| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Nitroglycerin has reported to induce oxidative stress and impairs endothelial function. Aldehyde dehydrogenase 2 (ALDH2) is an anti-oxidative enzyme, and its activity is lost in the Glu504Lys (*2) genotype. We reported that this genotype impaired endothelial function after continuous administration of nitroglycerin in ALDH2 *2/*2 carriers. Quercetin is a dietary polyphenol which has anti-oxidative effect. In this study, we revealed that co-administration of quercetin improved endothelial function after continuous treatment of nitroglycerin even in ALDH2 *2/*2 carriers.
|
