Health effects of PM2.5 and its composition on arrhythmia and heart rate variability

• Project/Area Number: 16K09097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kyoto University
• Principal Investigator: Ueda Kayo 京都大学, 地球環境学堂, 准教授 (60444717)
• Co-Investigator(Kenkyū-buntansha): 早野 順一郎 名古屋市立大学, 医薬学総合研究院(医学), 教授 (90173054) ; 植田 典浩 名古屋大学, 環境医学研究所, 助教 (10456709) ; 清野 健 大阪大学, 基礎工学研究科, 教授 (40434071)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大気汚染 / 健康影響 / 循環器疾患 / 心電図 / 心拍変動 / PM2.5 / 自律神経 / 疫学 / 粒子状物質 / 成文分析 / 微小粒子状物質

Outline of Final Research Achievements

In order to evaluate the effects of PM2.5 exposure on autonomic nervous system, we used the data of Allostatic State Mapping by Ambulatory ECG Repository （ALLSTAR）study which includes the data of heart rate variability(HRV) obtained by Holter ECG in the several prefectures, and combined with PM2.5 concentration. HRV reflects the balance of autonomic nervous system.
In the statistical analysis, we found that higher PM2.5 concentration was associated with lower HRV indices, which could increase the risk of cardiovascular diseases and sudden deaths. The association persisted for a few days. This study elucidated the mechanism by which exposure to ambient particulate air pollution trigger cardiovascular disease through autonomic nervous system by epidemiological approaches.

Academic Significance and Societal Importance of the Research Achievements

大気汚染物質曝露が呼吸器疾患だけでなく、循環器疾患や心臓突然死を増やす可能性があることが、国内の疫学研究でも報告されるようになってきた。一方で、そのメカニズムの詳細は十分わかっていない。本研究では、全国数万規模の心電図情報を用いた統計解析で、そのメカニズムの一つを明らかにした。この知見は、大気汚染による健康影響低減のための対策に資することとなる。
また、本研究を通じて心電図情報が整備されており、医工学の連携も図られた。

Research Products

• [Journal Article] Association between PM2.5 exposure and heart rate variability for the patients with cardiac problems in Japan (2020)
  • Author(s): Kanawat Paoin, Kayo Ueda, Xerxes Tesoro Seposo, Junichiro Hayano, Ken Kiyono, Norihiro Ueda, Takashi Kawamura, Akiko Honda & Hirohisa Takano
  • Journal Title: Air Qual Atmos Health Volume: 13 Issue: 3 Pages: 339-347
  • DOI: 10.1007/s11869-020-00797-8
  • Peer Reviewed / Open Access
• [Journal Article] Effects of ambient air pollution on daily hospital admissions for respiratory and cardiovascular diseases in Bangkok, Thailand (2019)
  • Author(s): Phosri Arthit、Ueda Kayo、Phung Vera Ling Hui、Tawatsupa Benjawan、Honda Akiko、Takano Hirohisa
  • Journal Title: Science of The Total Environment Volume: 651 Pages: 1144-1153
  • DOI: 10.1016/j.scitotenv.2018.09.183
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Acute Effects of Ambient PM2.5 on All-Cause and Cause-Specific Emergency Ambulance Dispatches in Japan (2018)
  • Author(s): Phung Vera、Ueda Kayo、Kasaoka Shunji、Seposo Xerxes、Tasmin Saira、Yonemochi Shinichi、Phosri Arthit、Honda Akiko、Takano Hirohisa、Michikawa Takehiro、Nitta Hiroshi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 15 Issue: 2 Pages: 307-307
  • DOI: 10.3390/ijerph15020307
  • NAID: 120006501342
  • Peer Reviewed / Open Access
• [Presentation] Long-term air pollution exposure and risk factors for cardiovascular diseases in Thailand (the electricity generating authority of Thailand study) using epidemiological approaches: a longitudinal cohort study (2020)
  • Author(s): Kanawat P, Ueda K, Vathesatogkit P, et al.
  • Organizer: Prince Mahidol Award Conference 2020
  • Int'l Joint Research
• [Presentation] Associations of Particle Compositions with Emergency Ambulance Dispatches in Osaka, Japan. (2019)
  • Author(s): 2.Uttajug A, Ueda K, Takami A, Yoshino A, Sugata S, Michikawa T, Yamazaki S, Nitta H, Honda A, Takano H.
  • Organizer: ISEE-ISES AC 2019（韓国）10月17-19日
  • Int'l Joint Research
• [Presentation] The association between pm2.5 and heart rate variability in Japan (2018)
  • Author(s): Kanawat Paoin, Kayo Ueda, Xerxes Tesoro Seposo1, Hayano Junichiro, Kiyono Ken, Ueda Norihiro, Kawamura Takashi, Hirohisa Takano
  • Organizer: International Society of Environmental Epidemiology Asian Chapter 2018
  • Int'l Joint Research
• [Presentation] Regional heterogeneity in the association of short-term exposure to PM2.5 with ambulance dispatches due to acute illnesses (2018)
  • Author(s): 上田佳代 、Seposo Xerxus、Phung Vera Ling Hui、高見昭憲、吉野彩子、菅田誠治、道川武紘, 4)、山崎新、新田裕史
  • Organizer: 第89回日本衛生学会
• [Presentation] Exploring the regional variation in the associaton of fine particulate matter and emergency ambulance dispatches in Japan (2018)
  • Author(s): Kayo Ueda, Vera L.H. Phung, Xerxes T. Seposo, Akinori Takami, Seiji Sugata, Ayako Yoshino
  • Organizer: Better Air Quality 2018
  • Int'l Joint Research
• [Presentation] PM2.5の健康影響-身近な疑問から最新の研究結果まで- (2018)
  • Author(s): 上田佳代, Seposo Xerxes
  • Organizer: 第59回大気環境学会年会
• [Presentation] Effects of short-term exposure to ambient air pollution on hospital admissions for acute myocardial infarction in Bangkok, Thailand (2017)
  • Author(s): A. Phosri, K. Ueda, Phung VLH, S. Yasukouchi, T. Sugiyama, L. Paoin, K. Kotani, H. Hasegawa, A. Honda, H. Takano
  • Organizer: International Society of Environmental Epidemiology 2017
  • Int'l Joint Research
• [Presentation] 大気汚染が循環器疾患発症に及ぼす影響の疫学研究における曝露評価 (2017)
  • Author(s): 上田佳代
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited