Multimodal language processing and a novel parameter of language development during childhood

• Project/Area Number: 16K09991
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: Sanefuji Masafumi 九州大学, 環境発達医学研究センター, 特任准教授 (50467940)
• Co-Investigator(Kenkyū-buntansha): 伊良皆 啓治 九州大学, システム情報科学研究院, 教授 (20211758) ; 山下 洋 九州大学, 大学病院, 学術研究員 (20253403)
• Project Period (FY): 2016-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 発達 / 言語情報処理 / 眼球運動追跡装置 / 言語

Outline of Final Research Achievements

This study mainly aimed to investigate the neural basis of multimodal language processing during childhood using an eye tracking system in a prospective cohort. We made a novel task that is optimal for 4-years-old children and obtained the data from over 200 children. To appropriately interpret the results of this task, we demonstrated the relationship between the results of an eyetracker-based task and a neuropsychological test and further conducted simultaneous monitoring with eyetracker and event-related potential and found the neural correlates of information processing in adult subjects.

Academic Significance and Societal Importance of the Research Achievements

本研究では、アイトラッカーを用いて言語タスク時の眼球運動を、２歳、４歳に加えて、６歳でもデータ収集を完遂することができた。また利き手や神経心理検査のデータも得られており、これを合わせて解析することにより、年齢に応じたマルチモーダル言語情報処理の神経基盤が明らかになると考えられる。また、その神経基盤が異なることが予測される自閉スペクトラム症など発達障害を持つ児に、適切な言語養育環境を提供できる可能性を有している。

Research Products

• [Journal Article] Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis (2021)
  • Author(s): Sonoda Yuri、Sonoda Motoshi、Yonemoto Kousuke、Sanefuji Masafumi、Taira Ryoji、Motomura Yoshitomo、Ishimura Masataka、Torisu Hiroyuki、Kira Ryutaro、Kusuhara Koichi、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Journal of Neuroimmunology Volume: 358 Pages: 577656-577656
  • DOI: 10.1016/j.jneuroim.2021.577656
  • Peer Reviewed / Open Access
• [Journal Article] Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study (2021)
  • Author(s): Tetsuhara Kenichi、Kaku Noriyuki、Watanabe Yuka、Kumamoto Masaya、Ichimiya Yuko、Mizuguchi Soichi、Higashi Kanako、Matsuoka Wakato、Motomura Yoshitomo、Sanefuji Masafumi、Hiwatashi Akio、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 12090-12090
  • DOI: 10.1038/s41598-021-91628-y
  • Peer Reviewed / Open Access
• [Journal Article] Vitamin A deficiency?associated corneal perforation in a boy with autism spectrum disorder: A case report and literature review (2021)
  • Author(s): Adachi Shunichi、Torio Michiko、Okuzono Sayaka、Motomura Yoshitomo、Ichimiya Yuko、Sonoda Yuri、Nagata Jyunya、Okamoto Misato、Notomi Shoji、Sanefuji Masafumi、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Nutrition Volume: 90 Pages: 111275-111275
  • DOI: 10.1016/j.nut.2021.111275
  • Peer Reviewed / Open Access
• [Journal Article] Age-related morphological differences in the spike-and-wave complexes of absence epilepsy (2021)
  • Author(s): Sonoda Yuri、Sanefuji Masafumi、Ichimiya Yuko、Torio Michiko、Watanabe Eriko、Sakata Ayumi、Ishizaki Yoshito、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Epilepsy Research Volume: 174 Pages: 106647-106647
  • DOI: 10.1016/j.eplepsyres.2021.106647
  • Peer Reviewed / Open Access
• [Journal Article] GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons. (2020)
  • Author(s): Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani M, Kato TA, Ishitani T, Kato H, Masuda K, Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S.
  • Journal Title: FASEB J Volume: 34 Issue: 12 Pages: 16601-16621
  • DOI: 10.1096/fj.202001113r
  • Peer Reviewed / Open Access
• [Journal Article] De novo p.G696S mutation in COL4A1 causes intracranial calcification and late-onset cerebral hemorrhage: A case report and review of the literature. (2020)
  • Author(s): Kinoshita K, Ishizaki Y, Yamamoto H, Sonoda M, Yonemoto K, Kira R, Sanefuji M, Ueda A, Matsui H, Ando Y, Sakai Y, Ohga S.
  • Journal Title: Eur J Med Genet Volume: 63 Issue: 4 Pages: 103825-103825
  • DOI: 10.1016/j.ejmg.2019.103825
  • Peer Reviewed
• [Journal Article] The association between gut microbiota development and maturation of intestinal bile acid metabolism in the first 3 y of healthy Japanese infants. (2020)
  • Author(s): Tanaka M, Sanefuji M, Morokuma S, Yoden M, Momoda R, Sonomoto K, Ogawa M, Kato K, Nakayama J.
  • Journal Title: Gut Microbes Volume: 11 Issue: 2 Pages: 205-216
  • DOI: 10.1080/19490976.2019.1650997
  • Peer Reviewed
• [Journal Article] Management of apnea in infants with trisomy 18. (2019)
  • Author(s): Taira R, Inoue H, Sawano T, Fujiyoshi J, Ichimiya Y, Torio M, Sanefuji M, Ochiai M, Sakai Y, Ohga S.
  • Journal Title: Dev Med Child Neurol Volume: in press Issue: 7 Pages: 119-125
  • DOI: 10.1111/dmcn.14403
  • Peer Reviewed
• [Journal Article] Decision-making dilemmas of paediatricians: a qualitative study in Japan. (2019)
  • Author(s): Sasazuki M, Sakai Y, Kira R, Toda N, Ichimiya Y, Akamine S, Torio M, Ishizaki Y, Sanefuji M, Narama M, Itai K, Hara T, Takada H, Kizawa Y, Ohga S.
  • Journal Title: BMJ Open Volume: 9 Issue: 8 Pages: e026579-e026579
  • DOI: 10.1136/bmjopen-2018-026579
  • Peer Reviewed / Open Access
• [Journal Article] An acute encephalopathy with reduced diffusion in BRAF-associated cardio-facio-cutaneous syndrome (2019)
  • Author(s): Okuzono Sayaka、Fukai Ryoko、Noda Marie、Miyake Noriko、Lee Sooyoung、Kaku Noriyuki、Sanefuji Masafumi、Akamine Satoshi、Kanno Shunsuke、Ishizaki Yoshito、Torisu Hiroyuki、Kira Ryutaro、Matsumoto Naomichi、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Brain and Development Volume: 41 Issue: 4 Pages: 378-381
  • DOI: 10.1016/j.braindev.2018.10.012
  • Peer Reviewed
• [Journal Article] Vascular pathomechanism in acute encephalopathy with biphasic seizures and late reduced diffusion (2018)
  • Author(s): Sanefuji Masafumi、Ichimiya Yuko、Kaku Noriyuki、Sasazuki Momoko、Yonemoto Kosuke、Torio Michiko、Mizuguchi Soichi、Motomura Yoshitomo、Muraoka Mamoru、Lee Sooyoung、Baba Haruhisa、Ohkubo Kazuhiro、Sonoda Yuri、Ishizaki Yoshito、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Journal of the Neurological Sciences Volume: 395 Pages: 141-146
  • DOI: 10.1016/j.jns.2018.10.007
  • Peer Reviewed
• [Journal Article] A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan (2018)
  • Author(s): Nanishi Etsuro、Hoshina Takayuki、Sanefuji Masafumi、Kadoya Ryo、Kitazawa Katsuhiko、Arahata Yukie、Sato Tetsuya、Hirayama Yoshimichi、Hirai Katsuki、Yanai Masaaki、Nikaido Kaori、Maeda Akihiko、Torisu Hiroyuki、Okada Kenji、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Clinical Infectious Diseases Volume: in press Issue: 12 Pages: 2099-2104
  • DOI: 10.1093/cid/ciy816
  • Peer Reviewed
• [Journal Article] A rightward saccade to an unexpected stimulus as a marker for lateralised visuospatial attention (2018)
  • Author(s): Sanefuji Masafumi、Yamashita Hiroshi、Torio Michiko、Katsuki Daisuke、Akamine Satoshi、Ishizaki Yoshito、Kishimoto Junji、Sakai Yasunari、Takada Hidetoshi、Yoshida Keiko、Ohga Shouichi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 7562-7562
  • DOI: 10.1038/s41598-018-25890-y
  • Peer Reviewed / Open Access
• [Journal Article] Predictive indicators for the development of epilepsy after acute encephalopathy with biphasic seizures and late reduced diffusion (2018)
  • Author(s): Ichimiya Yuko、Kaku Noriyuki、Sanefuji Masafumi、Torio Michiko、Mizuguchi Soichi、Motomura Yoshitomo、Muraoka Mamoru、Lee Sooyoung、Baba Haruhisa、Sonoda Yuri、Ishizaki Yoshito、Sasazuki Momoko、Sakai Yasunari、Maehara Yoshihiko、Ohga Shouichi
  • Journal Title: Epilepsy Research Volume: 143 Pages: 70-74
  • DOI: 10.1016/j.eplepsyres.2018.04.006
  • Peer Reviewed
• [Journal Article] Early Intervention With Adrenocorticotropin for Acute Encephalopathy-Associated Epileptic Spasms: Report of Two Cases (2018)
  • Author(s): Yonemoto Kousuke、Ichimiya Yuko、Sanefuji Masafumi、Kaku Noriyuki、Sakata Ayumi、Baba Rieko、Yamashita Fumiya、Akamine Satoshi、Torio Michiko、Ishizaki Yoshito、Maehara Yoshihiko、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Clinical EEG and Neuroscience Volume: 50 Issue: 1 Pages: 51-55
  • DOI: 10.1177/1550059418786381
  • Peer Reviewed
• [Journal Article] Optimal protein intake during pregnancy for reducing the risk of fetal growth restriction: the Japan Environment and Children’s Study (2018)
  • Author(s): Morisaki Naho、Nagata Chie、Yasuo Shinobu、Morokuma Seiichi、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Senju Ayako、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi、Japan Environment and Children’s Study Group
  • Journal Title: British Journal of Nutrition Volume: 120 Issue: 12 Pages: 1432-1440
  • DOI: 10.1017/s000711451800291x
  • Peer Reviewed
• [Journal Article] Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children’s Study: A cohort study (2018)
  • Author(s): Morokuma Seiichi、Michikawa Takehiro、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Senju Ayako、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 15853-15853
  • DOI: 10.1038/s41598-018-34231-y
  • Peer Reviewed / Open Access
• [Journal Article] A male case with CDKL5 -associated encephalopathy manifesting transient methylmalonic acidemia (2018)
  • Author(s): Akamine Satoshi、Ishizaki Yoshito、Sakai Yasunari、Torisu Hiroyuki、Fukai Ryoko、Miyake Noriko、Ohkubo Kazuhiro、Koga Hiroshi、Sanefuji Masafumi、Sakata Ayumi、Kimura Masahiko、Yamaguchi Seiji、Sakamoto Osamu、Hara Toshiro、Saitsu Hirotomo、Matsumoto Naomichi、Ohga Shouichi
  • Journal Title: European Journal of Medical Genetics Volume: in press Issue: 8 Pages: 451-454
  • DOI: 10.1016/j.ejmg.2018.03.003
  • Peer Reviewed
• [Journal Article] Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2 (2017)
  • Author(s): Akamine S、Sagata N、Sakai Y、Kato TA.、Nakahara T、Matsushita Y、Togao O、Hiwatashi A、Sanefuji M、Ishizaki Y、Torisu H、Saitsu H、Matsumoto N、Hara T、Sawa A、Kano S、Furue M、Kanba S、Shaw CA.、Ohga S
  • Journal Title: Epilepsia Open Volume: 3 Issue: 1 Pages: 81-85
  • DOI: 10.1002/epi4.12085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative study on three different methods for arm-span measurement: the Japan environment and Children’s study pilot. (2017)
  • Author(s): Tsuji M, Ayabe T, Tanaka R, Senj A, Shibata E, Araki S, Morokuma S, Sanefuji M, Kusuhara K, Kawamoto T.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 22 Issue: 1 Pages: 28-28
  • DOI: 10.1186/s12199-017-0632-9
  • NAID: 210000130200
  • Peer Reviewed / Open Access
• [Journal Article] Sustained endocrine profiles of a girl with WAGR syndrome (2017)
  • Author(s): Takada Yui、Sakai Yasunari、Matsushita Yuki、Ohkubo Kazuhiro、Koga Yuhki、Akamine Satoshi、Torio Michiko、Ishizaki Yoshito、Sanefuji Masafumi、Torisu Hiroyuki、Shaw Chad A.、Kagami Masayo、Hara Toshiro、Ohga Shouichi
  • Journal Title: BMC Medical Genetics Volume: 18 Issue: 1 Pages: 117-117
  • DOI: 10.1186/s12881-017-0477-5
  • Peer Reviewed / Open Access
• [Journal Article] A childhood-onset intestinal toxemia botulism during chemotherapy for relapsed acute leukemia (2017)
  • Author(s): Ohyama Noriko、Torio Michiko、Nakashima Kentaro、Koga Yuuki、Kanno Shunsuke、Nishio Hisanori、Nishiyama Kei、Sasazuki Momoko、Kato Haru、Asakura Hiroshi、Akamine Satoshi、Sanefuji Masafumi、Ishizaki Yoshito、Sakai Yasunari、Ohga Shouichi
  • Journal Title: Annals of Clinical Microbiology and Antimicrobials Volume: 16 Issue: 1 Pages: 61-61
  • DOI: 10.1186/s12941-017-0240-y
  • Peer Reviewed / Open Access
• [Journal Article] Regional differences in infant 25-Hydroxyvitamin D: Pilot study of the Japan Environment and Children’s Study (2017)
  • Author(s): Ayabe T、Yamamoto-Hanada K、Mezawa H、Konishi M、Ishitsuka K、Saito M、Fukami M、Michikawa T、Yamazaki S、Senju A、Kusuhara K、Kawamoto T、Sanefuji M、Kato K、Oda M、Mitsubuchi H、Katoh T、Monden Y、Mise N、Kayama F、Saito H、Ohya Y
  • Journal Title: Pediatrics International Volume: 60 Issue: 1 Pages: 30-34
  • DOI: 10.1111/ped.13410
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Maternal sleep and small for gestational age infants in the Japan Environment and Children’s Study: a cohort study (2017)
  • Author(s): Morokuma Seiichi、Japan Environment & Children’s Study Group、Shimokawa Mototsugu、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Senju Ayako、Kawamoto Toshihiro、Kusuhara Koichi
  • Journal Title: BMC Research Notes Volume: 10 Issue: 1 Pages: 394-394
  • DOI: 10.1186/s13104-017-2675-9
  • Peer Reviewed / Open Access
• [Journal Article] Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion. (2017)
  • Author(s): Ichimiya Y, Kaku N, Sakai Y, Yamashita F, Matsuoka W, Muraoka M, Akamine S, Mizuguchi S, Torio M, Motomura Y, Hirata Y, Ishizaki Y, Sanefuji M, Torisu H, Takada H, Maehara Y, Ohga S.
  • Journal Title: Brain Dev. Volume: - Issue: 7 Pages: 621-624
  • DOI: 10.1016/j.braindev.2017.03.023
  • Peer Reviewed
• [Journal Article] Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome (2017)
  • Author(s): Eri Imagawa, Ken Higashimoto, Yasunari Sakai, Chikahiko Numakura, Nobuhiko Okamoto, Satoko Matsunaga, Akihide Ryo, Yoshinori Sato, Masafumi Sanefuji, Kenji Ihara, Yui Takada, Gen Nishimura, Hirotomo Saitsu, Takeshi Mizuguchi, Satoko Miyatake, Mitsuko Nakashima, Noriko Miyake, Hidenobu Soejima, Naomichi Matsumoto
  • Journal Title: Human Mutation Volume: 印刷中 Issue: 6 Pages: 637-648
  • DOI: 10.1002/humu.23200
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study (2017)
  • Author(s): Sanefuji M, Craig M, Parlatini V, Mehta MA, Murphy DG, Catani M, Cerliani L, Thiebaut de Schotten M
  • Journal Title: Cortex Volume: 86 Pages: 290-302
  • DOI: 10.1016/j.cortex.2016.06.005
  • Peer Reviewed
• [Journal Article] Involuntary movements and coma as the prognostic marker for acute encephalopathy with biphasic seizures and late reduced diffusion (2016)
  • Author(s): Lee S, Sanefuji M, Torio M, Kaku N, Ichimiya Y, Mizuguchi S, Baba H, Sakai Y, Ishizaki Y, Torisu H, Kira R Hara T, Ohga S
  • Journal Title: J Neurol Sci Volume: 370 Pages: 39-43
  • DOI: 10.1016/j.jns.2016.09.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children's Study (JECS). (2016)
  • Author(s): Morokuma S, Shimokawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A, Kawamoto T, Kusuhara K; Japan Environment & Children’s Study Group..
  • Journal Title: BMC Pregnancy Childbirth. Volume: 26;16:247. Issue: 1 Pages: 247-247
  • DOI: 10.1186/s12884-016-1041-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Manifestations and characteristics of congenital adrenal hyperplasia-associated encephalopathy. (2016)
  • Author(s): Abe Y, Sakai T, Okumura A, Akaboshi S, Fukuda M, Haginoya K, Hamano SI, Hirano K, Kikuchi K, Kubota M, Lee S, Maegaki Y, Sanefuji M, Shimozato S, Suzuki M, Suzuki Y, Takahashi M, Watanabe K, Mizuguchi M, Yamanouchi H.
  • Journal Title: Brain and Development Volume: 38 Issue: 7 Pages: 638-647
  • DOI: 10.1016/j.braindev.2016.01.007
  • Peer Reviewed
• [Presentation] 脱力発作を示す小児てんかん～臨床像と脳波～ (2020)
  • Author(s): 實藤雅文、園田有里、鳥尾倫子、一宮優子、米元耕輔、平良遼志、酒井康成、大賀正一
  • Organizer: 第62回日本小児神経学会学術集会
• [Presentation] Simultaneous recording of electroencephalogram and eye tracker for investigation of visuospatial attention. (2019)
  • Author(s): Sanefuji M, Shiotsuka Y, Yamashita H, Sonoda Y, Torio M, Ichimiya Y, Sakai Y, Yoshida K, Iramina K, Ohga S.
  • Organizer: Neuroscience
  • Int'l Joint Research
• [Presentation] 事象関連電位を用いた、視空間注意に関するPosner課題の意味合いの検証. (2019)
  • Author(s): 實藤雅文、塩塚佳幸、山下 洋、園田有里、石崎義人、酒井康成、吉田敬子、伊良皆啓治、大賀 正一
  • Organizer: 第61回日本小児神経学会学術集会
• [Presentation] Vascular pathophysiology in development of acute encephalopathy with biphasic seizures and late reduced diffusion (2018)
  • Author(s): Masafumi Sanefuji
  • Organizer: 14th Congress of the Asian Society for Pediatric Research
  • Int'l Joint Research
• [Presentation] AESDにおける脳血液供給と病変形成部位の関連の検討 (2018)
  • Author(s): 實藤雅文
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] Hemiplegia and asymmetrical lesions in acute encephalopathy (AESD). (2017)
  • Author(s): Sanefuji M, Lee S, Torio M, Ichimiya Y, Sakai Y, Ishizaki Y, Torisu H, Sasazuki M, Akamine S, Ohga S
  • Organizer: The 59th annual meeting of the Japanese society of child neurology
• [Presentation] Perceptually-driven rightward saccades for detection of lateralized visuospatial attention system (2016)
  • Author(s): Sanefuji M, Yamashita H, Sakai Y, Katsuki D, Akamine S, Shiotsuka Y, Ishizaki Y, Iramina K, Hara T, Yoshida K
  • Organizer: Neuroscience 2016
  • Place of Presentation: San Diego
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Stimulus-driven rightward saccades for detection of asymmetrical visuospatial attention system (2016)
  • Author(s): Sanefuji M, Yamashita H, Sakai Y, Ishizaki Y, Shiotsuka Y, Katsuki D, Akamine S, Torio M, Momoko S, Iramina K, Hara T, Yoshida K
  • Organizer: The 58th annual meeting of the Japanese society of child neurology
  • Place of Presentation: 東京
  • Year and Date: 2016-06-03