Lineage relationship between PP cells and beta cells
| Project/Area Number |
16K09765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
原 朱美 順天堂大学, 医学部, その他 (60570009)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | PP細胞 / β細胞 / 糖尿病 / リプログラミング / 転写因子 / 膵島 / 発生・分化 / 膵β細胞 |
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| Outline of Final Research Achievements |
PP cells are one type of endocrine cells that exist in pancreatic islets. So far, the relationship between PP cells and other endocrine cells has not been well understood. By conducting lineage tracing experiments of PP cells, it was revealed that these cells have the characteristic of endocrine precursor cells that they can differentiate into any type of endocrine cells including β cells. Furthermore, it was suggested that there are at least two differentiating pathways leading to β cells, that is, a pathway through PP cells and a pathway unrelated to PP cells. Furthermore, from loss-of-function and overexpression experiments of transcription factors, it was shown that Pdx1 and MafA cooperate in the process of differentiation of PP-expressing cells into β cells.
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| Academic Significance and Societal Importance of the Research Achievements |
我々の研究を通じて、β細胞の分化過程においては、PP細胞を経由してβ細胞に分化する新奇分化経路が存在することが明らかとなった。β細胞が喪失した糖尿病患者においてもPP細胞は残存することから、PP細胞を起源としてβ細胞へとリプログラミングさせることによる新たな再生治療法に期待が持てると考えられる。
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Report
(5 results)
Research Products
(78 results)
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[Journal Article] Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide2019
Author(s)
Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.
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Journal Title
Endocr J
Volume: in press
Issue: 5
Pages: 459-468
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.2018
Author(s)
Osonoi Y, Mita T, Azuma K, Nakajima K, Masuyama A, Goto H, Nishida Y, Miyatsuka T, Fujitani Y, Koike M, Mitsumata M, Watada H.
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Journal Title
Autophagy
Volume: 14
Pages: 1991-2006
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.2017
Author(s)
Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
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Journal Title
PLoS Genetics
Volume: 13(8)
Pages: 1-23
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study.2017
Author(s)
Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H.
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Journal Title
Sci Rep
Volume: 9
Pages: 3676-3684
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP).2016
Author(s)
Fujitani Y, Fujimoto S, Takahashi K, Satoh H, Hirose T, Hiyoshi T, Ai M, Okada Y, Gosho M, Mita T, Watada H.
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Journal Title
Diabetes Res Clin Pract.
Volume: 121
Pages: 146-156
Related Report
Peer Reviewed
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[Journal Article] Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2.2016
Author(s)
Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H.
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Journal Title
J Clin Endocrinol Metab.
Volume: 101
Pages: 3676-3684
Related Report
Peer Reviewed
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[Journal Article] Relationship between dietary patterns and risk factors for cardiovascular disease in patients with type 2 diabetes mellitus: a cross-sectional study.2016
Author(s)
Osonoi Y, Mita T, Osonoi T, Saito M, Tamasawa A, Nakayama S, Someya Y, Ishida H, Kanazawa A, Gosho M, Fujitani Y, Watada H.
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Journal Title
Nutr J.
Volume: 15
Pages: 15-15
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Defect of autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.2017
Author(s)
Yusuke Osonoi , Tomoya Mita, Kosuke Azuma, Kenichi Nakajima, Atsushi Masuyama, Yuuya Nishida, Takeshi Miyatsuka, Yoshio Fujitani, Masato Koike, Masako Mitsumata, Hirotaka Watada
Organizer
The 8th International Symposium on Autophagy
Related Report
Int'l Joint Research
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[Book] 肝胆膵2016
Author(s)
福中彩子、藤谷与士夫
Total Pages
308
Publisher
株式会社アークメディア
Related Report
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