| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Clinical evidence demonstrated that it was impossible to prevent atherosclerotic cardiovascular events effectively by controlling the conventional coronary risk factors. Recently, chronic inflammation in atherogenesis was became the focus of attention not only as a cause of initiation and progression of atherosclerosis but also as a therapeutic target. In this research project, we demonstrated ultra violet B exposure systemically increased regulatory T cells through induction of tolerogenic dendritic cells in the skin, resulted in inducing immune tolerance, and inhibited atherosclerosis or aneurysm formation in mice. We would like to develop this method as a novel therapeutic strategy.
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