Development of novel methods for prevention of atherosclerosis through inducing immune-tolerance.
| Project/Area Number |
16K09516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
Sasaki Naoto
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫寛容 / 動脈硬化 / 腸内細菌叢 / 紫外線 / 炎症 / 制御性T細胞 / 乳酸菌 / 腸内細菌 |
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| Outline of Final Research Achievements |
Clinical evidence demonstrated that it was impossible to prevent atherosclerotic cardiovascular events effectively by controlling the conventional coronary risk factors. Recently, chronic inflammation in atherogenesis was became the focus of attention not only as a cause of initiation and progression of atherosclerosis but also as a therapeutic target. In this research project, we demonstrated ultra violet B exposure systemically increased regulatory T cells through induction of tolerogenic dendritic cells in the skin, resulted in inducing immune tolerance, and inhibited atherosclerosis or aneurysm formation in mice. We would like to develop this method as a novel therapeutic strategy.
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| Academic Significance and Societal Importance of the Research Achievements |
紫外線を皮膚に照射する治療法は、皮膚疾患の治療法として臨床応用されている。本研究では、この紫外線照射治療をマウスではあるが動脈硬化の予防法として利用できるのではないかと考えて実施した。紫外線照射は、皮膚から免疫寛容を誘導し、制御性T細胞という炎症を制御する免疫担当細胞を増加させることで動脈硬化が予防できることが判明した。この新規治療法の開発を行って、臨床応用できれば、患者負担の少ない治療法となり、医学的にも社会的にも貢献度は大きい。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Bacteroides Vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis2018
Author(s)
Naofumi Yoshida, Takuo Emoto, Tomoya Yamashita, Hikaru Watanabe, Tomohiro Hayashi, Tokiko Tabata, Namiko Hoshi, Naoya Hatano, Genki Ozawa, Naoto Sasaki, Taiji Mizoguchi, Hilman Zulkifli Amin, Yushi Hirota, Wataru Ogawa, Takuji Yamada, Ken-ichi Hirata
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Journal Title
Circulation
Volume: 138
Pages: 2486-2498
DOI
Related Report
Peer Reviewed
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[Journal Article] UVB exposure inhibits angiotensin II-induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells.2017
Author(s)
Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, AminHZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori T, Rikitake Y, Hirata K.
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Journal Title
J Am Heart Assoc.
Volume: 6
DOI
Related Report
Peer Reviewed
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[Journal Article] Oral administration of the lactic acid bacterium Pediococcus acidilactici attenuates atherosclerosis in mice by inducing tolerogenic dendritic cells.2017
Author(s)
Mizoguchi T, Kasahara K, Yamashita T, Sasaki N, Yodoi K, Matsumoto T, Emoto T, Hayashi T, Kitano N, Yoshida N, Amin HZ, Hirata K.
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Journal Title
Heart Vessels
Volume: 32
Pages: 768-776
DOI
Related Report
Peer Reviewed
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[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
Author(s)
Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 37(1)
Pages: 66-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016
Author(s)
Takuya Matsumoto, Naoto Sasaki, Tomoya Yamashita, Takuo Emoto, Kazuyuki Kasahara, Taiji Mizoguchi, Tomohiro Hayashi, Keiko Yodoi, Naoki kitano, Takashi Saito, Tomoyuki Yamaguchi, and Ken-ichi Hirata
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 36
Pages: 1141-1151
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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