Identification of proteins in cerebrospinal fluid associated with characteristic brain changes of psychiatric disorders

• Project/Area Number: 16K10234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Ota Miho 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 客員研究員 (00582785)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / PET / 大うつ病性障害 / DTI / DKI / NODDI / 精神生理学

Outline of Final Research Achievements

Diffusion-weighted imaging has rapidly advanced its clinical application in the late 1990's because it can delineate hyperacute cerebral infarction. In addition, the diffusion kurtosis image that can find the subtle change of brain structure, as compared with the conventional index, was developed in recent years. We have used this diffusion kurtosis image in healthy subjects, patients with major depression, and patients with bipolar disorder and clarify the disease-specific regional brain changes.
In addition, we evaluated the change of brain inflammation in major depressive disorder model rats using with [11C] (R)-[1-(2-Chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide], and the differences before and after modeling for depression were clarified by positron emission tomography (PET).

Academic Significance and Societal Importance of the Research Achievements

今回注目した拡散尖度画像は被験者に対する侵襲もほとんどなく、安定で量的な測定が可能である。脳形態画像情報という中間表現系の検討することで、精神疾患に特徴的に生じた変化が発症の原因および経過の何れと関連するプロセスなのかを今後あきらかにできるものと考える。さらに、positron emission tomographyのような精神疾患モデル動物を対象としたin vivoでの評価系が確立されれば、新規の抗精神病薬の開発などにおいて非常に有益と考えられる。

Research Products

• [Journal Article] The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in bipolar disorder. (2019)
  • Author(s): Ota M, Noda T, Sato N, Hidese S, Teraishi T, Setoyama S, Matsuda H, Kunugi H.
  • Journal Title: J Affect Disord Volume: 251 Pages: 231-234
  • DOI: 10.1016/j.jad.2019.03.068
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole brain analyses of age-related microstructural changes quantified using different diffusional magnetic resonance imaging methods. (2017)
  • Author(s): Ota M, Sato N, Maikusa N, Sone D, Matsuda H, Kunugi H.
  • Journal Title: Jpn J Radiol. Volume: 35 Issue: 10 Pages: 584-589
  • DOI: 10.1007/s11604-017-0670-7
  • Peer Reviewed
• [Journal Article] The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder. (2017)
  • Author(s): Ota M, Noda T, Sato N, Hidese S, Teraishi T, Setoyama S, Sone D, Matsuda H, Kunugi H.
  • Journal Title: J Psychiatr Res Volume: 98 Pages: 22-29
  • DOI: 10.1016/j.jpsychires.2017.12.011
  • Peer Reviewed
• [Presentation] The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder (2018)
  • Author(s): Miho Ota, Takamasa Noda, Noriko Sato, Hiroshi Matsuda, Hiroshi Kunugi
  • Organizer: The Joint Congress of the 40th Annual Meeting of Japanese Society of Biological Psychiatry and the 61th Annual Meeting of the Japanese Society for Neurochemistry