Clinical application of high sensitive biomarker and therapeutic target for lung cancer
| Project/Area Number |
16K08928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Atsushi Takano 東京大学, 医科学研究所, 特任講師 (50582607)
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| Co-Investigator(Kenkyū-buntansha) |
醍醐 弥太郎 滋賀医科大学, 医学部, 教授 (30345029)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 高感度バイオマーカー / 肺がん / バイオマーカー / 新規治療標的分子 / トランスレーショナルリサーチ / 癌 / 遺伝子 / マイクロアレイ / 臨床 |
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| Outline of Final Research Achievements |
Immunohistochemical staining showed that URST1 expression was observed in the majority of lung cancer, oral cancer and breast cancer. URST1 expression was associated with poor prognosis for cancer patients. Reduction of URST1 expression by siRNA for URST1 (si-URST1) significantly suppressed growth of cancer cells through G2/M arrest. In addition, exposure of cancer cells to selective URST1 inhibitor suppressed the cell growth. In addtion, we revealed that KIF11 was prognostic factor for oral cancer. si-KIF11 and KIF11 inhibitor suppressed the growth of cancer cells.
Regarding to high sensitive biomarker, we detected URST1 mRNA in the majority of serum exosome and lung cancer tissues derived from 20 lung cancer patients.
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| Academic Significance and Societal Importance of the Research Achievements |
上記の候補を含めて、約10種類の予後マーカー、治療標的分子について研究を進めており、阻害剤を用いたin vitroの検討において、がんの増殖抑制効果を確認できており、治癒可能性が低い進行がんの治癒、延命に向けて有効な治療法のひとつとなりうると考えられる。また、予後マーカーを用いて予後を予測することで高危険度群の選別して、徹底した経過観察、治療強度の選択の一助になるものと考えられる。血清中Exosomeを抽出しmRNA、タンパクを検出することは、これまでのバイオマーカーの検出限界を超えうるものである。
新規治療薬、早期診断により、効果的な治療計画を選択すれば、医療費の削減にもつながると考えられる。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Maternal undernutrition during early pregnancy inhibits postnatal growth of the tibia in the female offspring of rats by alteration of chondrogenesis.2018
Author(s)
Kimura T, Hino K, Kono T, Takano A, Nitta N, Ushio N, Hino S, Takase R, Kudo M, Daigo Y, Morita W, Nakao M, Nakatsukasa M, Tamagawa T, Rafiq AM, Matsumoto A, Otani H, Udagawa J.
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Journal Title
Gen Comp Endocrinol.
Volume: 260
Issue: 1
Pages: 58-60
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers2018
Author(s)
Baghdadi M, Endo H, Takano A, Ishikawa K, Kameda Y, Wada H, Miyagi Y, Yokose T, Ito H, Nakayama H, Daigo Y, Suzuki N, Seino K
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Journal Title
Sci Rep.
Volume: 11;8(1)
Issue: 1
Pages: 418-418
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells.2016
Author(s)
Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino KI.
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Journal Title
Cancer Research
Volume: 76
Pages: 6030-6042
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.2016
Author(s)
Shiraishi K, Takahashi A, Takano A, Watanabe Y, Hishida T, Tsuchihara K, Miyagi Y, Tanaka K, Imai K, Minamiya Y, Sakamoto H, Inazawa J, Nakamura Y, Yoshida T, Yokota J, Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T, et. al.
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Journal Title
Nature Communications
Volume: 7
Pages: 12451-12451
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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