Extraction of the high risk individuals of non-alcoholic fatty liver disease in metabolic syndrome using the new index.

• Project/Area Number: 16K09057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SOGABE Masahiro 徳島大学, 大学院医歯薬学研究部(医学域), 特任講師 (60732790)
• Co-Investigator(Kenkyū-buntansha): 中川 忠彦 島根県立大学, 看護栄養学部, 助教 (40634275) ; 岡久 稔也 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授 (60304515)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: メタボリック症候群 / 非アルコール性脂肪性肝疾患 / メタボローム解析 / 質的内臓脂肪 / 検診 / メタボリックシンドローム / NAFLD

Outline of Final Research Achievements

e aimed to extract of the high risk individuals of non-alcoholic fatty liver disease (NAFLD) in metabolic syndrome (MS) using quality of internal fat and metabolomics analysis. We found that the frequency of cases with ALT elevation and NAFLD in visceral type MS was significantly higher than that in subcutaneous type MS. We showed that NAFLD with ALT elevation might be associated with total fat area, several markers of insulin resistance, liver fibrosis, inflammatory, and several metabolites such as nicotinamide.

Academic Significance and Societal Importance of the Research Achievements

メタボリック症候群（MS）は生活習慣病を合併するだけでなく、非アルコール性脂肪性肝疾患（NAFLD）の発症との関連も指摘されるようになり、MS該当者における適切な指導や経過観察は重要な課題となっている。しかし、MS該当者は予備群を含めると約2000 万人であり全員に保健指導などを行うことは現実的に不可能である。そこで今回我々はMS該当者において、いくつかのNAFLDとの関連項目・物質を見出し、これらの成果を健診に加味することでMS該当者における高リスクなNAFLD症例を抽出できうる可能性が示唆された。

Research Products

• [Journal Article] The differing influence of several factors on the development of fatty liver with elevation of liver enzymes between genders with metabolic syndrome: A cross-sectional study. (2017)
  • Author(s): Sogabe M, Okahisa T, Nakasono M, Fukuno H, Miyamoto Y, Okada Y, Okazaki J, Miyoshi J, Tomonari T, Taniguchi T, Goji T, Kitamura S, Miyamoto H, Muguruma N, Takayama T.
  • Journal Title: PLoS One Volume: 12 Issue: 6 Pages: e0177925-e0177925
  • DOI: 10.1371/journal.pone.0177925
  • NAID: 120006534962
  • Peer Reviewed / Open Access
• [Journal Article] Influence of metabolic syndrome on upper gastrointestinal disease. (2016)
  • Author(s): Sogabe M, Okahisa T, Kimura T, Okamoto K, Miyamoto H, Muguruma N, Takayama T.
  • Journal Title: Clin J Gastroenterol. Volume: 9 Issue: 4 Pages: 191-202
  • DOI: 10.1007/s12328-016-0668-1
  • Peer Reviewed
• [Presentation] Influence of Lifestyle and Lifestyle-Related Disease on Nonalcoholic Fatty Liver Disease in Japanese with Metabolic Syndrome. (2016)
  • Author(s): 1.Sogabe M, Okahisa T, Nakagawa N, Murayama N, Takehara M, Kagemoto K, Takaoka Y, Tomonari T, Taniguchi T, Kimura T, Muguruma N, Takayama T.
  • Organizer: DDW2016
  • Place of Presentation: 「San Diego (米国)」
  • Year and Date: 2016-05-21
  • Int'l Joint Research