Identification of metastasis-associated genes based on methylome and chromosome analyses and it's clinical application

• Project/Area Number: 16K09382
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kindai University
• Principal Investigator: NISHIDA Naoshi 近畿大学, 医学部, 准教授 (60281755)
• Research Collaborator: KUDO Masatoshi ; KAIDO Toshimi ; TANAKA Shinji
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝細胞癌 / 転移 / ゲノム / エピゲノム / クロモゾーム / 化学療法 / 遺伝子変異 / メチローム / 分子分類 / 転移再発 / 分子スコア / アジュバント療法 / 遺伝子

Outline of Final Research Achievements

We clarify molecular features of aggressive HCC, and establish a molecular scoring system that predicts metastasis after curative treatment. In total, 125 HCCs were examined for genome methylome and chromosomal analyses; molecular subclasses and risk score were determined. Next, HCC patients who underwent liver transplantation were analyzed for molecular risk score and metastatic recurrence; survival analyses were validated using a dataset of 376 HCC cases from the Cancer Genome Atlas (TCGA). Molecular risks, that consisted with presence of TP53 mutation, high FAL, global hypomethylation, and absence of CTNNB1 mutation were noted to predict shorter recurrence-free survival in both liver transplantation cohort (p = 0.0090 by log-rank test). and TCGA cohort (p = 0.0076). We concluded that molecular score could predict metastatic recurrence after curative treatments, and could be a marker for considering systemic therapy for HCC patients.

Academic Significance and Societal Importance of the Research Achievements

近年、肝癌の薬物療法は急速に発展し、肝動脈塞栓術(TACE)の奏効率に近づいている。一方、TACEは肝機能を悪化させるため、TACE後の転移再発のリスクの高い群では薬物療法を先行させるべきとの考えが広がっている。しかし、現在、TACE後の転移再発を予測することは困難である。さらに、肝切除においても、転移再発のリスクの高い群ではアジュバント、ネオアジュバントとしての薬物療法の適応を考慮すべきである。本研究成果は、肝癌転移再発の高リスク群を同定する分子スコアの開発であり、肝癌のマネージメントにおける意義は大きい。

Research Products

• [Journal Article] Liver damage related to immune checkpoint inhibitors. (2019)
  • Author(s): Nishida N, Kudo M
  • Journal Title: Hepatol Int Volume: 印刷中 Issue: 3 Pages: 248-252
  • DOI: 10.1007/s12072-018-9921-7
  • Peer Reviewed
• [Journal Article] Current status and perspectives for computer-aided ultrasonic diagnosis of liver lesions using deep learning technology. (2019)
  • Author(s): Nishida N, Yamakawa M, Shiina T, Kudo M.
  • Journal Title: Hepatol Int. Volume: 印刷中 Issue: 4 Pages: 416-421
  • DOI: 10.1007/s12072-019-09937-4
  • Peer Reviewed
• [Journal Article] Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection. (2019)
  • Author(s): Komeda Y, Watanabe T, Sakurai T, Kono M, Okamoto K, Nagai T, Takenaka M, Hagiwara S, Matsui S, Nishida N, Tsuji N, Kashida H, Kudo M.
  • Journal Title: World J Gastroenterol Volume: 25 Pages: 1502-1512
  • Peer Reviewed / Open Access
• [Journal Article] Sustained antiviral effects and clearance of hepatitis surface antigen after combination therapy with entecavir and pegylated interferon in chronic hepatitis B. (2018)
  • Author(s): Hagiwara S, Nishida N, Watanabe T, Ida H, Sakurai T, Ueshima K, Takita M, Komeda Y, Nishijima N, Osaki Y, Kudo M.
  • Journal Title: Antivir Ther. Volume: 23 Issue: 6 Pages: 513-521
  • DOI: 10.3851/imp3225
  • Peer Reviewed
• [Journal Article] Value of additional endoscopic ultrasonography for surveillance after surgical removal of intraductal papillary mucinous neoplasms. (2018)
  • Author(s): Kamata K, Takenaka M, Minaga K, Omoto S, Miyata T, Yamao K, Imai H, Nakai A, Tanaka H, Chiba Y, Watanabe T, Sakurai T, Nishida N, Chikugo T, Matsumoto I, Takeyama Y, Kitano M, Kudo M.
  • Journal Title: Dig Endosc Volume: 印刷中 Issue: 5 Pages: 659-666
  • DOI: 10.1111/den.13176
  • NAID: 130007635776
  • Peer Reviewed / Open Access
• [Journal Article] Cystic duct antegrade stenting for cholangitis after the long-term deployment of lumen-apposing metal stents for calculous cholecystitis. (2018)
  • Author(s): Kamata K, Takenaka M, Minaga K, Nakai A, Omoto S, Miyata T, Yamao K, Imai H, Sakurai T, Watanabe T, Nishida N, Kudo M.
  • Journal Title: Endosc Ultrasound Volume: 7 Issue: 8 Pages: 349-350
  • DOI: 10.1111/hepr.13191
  • Peer Reviewed / Open Access
• [Journal Article] Molecular Scoring of Hepatocellular Carcinoma for Predicting Metastatic Recurrence and Requirements of Systemic Chemotherapy. (2018)
  • Author(s): Nishida N, Nishimura T, Kaido T, Minaga K, Yamao K, Kamata K, Takenaka M, Ida H, Hagiwara S, Minami Y, Sakurai T, Watanabe T, Kudo M.
  • Journal Title: Cancers (Basel) Volume: 29 Issue: 10 Pages: 10-10
  • DOI: 10.3390/cancers10100367
  • Peer Reviewed / Open Access
• [Journal Article] Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer. (2018)
  • Author(s): Sakurai T, Komeda Y, Nagai T, Kamata K, Minaga K, Yamao K, Takenaka M, Hagiwara S, Watanabe T, Nishida N, Kashida H, Nakagawa K, Kudo M.
  • Journal Title: Digestion. Volume: 4 Issue: 3 Pages: 1-9
  • DOI: 10.1159/000494969
  • Peer Reviewed / Open Access
• [Journal Article] Association between the Risk Factors for Pancreatic Ductal Adenocarcinoma and Those for Malignant Intraductal Papillary Mucinous Neoplasm (2017)
  • Author(s): Kamata Ken、Takenaka Mamoru、Nakai Atsushi、Omoto Shunsuke、Miyata Takeshi、Minaga Kosuke、Matsuda Tomohiro、Yamao Kentaro、Imai Hajime、Chiba Yasutaka、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Chikugo Takaaki、Matsumoto Ippei、Takeyama Yoshifumi、Kudo Masatoshi
  • Journal Title: Oncology Volume: 93 Issue: Suppl. 1 Pages: 102-106
  • DOI: 10.1159/000481234
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Bmi1 Expression in Inflammatory Bowel Disease (2017)
  • Author(s): Yamada Mitsunari、Sakurai Toshiharu、Komeda Yoriaki、Nagai Tomoyuki、Kamata Ken、Minaga Kosuke、Yamao Kentaro、Takenaka Mamoru、Hagiwara Satoru、Matsui Shigenaga、Watanabe Tomohiro、Nishida Naoshi、Kashida Hiroshi、Kudo Masatoshi
  • Journal Title: Oncology Volume: 93 Issue: Suppl. 1 Pages: 20-26
  • DOI: 10.1159/000481225
  • Peer Reviewed / Open Access
• [Journal Article] Oncogenic Signal and Tumor Microenvironment in Hepatocellular Carcinoma (2017)
  • Author(s): Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Oncology Volume: 93 Issue: Suppl. 1 Pages: 160-164
  • DOI: 10.1159/000481246
  • Peer Reviewed / Open Access
• [Journal Article] Ultrasound-ultrasound image overlay fusion improves real-time control of radiofrequency ablation margin in the treatment of hepatocellular carcinoma (2017)
  • Author(s): Minami Yasunori、Minami Tomohiro、Hagiwara Satoru、Ida Hiroshi、Ueshima Kazuomi、Nishida Naoshi、Murakami Takamichi、Kudo Masatoshi
  • Journal Title: European Radiology Volume: 28 Issue: 5 Pages: 1986-1993
  • DOI: 10.1007/s00330-017-5162-8
  • Peer Reviewed
• [Journal Article] Role of Immune Checkpoint Blockade in the Treatment for Human Hepatocellular Carcinoma (2017)
  • Author(s): Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis Volume: 35 Issue: 6 Pages: 618-622
  • DOI: 10.1159/000480258
  • Peer Reviewed
• [Journal Article] Sorafenib-Regorafenib Sequential Therapy in Advanced Hepatocellular Carcinoma: A Single-Institute Experience (2017)
  • Author(s): Ueshima Kazuomi、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 611-617
  • DOI: 10.1159/000480257
  • Peer Reviewed
• [Journal Article] Time to Transcatheter Arterial Chemoembolization Refractoriness in Patients with Hepatocellular Carcinoma in Kinki Criteria Stages B1 and B2 (2017)
  • Author(s): Arizumi Tadaaki、Minami Tomohiro、Chishina Hirokazu、Kono Masashi、Takita Masahiro、Yada Norihisa、Hagiwara Satoru、Minami Yasunori、Ida Hiroshi、Ueshima Kazuomi、Kamata Ken、Minaga Kosuke、Komeda Yoriaki、Takenaka Mamoru、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 589-597
  • DOI: 10.1159/000480208
  • Peer Reviewed
• [Journal Article] Impact of Tumor Factors on Survival in Patients with Hepatocellular Carcinoma Classified Based on Kinki Criteria Stage B2 (2017)
  • Author(s): Arizumi Tadaaki、Minami Tomohiro、Chishina Hirokazu、Kono Masashi、Takita Masahiro、Yada Norihisa、Hagiwara Satoru、Minami Yasunori、Ida Hiroshi、Ueshima Kazuomi、Kamata Ken、Minaga Kosuke、Komeda Yoriaki、Takenaka Mamoru、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 583-588
  • DOI: 10.1159/000480186
  • Peer Reviewed
• [Journal Article] Hepatocellular Carcinoma after Achievement of Sustained Viral Response with Daclatasvir and Asunaprevir in Patients with Chronic Hepatitis C Virus Infection (2017)
  • Author(s): Ida Hiroshi、Hagiwara Satoru、Kono Masashi、Minami Tomohiro、Chishina Hirokazu、Arizumi Tadaaki、Takita Masahiro、Yada Norihisa、Minami Yasunori、Ueshima Kazuomi、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 565-573
  • DOI: 10.1159/000480183
  • Peer Reviewed
• [Journal Article] Unique Characteristics Associated with Sustained Liver Damage in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals (2017)
  • Author(s): Kono Masashi、Nishida Naoshi、Hagiwara Satoru、Minami Tomohiro、Chishina Hirokazu、Arizumi Tadaaki、Minaga Kosuke、Kamata Ken、Komeda Yoriaki、Sakurai Toshiharu、Takenaka Mamoru、Takita Masahiro、Yada Norihisa、Ida Hiroshi、Minami Yasunori、Ueshima Kazuomi、Watanabe Tomohiro、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 556-564
  • DOI: 10.1159/000480148
  • Peer Reviewed
• [Journal Article] Hepatocarcinogenesis Is Associated with Serum Albumin Levels after Sustained Virological Responses with Interferon-Based Therapy in Patients with Hepatitis C (2017)
  • Author(s): Umehara Yasuko、Hagiwara Satoru、Nishida Naoshi、Sakurai Toshiharu、Ida Hiroshi、Minami Yasunori、Takita Masahiro、Minami Tomohiro、Chishina Hirokazu、Ueshima Kazuomi、Komeda Yoriaki、Arizumi Tadaaki、Watanabe Tomohiro、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 548-555
  • DOI: 10.1159/000480147
  • Peer Reviewed
• [Journal Article] Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis (2017)
  • Author(s): Hagiwara Satoru、Nishida Naoshi、Park Ah-Mee、Komeda Yoriaki、Sakurai Toshiharu、Watanabe Tomohiro、Kudo Masatoshi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 10440-10440
  • DOI: 10.1038/s41598-017-10570-0
  • Peer Reviewed / Open Access
• [Journal Article] Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of localized gallbladder lesions (2017)
  • Author(s): Kamata Ken、Takenaka Mamoru、Kitano Masayuki、Omoto Shunsuke、Miyata Takeshi、Minaga Kosuke、Yamao Kentaro、Imai Hajime、Sakurai Tosiharu、Nishida Naoshi、Kashida Hiroshi、Chikugo Takaaki、Chiba Yasutaka、Nakai Takuya、Takeyama Yoshifumi、Lisotti Andrea、Fusaroli Pietro、Kudo Masatoshi
  • Journal Title: Digestive Endoscopy Volume: 30 Issue: 1 Pages: 98-106
  • DOI: 10.1111/den.12900
  • NAID: 130007485238
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Overall Survival of Patients with Hepatocellular Carcinoma Correlates with the Newly Defined Time to Progression after Transarterial Chemoembolization (2017)
  • Author(s): Arizumi Tadaaki、Ueshima Kazuomi、Iwanishi Mina、Minami Tomohiro、Chishina Hirokazu、Kono Masashi、Takita Masahiro、Yada Norihisa、Hagiwara Satoru、Minami Yasunori、Ida Hiroshi、Komeda Yoriaki、Takenaka Mamoru、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Liver Cancer Volume: 6 Issue: 3 Pages: 227-235
  • DOI: 10.1159/000475777
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Liver Inflammation on Liver Stiffness Measurement in Patients with Autoimmune Hepatitis Evaluation by Combinational Elastography (2017)
  • Author(s): Yada Norihisa、Sakurai Toshiharu、Minami Tomohiro、Arizumi Tadaaki、Takita Masahiro、Hagiwara Satoru、Ida Hiroshi、Ueshima Kazuomi、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Oncology Volume: 92 Issue: Suppl. 1 Pages: 10-15
  • DOI: 10.1159/000451011
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Epigenetic Alterations in Human Hepatocellular Carcinoma and Its Association with Genetic Mutations. (2016)
  • Author(s): Nishida N, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 708-713
  • DOI: 10.1159/000448863
  • Peer Reviewed / Open Access
• [Journal Article] 1.2.Impact of Tight Junction Protein ZO-1 and TWIST Expression on Postoperative Survival of Patients with Hepatocellular Carcinoma. (2016)
  • Author(s): Nagai T, Arao T, Nishio K, Matsumoto K, Hagiwara S, Sakurai T, Minami Y, Ida H, Ueshima K, Nishida N, Sakai K, Saijo N, Kudo K, Kaneda H, Tamura D, Aomatsu K, Kimura H, Fujita Y, Haji S, Kudo M.
  • Journal Title: Dig Dis. Volume: 34 Issue: 6 Pages: 702-707
  • DOI: 10.1159/000448860
  • Peer Reviewed / Open Access
• [Journal Article] US-US Fusion Imaging in Radiofrequency Ablation for Liver Metastases. (2016)
  • Author(s): Minami Y, Minami T, Chishina H, Kono M, Arizumi T, Takita M, Yada N, Hagiwara S, Ida H, Ueshima K, Nishida N, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 687-691
  • DOI: 10.1159/000448857
  • Peer Reviewed / Open Access
• [Journal Article] Validation of Kinki Criteria, a Modified Substaging System, in Patients with Intermediate Stage Hepatocellular Carcinoma. (2016)
  • Author(s): Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Minami Y, Ida H, Sakurai T, Kitano M, Nishida N, Kudo M
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 671-678
  • DOI: 10.1159/000448834
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Factors Predicting the Effect of Tolvaptan for Refractory Ascites in Patients with Decompensated Liver Cirrhosis. (2016)
  • Author(s): Chishina H, Hagiwara S, Nishida N, Ueshima K, Sakurai T, Ida H, Minami Y, Takita M, Kono M, Minami T, Iwanishi M, Umehara Y, Watanabe T, Komeda Y, Arizumi T, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 659-664
  • DOI: 10.1159/000448828
  • Peer Reviewed / Open Access
• [Journal Article] Monoethanolamine Oleate Sclerotherapy for Polycystic Liver Disease. (2016)
  • Author(s): Takita M, Iwanishi M, Minami T, Kono M, Chishina H, Arizumi T, Yada N, Hagiwara S, Minami Y, Ida H, Ueshima K, Naoshi N, Kudo M.
  • Journal Title: Dig Dis. Volume: 34 Issue: 6 Pages: 654-658
  • DOI: 10.1159/000448826
  • Peer Reviewed / Open Access
• [Journal Article] Prospective Risk Analysis of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C by Ultrasound Strain Elastography. (2016)
  • Author(s): Yada N, Sakurai T, Minami T, Arizumi T, Takita M, Hagiwara S, Ida H, Ueshima K, Nishida N, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 650-653
  • DOI: 10.1159/000448865
  • Peer Reviewed / Open Access
• [Journal Article] Safety, Tolerability, and Efficacy of Sofosbuvir Plus Ribavirin in Elderly Patients Infected with Hepatitis C Virus Genotype 2. (2016)
  • Author(s): Nishida N, Kono M, Minami T, Chishina H, Arizumi T, Takita M, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 632-639
  • DOI: 10.1159/000448824
  • Peer Reviewed / Open Access
• [Journal Article] Outcome of Asunaprevir/Daclatasvir Combination Therapy for Chronic Liver Disease Type C. (2016)
  • Author(s): Hagiwara S, Nishida N, Watanabe T, Sakurai T, Ida H, Minami Y, Takita M, Minami T, Iwanishi M, Chishina H, Ueshima K, Komeda Y, Arizumi T, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 620-626
  • DOI: 10.1159/000448822
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of anti-migration properties of biliary covered self-expandable metal stents. (2016)
  • Author(s): Minaga K, Kitano M, Imai H, Harwani Y, Yamao K, Kamata K, Miyata T, Omoto S, Kadosaka K, Sakurai T, Nishida N, Kudo M.
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 30 Pages: 6917-24
  • DOI: 10.3748/wjg.v22.i30.6917
  • Peer Reviewed / Open Access
• [Journal Article] Survival Benefit of Locoregional Treatment for Hepatocellular Carcinoma with Advanced Liver Cirrhosis. (2016)
  • Author(s): Kitai S, Kudo M, Nishida N, Izumi N, Sakamoto M, Matsuyama Y, Ichida T, Nakashima O, Matsui O, Ku Y, Kokudo N, Makuuchi M; Liver Cancer Study Group of Japan.
  • Journal Title: Liver Cancer Volume: 5 Issue: 3 Pages: 175-89
  • DOI: 10.1159/000367765
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of pain response in patients undergoing endoscopic ultrasound-guided neurolysis for abdominal pain caused by pancreatic cancer. (2016)
  • Author(s): Minaga K, Kitano M, Sakamoto H, Miyata T, Imai H, Yamao K, Kamata K, Omoto S, Kadosaka K, Sakurai T, Nishida N, Chiba Y, Kudo M.
  • Journal Title: Therap Adv Gastroenterol. Volume: 9 Pages: 483-94
  • Peer Reviewed / Open Access
• [Journal Article] Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease. (2016)
  • Author(s): Nishida N, Yada N, Hagiwara S, Sakurai T, Kitano M, Kudo M.
  • Journal Title: J Gastroenterol Hepatol Volume: 31 Issue: 9 Pages: 1646-53
  • DOI: 10.1111/jgh.13318
  • Peer Reviewed / Open Access
• [Presentation] Stem cell feature and immune-suppressive microenvironment in human hepatocellular carcinoma (2018)
  • Author(s): Nishida N, Kudo M
  • Organizer: American Association for the Study of Liver Diseases (AASLD) 2018
  • Int'l Joint Research
• [Presentation] ここまで進んだ肝癌の薬物療法 (2018)
  • Author(s): 西田直生志
  • Organizer: Japan Digestive Disease Week 2018
  • Invited
• [Presentation] 人工知能の利活用を見据えた超音波デジタル画像のビッグデータベース構築基盤整備 ―AI支援型超音波診断システムの開発に向けて― (2018)
  • Author(s): 西田直生志
  • Organizer: 第30回日本超音波医学会関東甲信越地方会学術集会 特別シンポジウム
  • Invited
• [Presentation] The Expression of Immune Checkpoint Molecules in HCC Tumor Tissues -Clinicopathological feature of PD-L1-positive HCC- (2018)
  • Author(s): Nishida N
  • Organizer: 2018 CHA Liver Center International Symposium Immuno-Oncology for Liver Cancer, Comes of Age!
  • Int'l Joint Research / Invited
• [Presentation] PD-L1陽性肝癌の特徴と腫瘍免疫環境に関する解析 (2018)
  • Author(s): 西田直生志
  • Organizer: 第18回日本肝がん分子標的治療研究会
• [Presentation] 遺伝子変化に基づいた肝細胞癌の分子スコアリングと転移再発 (2018)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第54回肝臓学会総会 シンンポジウム1
• [Presentation] RFAの効果判定： Hepatic Guideの有用性 (2018)
  • Author(s): 南知宏、南康範、河野匡志、千品寛和、有住忠晃、田北雅弘、萩原智、依田広、上嶋一臣、西田直生志、工藤正俊
  • Organizer: 第54回肝臓学会総会
• [Presentation] 慢性C型肝炎のDAA投与例におけるSVR後のAFP、ALT異常及び肝発癌に関する検討 (2018)
  • Author(s): 河野匡志、西田直生志、千品寛和、田北雅弘、萩原智、依田広、南康範、上嶋一臣、工藤正俊
  • Organizer: 第54回肝臓学会総会 ワークショップ11
• [Presentation] Studies on AFP, ALT Abnormalities and Hepatocarcinogenesis after SVR in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals (2018)
  • Author(s): Kono M, Nishida N, Ida H, Minami T, Chishina H, Takita M, Hagiwara S, Minami Y, Ueshima K, Kudo M
  • Organizer: APASL single topic conference on HCC 「hepatitis C」
  • Int'l Joint Research
• [Presentation] US-US image overlay fusion を用いたラジオ波焼灼術の早期治療効果判定 (2018)
  • Author(s): 南康範、西田直生志、工藤正俊
  • Organizer: 第104回日本消化器病学会総会 シンポジウム6
• [Presentation] 2nd generation targeted therapy and immune check-point inhibitor for advanced HCC (2017)
  • Author(s): Naoshi Nishida
  • Organizer: The 2nd MYONJI International Liver Symposium
  • Int'l Joint Research / Invited
• [Presentation] Clinicopathological characteristics and mutational profile of PD-L1 positive hepatocellular carcinoma (2017)
  • Author(s): Nishida N and Kudo M
  • Organizer: 68th Annual meeting of the American Association for the Study of Liver Diseases (AASLD). Parallel Session 22: Hepatocarcinogenesis
  • Int'l Joint Research
• [Presentation] PD-L1陽性肝癌の臨床病理学的特徴と遺伝子変異プロファイル (2017)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第103回日本消化器病学会総会 シンポジウム8「肝発癌メカニズムのパラダイムシフトとこれからの展望」
• [Presentation] US-US image fusion を用いた肝細胞癌へのラジオ波焼灼術の有用性 (2017)
  • Author(s): 南康範、西田直生志、工藤正俊
  • Organizer: 第103回日本消化器病学会総会 ワークショップ12「肝画像診断の進歩
• [Presentation] Locked Nucleic Acidsを用いた 血清中マイクロRNA定量と ソラフェニブ治療に対する反応予測 (2017)
  • Author(s): 西田直生志、岩西美奈、南知宏、千品寛和、河野匡志、有住忠晃、田北雅弘、矢田典久、依田広、萩原智、南康範、上嶋一臣、工藤正俊
  • Organizer: 第15回日本肝がん分子標的治療研究会（優秀演題
• [Presentation] DAA投与におけるSVR後のAFP異常値と関連する臨床背景の検討 (2017)
  • Author(s): 河野匡志、西田直生志、千品寛和、南知宏、有住忠晃、田北雅弘、矢田典久、萩原智、南康範、上嶋一臣、工藤正俊
  • Organizer: 第42回肝臓学会西部会
• [Presentation] 胃への遠隔転移を認めた肝細胞癌の一例 (2017)
  • Author(s): 福永朋洋、萩原智、半田康平、高田隆太朗、岡本彩奈、南知宏、河野匡志、千品寛和、有住忠晃、田北雅弘、南康範、依田広、上嶋一臣、西田直生志、工藤正俊
  • Organizer: 第42回肝臓学会西部会
• [Presentation] 真性多血症にBudd-Chiari症候群を伴った一例 (2017)
  • Author(s): 高田隆太朗、萩原智、福永朋洋、半田康平、岡本彩奈、南知宏、河野匡志、千品寛和、有住忠晃、田北雅弘、南康範、依田広、上嶋一臣、西田直生志、工藤正俊
  • Organizer: 第42回肝臓学会西部会
• [Presentation] 腹壁静脈瘤破裂に対して直接穿刺にて硬化療法を施行した２例 (2017)
  • Author(s): 半田康平、萩原智、福永朋洋、高田隆太朗、岡本彩奈、南知宏、河野匡志、千品寛和、有住忠晃、田北雅弘、南康範、依田広、上嶋一臣、西田直生志、工藤正俊
  • Organizer: 第42回肝臓学会西部会
• [Presentation] DAA投与におけるSVR後のAFP及びALT異常値と関連する臨床背景の検討 (2017)
  • Author(s): 河野匡志、西田直生志、南知宏、千品寛和、有住忠晃、田北雅弘、依田広、矢田典久、南康範、萩原智、上嶋一臣、工藤正俊
  • Organizer: 第53回肝臓学会総会
• [Presentation] US-US overlay image fusion を用いた肝細胞癌へのラジオ波焼灼術の有用性:従来法との比較 (2017)
  • Author(s): 南康範、西田直生志、工藤正俊
  • Organizer: 第53回肝臓学会総会
• [Presentation] Identification of fetal liver-type hepatocellular carcinoma based on a methylome analysis and its association with genetic alterations. (2016)
  • Author(s): Naoshi Nishida N, Masatoshi Kudo
  • Organizer: 第24回日本消化器関連学会週間（第20回日本肝臓学会大会） International Session, Symposium 1. 「Genetics of hepatocellular carcinoma: Hepatitis virus infection and hepatocarcinogenesis 」
  • Place of Presentation: 神戸ポートピアホテル (神戸)
  • Year and Date: 2016-11-03
• [Presentation] ゲノム・エピゲノム・染色体情報に基づいた肝癌の亜分類と転移再発予測 (2016)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第52回日本肝癌研究会 パネルディスカッション 2 肝細胞癌の新たなサブクラス分類と治療ストラテジー
  • Place of Presentation: 虎の門ヒルズフォーラム (東京)
  • Year and Date: 2016-07-01
• [Presentation] NASH 関連肝発癌における線維化進展と遺伝子変化 (2016)
  • Author(s): 萩原智、西田直生志、工藤正俊
  • Organizer: 第52回日本肝癌研究会ワークショップ 2 非ウイルス性肝細胞癌の病態と分類
  • Place of Presentation: 虎の門ヒルズフォーラム (東京)
  • Year and Date: 2016-07-01
• [Presentation] Immunotherapy for HCC; hype or hope (2016)
  • Author(s): Naoshi Nishida
  • Organizer: The 1st MYONJI International Liver Symposium
  • Place of Presentation: Myongji Hospital (Seoul, Korea)
  • Int'l Joint Research / Invited
• [Book] Diagnosis of Liver Disease (2019)
  • Author(s): Nishida N, Kita R, Miyosh K, Koda M, Iwai M, Suriawinata AA
  • Total Pages: 52
  • Publisher: Springer Nature
  • ISBN: 9789811368059
• [Book] ESMO HANDBOOK OF IMMUNO-ONCOLOGY (2018)
  • Author(s): Nishida N
  • Total Pages: 11
  • Publisher: European Society of Medical Oncology
  • ISBN: 9788894179576
• [Book] The Liver Cancer Journal (2018)
  • Author(s): 西田直生志、工藤正俊
  • Total Pages: 5
  • Publisher: メディカルレビュー社
• [Book] 肝胆膵 (2018)
  • Author(s): 西田直生志、工藤正俊
  • Total Pages: 7
  • Publisher: アークメディア
• [Book] Medical Science Digest 肝細胞癌治療の最前線 (2017)
  • Author(s): 西田直生志
  • Total Pages: 5
  • Publisher: 北隆館
• [Book] 肝胆膵 特集 肝硬変を理解する-分子機構から実臨床に至るまで- I.疫学 2.成因別肝細胞癌合併頻度：経年的変化 (2016)
  • Author(s): 西田直生志、工藤正俊
  • Total Pages: 8
  • Publisher: アークメディア
• [Funded Workshop] American Association for Study of Liver Diseases (2018)