Effects of diabetes-related lipid dysregulation in astrocytes on cognitive functions
| Project/Area Number |
16K09776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Tokyo Medical University (2018)
The University of Tokyo (2016-2017) |
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Principal Investigator |
Suzuki Ryo 東京医科大学, 医学部, 准教授 (20396732)
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| Research Collaborator |
Chou Shengpu
Watanabe Ryusuke
Terai Ai
Kamei Nozomu
Kadowaki Takashi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / 脳脂質代謝 / コレステロール合成 / SCAP / AMPK / 内科 / 脳・神経 / 脂質 / 細胞・組織 |
|---|
| Outline of Final Research Achievements |
Brain from a subject with diabetes mellitus exhibits elevated activity of AMPK and reduction of SCAP. AMPK signaling potentially promotes transport of SCAP-SREBP complex from ER to Golgi via Rab2 pathway. Reduction of SCAP in astrocytes can inhibit growth and maturation of adjacent neurons.
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| Academic Significance and Societal Importance of the Research Achievements |
糖尿病が認知機能を低下させるメカニズムは未だ不明な点が多い。アストロサイトにおけるエネルギー状態と脂質代謝の変化によってニューロンの成熟状態が影響を受ける新規分子経路を提唱する結果である。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] The RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis.2019
Author(s)
Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K
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Journal Title
Gastrointest. Tumors
Volume: 38
Pages: 81-91
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of an Automatic Puncturing and Sampling System for a Self-Monitoring Blood Glucose Device2017
Author(s)
Abe-Doi M, Oe M, Murayama R, Takahashi M, Zushi Y, Tanabe H, Takamoto I, Suzuki R, Yamauchi T, Kadowaki T, Komiyama C, Sanada H
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Journal Title
Diabetes Technol Ther
Volume: 19
Pages: 651-659
DOI
Related Report
Peer Reviewed
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[Journal Article] Willingness of patients with diabetes to use an ICT-based self-management tool: a cross-sectional study2017
Author(s)
Shibuta T, Waki K, Tomizawa N, Igarashi A, Yamamoto-Mitani N, Yamaguchi S, Fujita H, Kimura S, Fujiu K, Waki H, Izumida Y, Sasako T, Kobayashi M, Suzuki R, Yamauchi T, Kadowaki T, Ohe K.
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Journal Title
BMJ Open Diabetes Research & Care
Volume: 5
DOI
Related Report
Peer Reviewed / Open Access
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