Economic evaluation of Chronic Kidney Disease (CKD) mass screening

• Project/Area Number: 16K08860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical sociology
• Research Institution: University of Tsukuba
• Principal Investigator: Kondo Masahide 筑波大学, 医学医療系, 教授 (70334068)
• Research Collaborator: OKUBO reiko ; HOSHI shu-ling
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性腎臓病 / CKD / 早期発見 / マススクリーニング / 費用対効果 / 医療経済学 / 特定健診 / 必須検査項目

Outline of Final Research Achievements

It is imperative for the society to detect early Chronic Kidney Disease (CKD). Renal function test desirable for mass screening need to be identified. This study aims to be a foundation for such a social decision making. In particular, dipstick hematuria test, which is not listed as a mandatory item under the Specific Health Check and Specific Health Guidance but quite often implemented, is considered. Cost-effectiveness analysis of making it mandatory with an economic model featuring IgA nephropathy produced its favourable cost-effectiveness.

Academic Significance and Societal Importance of the Research Achievements

特定健診・特定保健指導の枠組みのマススクリーニングにおいて尿潜血検査を行うことの意義については学術的には以前から議論の的になってきていたが、一方で、過半数の保険者（特定健診の実施主体）において行われてきている実態がある。マススクリーニングのような予防医療においては、費用対効果の観点からの評価が重要であるが、本研究の成果は、この過去から続く今日的課題に対する報告として、医療経済学の立場から実施することや実施を広げていくことを支持する知見として大きな意義をもっている。

Research Products

• [Journal Article] New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population (2019)
  • Author(s): Hirai Hiroyuki、Asahi Koichi、Yamaguchi Satoshi、Mori Hirotaka、Satoh Hiroaki、Iseki Kunitoshi、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Shibagaki Yugo、Kasahara Masato、Watanabe Tsuyoshi、Shimabukuro Michio
  • Journal Title: Sci Rep Volume: 9 Pages: 2813-2813
  • DOI: 10.1038/s41598-019-39049-w
  • Peer Reviewed / Open Access
• [Journal Article] Association between Prescription and Control Status of Dyslipidemia and Hypertension among Japanese Patients with Diabetes (2019)
  • Author(s): Sakamoto Miki、Edo Naoki、Takahashi Satoshi、Okamura Erina、Uno Kenji、Morita Koji、Ishikawa Toshio、Asahi Koichi、Iseki Kunitoshi、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Kimura Kenjiro、Ohashi Yasuo、Watanabe Tsuyoshi、Tsukamoto Kazuhisa
  • Journal Title: J Atheroscler Thromb Volume: in press Issue: 9 Pages: 805-820
  • DOI: 10.5551/jat.47597
  • NAID: 130007699922
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Hypertension on Aortic Artery Disease-Related Mortality ― 3.8-Year Nationwide Community-Based Prospective Cohort Study ― (2018)
  • Author(s): Otaki Yoichiro、Watanabe Tetsu、Konta Tsuneo、Watanabe Masafumi、Fujimoto Shouichi、Sato Yuji、Asahi Koichi、Yamagata Kunihiro、Tsuruya Kazuhiko、Narita Ichiei、Kasahara Masato、Shibagaki Yugo、Iseki Kunitoshi、Moriyama Toshiki、Kondo Masahide、Watanabe Tsuyoshi
  • Journal Title: Circ J Volume: 82 Issue: 11 Pages: 2776-2782
  • DOI: 10.1253/circj.cj-18-0721 10.1253/circj.CJ-18-0721
  • NAID: 40021697227
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population (2018)
  • Author(s): Ogata Emi、Asahi Koichi、Yamaguchi Satoshi、Iseki Kunitoshi、Sato Hiroaki、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Shibagaki Yugo、Kasahara Masato、Watanabe Tsuyoshi、Shimabukuro Michio
  • Journal Title: Sci Rep Volume: 8 Pages: 13927-13927
  • DOI: 10.1038/s41598-018-31744-4
  • Peer Reviewed / Open Access
• [Journal Article] Dipstick proteinuria and all-cause mortality among the general population (2018)
  • Author(s): Iseki Kunitoshi、Konta Tsuneo、Asahi Koichi、Yamagata Kunihiro、Fujimoto Shouichi、Tsuruya Kazuhiko、Narita Ichiei、Kasahara Masato、Shibagaki Yugo、Moriyama Toshiki、Kondo Masahide、Iseki Chiho、Watanabe Tsuyoshi
  • Journal Title: Clinical and Experimental Nephrology Volume: 22 Pages: 1331-1340
  • DOI: 10.1007/s10157-018-1587-x
  • Peer Reviewed
• [Journal Article] Glucosuria and all-cause mortality among general screening participants (2018)
  • Author(s): Iseki Kunitoshi、Konta Tsuneo、Asahi Koichi、Yamagata Kunihiro、Fujimoto Shouichi、Tsuruya Kazuhiko、Narita Ichiei、Kasahara Masato、Shibagaki Yugo、Moriyama Toshiki、Kondo Masahide、Iseki Chiho、Watanabe Tsuyoshi
  • Journal Title: Clinical and Experimental Nephrology Volume: 22 Pages: 850-859
  • DOI: 10.1007/s10157-017-1528-0
  • Peer Reviewed
• [Journal Article] Association of dipstick hematuria with all-cause mortality in the general population: results from the specific health check and guidance program in Japan (2018)
  • Author(s): Iseki K, Konta T, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Iseki C, Watanabe T
  • Journal Title: Nephrol Dial Transplant Volume: 33 Pages: 825-832
  • DOI: 10.1093/ndt/gfx213
  • Peer Reviewed
• [Journal Article] Association of Hypertriglyceridemia With the Incidence and Progression of Chronic Kidney Disease and Modification of the Association by Daily Alcohol Consumption (2017)
  • Author(s): Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kimura K, Kondo M, Asahi K, Ohashi Y, Watanabe T
  • Journal Title: J Ren Nutr Volume: 27 Pages: 381-394
  • DOI: 10.1053/j.jrn.2017.05.002
  • Peer Reviewed
• [Journal Article] Association between Overall Lifestyle Changes and the Incidence of Proteinuria: A Population-based, Cohort Study (2017)
  • Author(s): Wakasugi M, Kazama J, Narita I, Iseki K, Fujimoto S, Moriyama T, Yamagata K, Konta T, Tsuruya K, Asahi K, Kondo M, Kurahashi I, Ohashi Y, Kimura K, Watanabe T
  • Journal Title: Intern. Med. Volume: 56 Issue: 12 Pages: 1475-1484
  • DOI: 10.2169/internalmedicine.56.8006
  • NAID: 130006856811
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Body shape index: Sex-specific differences in predictive power for all-cause mortality in the Japanese population (2017)
  • Author(s): Sato Y, Fujimoto S, Konta T, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T
  • Journal Title: PLoS One Volume: 12 Pages: 1-14
  • DOI: 10.1371/journal.pone.0177779
  • Peer Reviewed / Open Access
• [Journal Article] Mortality risk among screened subjects of the specific health check and guidance program in Japan 2008-2012. (2017)
  • Author(s): Iseki K, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Konta T, Kasahara M, Shibagaki Y, Yoshida H, Moriyama T, Kondo M, Iseki C, Watanabe T.
  • Journal Title: Clin Exp Nephrol Volume: - Pages: 1-8
  • DOI: 10.1007/s10157-017-1392-y
  • Peer Reviewed
• [Journal Article] Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study. (2017)
  • Author(s): Kamei K, Konta T, Hirayama A, Ichikawa K, Kubota I, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T.
  • Journal Title: Clin Exp Nephrol Volume: - Pages: 497-503
  • DOI: 10.1007/s10157-016-1311-7
  • Peer Reviewed
• [Journal Article] Control Status of Atherosclerotic Cardiovascular Risk Factors Among Japanese High-Risk Subjects:Analyses of a Japanese Health Check Database from 2008 to 2011 (2016)
  • Author(s): Hasegawa K, Tsukamoto K, Kunimi M, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kimura K, Ohashi Y, Watanabe T.
  • Journal Title: J Atheroscler Thromb Volume: 23 Issue: 8 Pages: 991-1003
  • DOI: 10.5551/jat.31906
  • NAID: 130005254340
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Presentation] 地域住民の総死亡・心血管死亡における高尿酸血症の影響度について (2019)
  • Author(s): 大瀧陽一郎，今田恒夫，成田一衛，笠原正澄，柴垣有吾，守山敏樹，渡邉哲，渡辺昌文，藤元昭一，井関邦敏，山縣邦弘，鶴屋和彦，近藤正英，旭浩一，渡辺毅
  • Organizer: 第52回日本痛風・核酸代謝学会総会
• [Presentation] 特定健診受診者における血清尿酸値が大動脈疾患死に与える影響 (2019)
  • Author(s): 大瀧陽一郎，今田恒夫，成田一衛，笠原正澄，柴垣有吾，守山敏樹，渡邉哲，渡辺昌文，藤元昭一，井関邦敏，山縣邦弘，鶴屋和彦，近藤正英，旭浩一，渡辺毅
  • Organizer: 第52回日本痛風・核酸代謝学会総会
• [Presentation] Prediction Model for Cardiovascular Death Including Proteinuria and Estimated Glomerular Filtration Rate in a General Population (2018)
  • Author(s): Nishimoto M，Yamagata K，Konta T，Fujimoto S，Narita I，Kasahara M，Shibagaki Y，Moriyama T，Kondo M，Watanabe T， Tagawa M，Tsuruya K，Eriguchi M，Iseki K，Iseki C，Asahi K
  • Organizer: Kidney Week，2018
  • Int'l Joint Research
• [Presentation] 慢性腎臓病の有無による朝食を抜く食習慣と死亡の関係 (2018)
  • Author(s): 古澤彩美，村澤昌，内田大介，木戸亮，河原崎宏雄，渡辺毅，井関邦俊，守山敏樹，山縣邦弘，鶴屋和彦，今田恒夫，成田一衛，近藤正英，笠原正登，旭浩一，柴垣有吾
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] 慢性腎臓病の有無による歩行速度と死亡の関係 (2018)
  • Author(s): 村澤昌，古澤彩美，内田大介，木戸亮，河原崎宏雄，渡辺毅，井関邦敏，守山敏樹，山縣邦弘，鶴屋和彦，藤元昭一，今川 恒夫，成田一衛，近藤正英，笠原正登，旭浩一，柴垣有吾
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] Establishing a cost-effective community based screening for CKD. (2017)
  • Author(s): Masahide Kondo
  • Organizer: The 11th Asian forum of CKD initiative
  • Place of Presentation: Manila, Phillipines
  • Year and Date: 2017-03-16
  • Int'l Joint Research / Invited
• [Presentation] 特定健診データベースからみた高尿酸血症の頻度と関連因子 (2017)
  • Author(s): 今田恒夫、亀井啓太、守山敏樹、柴垣有吾、笠原正登、成田一衛、藤元昭一、井関邦敏、山縣邦弘、鶴屋和彦、近藤正英、旭浩一、渡辺毅
  • Organizer: 第50回日本痛風・核酸代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2017-02-16
• [Presentation] Mortality risk of renal glucosuria in a general screening participants in Japan (2017)
  • Author(s): K. Iseki, T. Konta, K. Asahi, K. Yamagata, S. Fujimoto, K. Tsuruya, I. Narita, M. Kasahara, Y. Shibagaki, T. Moriyama, M. Kondo, T. Watanabe
  • Organizer: American Society of Nephrology Kidney Week 2017
  • Int'l Joint Research
• [Presentation] 早食いにより糖尿病発症は増加する (2017)
  • Author(s): 工藤 明宏、岩崎 麻里子、尾形 絵美、佐藤 博亮、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、藤元 昭一、成田 一衛、今田 恒夫、近藤 正英、柴垣 有吾、笠原 正登、旭 浩一、渡辺 毅 島袋 充生
  • Organizer: 第38回日本肥満学会
• [Presentation] 運動習慣、食習慣の糖尿病新規発症に及ぼす影響 65歳未満群および65歳以上群での検討 (2017)
  • Author(s): 岩崎 麻里子、工藤 明宏、尾形 絵美、待井 典剛、佐藤 博亮、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、藤元 昭一、成田 一衛、今田 恒夫、近藤 正英、柴垣 有吾、笠原 正登、旭 浩一、渡辺 毅 島袋 充生
  • Organizer: 第38回日本肥満学会
• [Presentation] 食行動要因の糖尿病新規発症におよぼす影響 特定健診受診者における解析 (2017)
  • Author(s): 工藤 明宏、尾形 絵美、待井 典剛、佐藤 博亮、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、藤元 昭一、成田 一衛、今田 恒夫、近藤 正英、柴垣 有吾、笠原 正登、旭 浩一、渡辺 毅 島袋 充生
  • Organizer: 第６０回日本糖尿病学会年次学術集会
• [Presentation] 空腹時血糖レベル・HbA1cレベル別にみた新規糖尿病発症リスク (2017)
  • Author(s): 尾形 絵美、工藤 明宏、待井 典剛、佐藤 博亮、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、藤元 昭一、成田 一衛、今田 恒夫、近藤 正英、柴垣 有吾、笠原 正登、旭 浩一、渡辺 毅 島袋 充生
  • Organizer: 第６０回日本糖尿病学会年次学術集会
• [Presentation] 運動要因および食行動要因と糖尿病新規発症の関連 65歳未満群および65歳以上群での検討 (2017)
  • Author(s): 岩崎 麻里子、工藤 明宏、尾形 絵美、待井 典剛、佐藤 博亮、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、藤元 昭一、成田 一衛、今田 恒夫、近藤 正英、柴垣 有吾、笠原 正登、旭 浩一、渡辺 毅 島袋 充生
  • Organizer: 第６０回日本糖尿病学会年次学術集会
• [Presentation] 新しい体格指標であるABSIは日本人の男性では死亡を予測するが、CKD女性では予測しない (2017)
  • Author(s): 佐藤 祐二、藤元 昭一、今田 恒夫、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、成田 一衛、近藤 正英、笠原 正登、柴垣 有吾、旭 浩一、渡辺 毅
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] 死亡個票に基づく心脳血管病死亡に対する高血圧管理の影響 特定健診コホート解析 (2017)
  • Author(s): 永井 恵、斎藤 知栄、井関 邦敏、守山 敏樹、鶴屋 和彦、藤元 昭一、成田 一衛、今田 恒夫、近藤 正英、笠原 正登、柴垣 有吾、旭 浩一、山縣 邦弘、渡辺 毅
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] CKDをもつ地域住民における血清尿酸値と生命予後の関連 (2017)
  • Author(s): 亀井 啓太、近 壮一朗、市川 一誠、今田 恒夫、藤元 昭一、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、成田 一衛、近藤 正英、笠原 正登、柴垣 有吾、旭 浩一、渡辺 毅
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] Chronic kidney disease and the association of self-assessed lifestyle behaviors with mortality in a large Japanese general population (2017)
  • Author(s): A. Furusawa1, R. Kido, M. Murasawa, D. Uchida, S. Fujimoto, K. Iseki, T. Moriyama, K. Yamagata, K. Tsuruya, T. Konta, I. Narita, M. Kondo, M. Kasahara, K. Asahi, T. Watanabe, Y. Shibagaki, H. Kawarazaki
  • Organizer: 54th European Renal Association - European Dialysis and Transplant Association Congress
  • Int'l Joint Research
• [Presentation] Association of dipstick proteinuria with all cause mortality in general population: results from the specific health check and guidance program in Japan (2017)
  • Author(s): K. Iseki, T. Konta, K. Asahi, K. Yamagata, S. Fujimoto, K. Tsuruya, I. Narita, M. Kasahara, Y. Shibagaki, T. Moriyama, M. Kondo, C. Iseki, T. Watanabe
  • Organizer: 54th European Renal Association - European Dialysis and Transplant Association Congress
  • Int'l Joint Research
• [Presentation] The association between serum uric acid and mortality in the CKD population: a longitudinal survey of a nationwide cohort in Japan (2017)
  • Author(s): K. Kamei, S. Kon, K. Ichikawa, T. Konta, I. Kubota, S. Fujimoto, K. Iseki,.T. Moriyama, K. Yamagata, K. Tsuruya, I. Narita, M. Kondo, M. Kasahara, Y. Shibagaki, K. Asahi, T. Watanabe
  • Organizer: 54th European Renal Association - European Dialysis and Transplant Association Congress
  • Int'l Joint Research
• [Presentation] Antihypertensive treatment and risk of cardio-vascular mortality in patients with chronic kidney disease (2017)
  • Author(s): K. Nagai, C. Saito, K. Asahi, K. Iseki, T. Moriyama, K. Tsuruya, S. Fujimoto, I. Narita, T. Konta, M. Kondo, M. Kasahara, Y. Shibagaki, K. Yamagata, T. Watanabe
  • Organizer: 54th European Renal Association - European Dialysis and Transplant Association Congress
  • Int'l Joint Research
• [Presentation] Anemia as a risk factor for all-cause mortality; obscure synergic effect of chronic kidney disease (2017)
  • Author(s): Y. Sato, S. Fujimoto, T. Konta, K. Iseki, T. Moriyama, K. Yamagata, K. Tsuruya, I. Narita, M. Kondo, M. Kasahara, Y. Shibagaki, K. Asahi, T. Watanabe
  • Organizer: 54th European Renal Association - European Dialysis and Transplant Association Congress
  • Int'l Joint Research
• [Presentation] Expected risk of death by CKD stage using stochastic linkage between death certificates and the Specific Health Check Programme Cohort in Japan (2016)
  • Author(s): Masahide Kondo, Mariko Yamamura, Chiho Iseki, Kunitoshi Iseki, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Toshiki Moriyama, Ichiei Narita, Tsuneo Konta, Yugo Shibagaki, Masato Kasahara, Tsuyoshi Watanabe
  • Organizer: 53rd ERA-EDTA Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] The association between serum uric acid and incidence of non-fatal stroke in the CKD population: a longitudinal survey of a netionwide cohort in Japan (2016)
  • Author(s): Keita Kamei, Akira Araumi, Sayumi Watanabe, Hiroko Sato, Kazunobu Ichikawa, Tsuneo Konta, Isao Kubota, Kunitoshi Iseki, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Toshiki Moriyama, Yugo Shibagaki, Koichi Asahi, Masahide Kondo, Masato Kasahara, Tsuyoshi Watanabe
  • Organizer: 53rd ERA-EDTA Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-05-21
  • Int'l Joint Research