A research for elucidation of mechanisms of eating disorders with pathologically reduced weight and developing novel therapy
| Project/Area Number |
16K10211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
Tanaka Satoshi 名古屋大学, 医学部附属病院, 講師 (00456675)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 摂食障害 / VBM / 生理活性物質 / 質問紙 / 肝障害 / 再栄養療法 / 神経性やせ症 / 回避・制限型食物摂取症 / 精神医学 / 飢餓 / 栄養 / 脳構造画像 / 脳神経疾患 / 食品 / 内科 / 臨床 |
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| Outline of Final Research Achievements |
In anorexic patients, 1-1) we found diffuse bulk reduction of brain MRI image and a specific lesions related with body dyssatisfaction, and 1-2) we found regional loss of cerebral volume without effect from mal-nutrition. 2) We found decline of serum IL-18 level in anorexic patients, and confirmed that its correlation with Body Mass Index disappears in patients. 3) We demonstrated that a battery of self-screening instruments and self-reported body frame cannot detect eating disorders among college students. 4) We confirmed risk factors for elevated liver enzymes during refeeding of severely malnourished patients with eating disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
１）神経性やせ症など病的やせを伴う摂食障害について、脳画像の変化と精神症状の関係・ストレス耐性との関係が疑われる血中物質IL-18の変化について調べ、摂食障害のメカニズムの一端を明らかにした。２）アンケート形式の調査を一般大学生に対して行い、摂食障害の早期発見を試みたが、この調査形式では困難であることを明らかにした。３）病的や背の状態で栄養療法を行うと生じることがある肝障害について、その原因となる要因をあきらかにし、栄養療法の方法の合理化を行った。
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] 無視されてきたダイエットと痩せすぎの危険性―痩せすぎモデル禁止法に向けて―2018
Author(s)
永田 利彦, 山下 達久, 山田 恒, 水原 祐起, 水田 一郎, 野間 俊一, 田中 聡, 崔 炯仁, 和田 良久, 岡本 百合, 鈴木 眞理, 宮岡 等
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Journal Title
精神神経学雑誌
Volume: 120
Pages: 741-751
Related Report
Peer Reviewed
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[Journal Article] Risk factors for elevated liver enzymes during refeeding of severely malnourished patients with eating disorders: a retrospective cohort study2016
Author(s)
Miho Imaeda, Satoshi Tanaka, Hiroshige Fujishiro, Saki Kato, Masatoshi Ishigami, Naoko Kawano, Hiroto Katayama, Kunihiro Kohmura, Masahiko Ando, Kazuo Nishioka, Norio Ozaki
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Journal Title
Journal of Eating Disorders
Volume: 4
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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