| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Our previous analysis using mouse metastasis model identified EMU1 as a potential candidate of the metastasis-promoting genes. We sought to clarify the molecular function of EMU1 and the protein expression in the human tissues. Overexpression and knockdown studies demonstrated two novel molecular functions of EMU1; inhibition of cell-matrix adhesion and promotion of cell growth, whereas the high-expressor did not exhibited enhanced metastatic activity. Expression analysis revealed exclusive expression in the chief cells of the stomach and the beta-cells of the pancreatic islet in normal tissues. In cancers, EMU1 was expressed in breast and colon cancers with high incidence. Because of its limited expression in the normal tissues, cell-specific functions of this molecule are presumed. In addition, increased expression in human cancer cases implies that EMU1 may be a new molecular target in cancer therapy.
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