Research Project
Grant-in-Aid for Scientific Research (C)
In this research project, RNF43 gene knockout mice were generated and analyzed. RNF43 encodes an E3 ubiquitin ligase and negatively regulates Wnt signaling. RNF43 KO mice were born according to Mendelian frequency, and there was no difference in their growth as compared to wild. As RNF43 somatic mutations of RNF43 are found in 18% or more of colon cancer and endometrial cancer (Nat Genet, 2014), azoxymethane (AOM) and DSS were administered to mice (AOM / DSS mice) As a result of examining whether there is a difference in cancer carcinogenesis, it was found that the tumor was large and that RNF43 had the function of suppressing the progression of colorectal cancer.
IPMNではKRAS、GNAS、RNF43遺伝子の変異が重複して見られる。今回はRNF43に関して、そのノックアウトマウスを作製し、単独欠損では膵臓に異常を来さないこと、また大腸発がんモデルを用いると、やはりRNF43が腫瘍発生に抑制的に働いていることが明らかとなった。今後はIPMNに関してもその分子メカニズムを解明することで、新たな治療法の開発につながると予想される。
All 2019 2018 2017 2016
All Journal Article (14 results) (of which Int'l Joint Research: 6 results, Peer Reviewed: 14 results, Open Access: 8 results, Acknowledgement Compliant: 4 results) Presentation (9 results) (of which Int'l Joint Research: 2 results, Invited: 1 results) Book (1 results)
Oncogene.
Volume: 38 Pages: 1211-1224
10.1038/s41388-018-0510-y
J Pathol.
Volume: 245 Pages: 445-455
10.1002/path.5098
Elife.
Volume: 7 Pages: 36572-36572
10.7554/elife.36572
Biochem Biophys Res Commun.
Volume: 505 Pages: 453-459
10.1016/j.bbrc.2018.09.128
Sci Immunol.
Volume: 3
10.1126/sciimmunol.aat0207
J Clin Oncol.
Volume: 印刷中 Pages: 3485-3494
10.1200/jco.2018.79.0352
Nature Commun
Volume: 8 Pages: 1-10
10.1038/s41467-017-01311-y
120007134656
Surgery Today
Volume: 47 Pages: 1104-1110
10.1007/s00595-017-1485-y
Surgical Case Reports
Volume: - Pages: 31-31
10.1186/s40792-017-0308-0
Hepatology
Volume: 65 Pages: 237-252
10.1002/hep.28878
120006528815
Sci Rep
Volume: 6 Pages: 37200-37200
10.1038/srep37200
Proc Natl Acad Sci U S A
Volume: 113 Pages: 13432-13437
Immunity.
Volume: 45 Pages: 1245-1257
10.1016/j.immuni.2016.10.012
Nat. Commun.
Volume: 7 Pages: 12756-12756
10.1038/ncomms12756
120006535062