| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Endothelial cells are known to regulate adiposity by lipid uptake from the blood circulation to white adipocytes. However, the mechanism underlying the regulation of endothelial transport by systemic energy balance remains unclear. Ghrelin, a gastric peptide, conveys nutritional information and increases adiposity mainly through the central nervous system. The deficiency of its receptor, growth hormone secretagogue-receptor (GHSR), leads to reduced adiposity after high fat intake.
This study demonstrated that endothelial GHSR plays an important role in endothelial function and controls lipid metabolism in response to ghrelin. The findings also suggest that the endothelium regulates white adipocyte metabolism.
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