Regulatory mechanism of ciliary protein Inversin by Akt
| Project/Area Number |
16K08705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Suizu Futoshi 北海道大学, 遺伝子病制御研究所, 准教授 (90431379)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Akt / Inversin / 細胞極性 / リン酸化 / 一次繊毛 / 嚢胞腎 |
|---|
| Outline of Final Research Achievements |
The Akt phosphorylation site amino acid sequence Thr-Ser-Thr (864-866) of human Inversin is conserved in higher animals such as primates, but not in animal groups such as mice, frogs and zebrafish. There was no effect on intracellular localization of Inversin or Wnt signal inhibitory activity. Thus, there would be no functional conservation of Inversin phosphorylation by Akt. Moreover, Inversin was found to be accumulated in some nuclear structure which likely to be a transcriptional activation center and has a specific transcription activity. Taken together, this study strongly suggests that Inversin functions as a novel transcriptional regulator.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果を足掛かりに、Inversinをはじめとした様々な繊毛タンパク群のこれまでに知られていない転写制御因子としての生物機能発見に繋がると考えている。そして、それらの生物機能の理解により、これまで未解明であった繊毛タンパク異常が引き起こす平面内細胞極性異常や繊毛病発症の分子メカニズム解明の道標になると考えている。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis.2017
Author(s)
Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley S-JB, Noguchi M, Hirata N, Suizu F, Yamada T, Kudo M, and Sakuragi N.
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Journal Title
Oncotarget
Volume: 8 (8)
Pages: 13509-13520
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1.2017
Author(s)
Funadani R＊, Sogame Y＊,(＊equal contributor) Kojima K, Takeshita T, Yamamoto K, Tsujizono T, Suizu F, Miyata S, Yagyu KI, Suzuki T, Arikawa M, Matsuoka T
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Journal Title
FEMS Microbiology Letters
Volume: 363
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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