogino S, Qian ZR, Nishihara R, Song M, Mima K, Inamura K, Masugi Y, Wu K, Meyerhardt JA, Chan AT, Fuchs CS, Giovannucci EL, Cao Y.
  • Journal Title: Int J Cancer Volume: 139 Issue: 4 Pages: 854-868
  • DOI: 10.1002/ijc.30122
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 肺癌の新WHO分類. (2016)
  • Author(s): 稲村健太郎, 石川雄一
  • Journal Title: 成人病と生活習慣病 Volume: 46 Pages: 419-426
• [Journal Article] 癌の分子病理学. 病理診断から治療標的探索まで: (第2部) 癌の分子病理学 臓器癌：肺癌. (2016)
  • Author(s): 稲村健太郎, 二宮浩範, 石川雄一
  • Journal Title: 病理と臨床 Volume: 34 (臨時増刊号) Pages: 146-154
• [Presentation] The microRNA-mRNA interactions in ALK-rearranged lung adenocarcinoma. (2019)
  • Author(s): Subat S, Inamura K, Ninomiya H, Nagano H, Okumura S, Ishikawa Y
  • Organizer: The AACR 110th Annual Meeting 2019, Atlanta, GA
  • Int'l Joint Research
• [Presentation] 肺癌のゲノムワイド解析 (2018)
  • Author(s): 稲村健太郎, 二宮浩範, ソフィア ソバティ, 石川雄一
  • Organizer: 第107回日本病理学会総会，札幌
• [Presentation] Sakakibara R, Ninomiya H, Inamura K, Nakashima Y, Okumura S, Ishikawa Y. Update in theDiagnosis of neuroendocrine tumor and its prognostic value. (2018)
  • Author(s): Sakakibara R, Ninomiya H, Inamura K, Nakashima Y, Okumura S, Ishikawa Y.
  • Organizer: The 5-th Asian-Australasian Pulmonary Pathology Society (AAPPS) annual conference
• [Presentation] 増殖能, 神経内分泌性の明瞭に異なる2成分から成る肺小細胞癌の1例 (2017)
  • Author(s): 二宮浩範, 中島康裕, 榊原里江, 武藤麻里子, 松田正典, 稲村健太郎, 石川雄一
  • Organizer: 第76回日本病理学会関東支部学術集会
• [Presentation] 肺神経内分泌腫瘍におけるInsulinoma-assosciated 1（INSM1）発現. (2017)
  • Author(s): 榊原里江, 小林真季, 高橋直子, 稲村健太郎, 二宮浩範, 西尾誠人, 奥村栄, 石川雄一.
  • Organizer: 第58回日本肺癌学会学術集会
• [Presentation] PD-L1 expression in high-grade neuroendocrine carcinoma of the lung. (2016)
  • Author(s): Inamura K.
  • Organizer: 11th Annual Meeting of the Asia-Pacific Societies for Molecular Immunology and 3rd Asia-Australasia Pulmonary Pathology Society Meeting.
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] Tumor B7-H3 (CD276) protein expression, smoking history, and survival in lung adenocarcinoma patients. (2016)
  • Author(s): Inamura K, Yokouchi Y, Kobayashi M, Sakakibara R, Ninomiya H, Subat S, Nagano H, Nomura K, Okumura S, Shibutani T, Ishikawa Y.
  • Organizer: 17th World conference on lung cancer
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Insulinoma-Associated 1 (INSM1) immunohistochemical expression in lung neuroendocrine tumors. (2016)
  • Author(s): Sakakibara R, Inamura K, Ninomiya H, Shigematsu Y, Kakita T, Noma D, Hirata Y, Matsuura Y, Nakao M, Mun M, Nishio M, Okumura S, Ishikawa Y.
  • Organizer: 17th World conference on lung cancer
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Skene’s gland adenocarcinoma with intestinal differentiation: a case report and literature review. (2016)
  • Author(s): Muto M, Inamura K, Uehara S, Endo T, Yonese J, Ishikawa Y.
  • Organizer: 第６回 日台合同スライドカンファレンス
  • Place of Presentation: 名古屋
  • Year and Date: 2016-10-14
  • Int'l Joint Research
• [Presentation] B7-H3 (CD276) expression, smoking history, and patient survival in lung adenocarcinoma. (2016)
  • Author(s): Inamura K, Kobayashi M, Sakakibara R, Ninomiya H, Subat S, Nagano H, Nomura K, Okumura S, Ishikawa Y.
  • Organizer: 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2016-10-06
• [Presentation] Asthma and risk of colorectal cancer according to tumor immunity and molecular subtypes. (2016)
  • Author(s): Li Y, Song M, Nishihara R, Qian ZR, Varraso R, Inamura K, Masugi Y, Giovannucci EL, Wang M, Camargo CA, Fuchs CS, Chan AT, Ogino S, Cao Y.
  • Organizer: AACR Special Conference: Colorectal Cancer: From Initiation to Outcomes
  • Place of Presentation: Tampa, FL, USA
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Aspirin Use and Risk of Colorectal Cancer According to Tumor Immunity Status. (2016)
  • Author(s): Cao Y, Nishihara R, Qian ZR, Song M, Mima K, Inamura K, Nowak J, Drew D, Lochhead P, Nosho K, Morikawa T, Zhang X, Wu K, Wang M, Garrett WS, Giovannucci E, Fuchs CS, Ogino S, Chan AT.
  • Organizer: Digestive Disease Week
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] B7-H3 protein expression and patient survival according to smoking status in lung adenocarcinoma (2016)
  • Author(s): 稲村健太郎, 横内友祐, 小林真季, 河内洋, 二宮浩範, ソバティ・ソフィア, 本田小吉, 小坂俊幸, 渋谷朋子, 石川雄一.,
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-05-12
• [Presentation] Marine ω-3 polyunsaturated fatty acid intake and risk of colorectal cancer according to tumor-infiltrating T cells. (2016)
  • Author(s): Song M, Nishihara R, Cao Y, Chun E, Qian ZR, Mima K, Inamura K, Masugi Y, Nowak J, Nosho K, Wu K, Wang M, Giovannucci E, Garrett WS, Fuchs CS, Ogino S, Chan AT.
  • Organizer: The AACR 107th Annual Meeting 2016
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Remarks] 公益財団法人がん研究会がん研究所病理部ホームページ
  • URL: https://www.jfcr.or.jp/laboratory/department/pathology/index.html
• [Remarks] （財団法人）がん研究会がん研究所病理部ホームページ
  • URL: http://www.jfcr.or.jp/laboratory/department/pathology/index.html
• [Remarks] （公財）がん研究会がん研究所病理部
  • URL: http://www.jfcr.or.jp/laboratory/department/pathology/index.html