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Novel production of Cu-67 for cancer therapy using fast neutrons generated by the irradiation of deuterons

Research Project

Project/Area Number 16K10374
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

HASHIMOTO Kazuyuki  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (80414530)

Co-Investigator(Kenkyū-buntansha) 飯田 靖彦  鈴鹿医療科学大学, 薬学部, 教授 (60252425)
Research Collaborator NAGAI Yasuki  
TSUKADA Kazuaki  
SUGO Yumi  
KAWABATA Masako  
SAEKI Hideya  
OHTA Akio  
MOTOISHI Shoji  
SATO Shunichi  
FUJISAWA Yutaka  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsRI製造 / 加速器 / 中性子 / がん治療 / 銅67 / 核医学 / 無機工業化学 / 量子ビーム / 癌 / 薬学
Outline of Final Research Achievements

Copper-67 is an attractive radionuclide for cancer therapy, because of emissions of medium energy beta particle and gamma rays suitable for imaging. However, the use of Cu-67 in clinical research has been limited due to the difficulty in obtaining a sufficient amount of Cu-67. In this study, we have investigated the production of Cu-67 by the Zn-68(n,x)Cu-67 (x=n’p or d)reaction using fast neutrons from the nat-Be(d,n) or nat-C(d,n) reaction. The highly-purified Cu-67 was obtained from an irradiated Zn-68 oxide sample by the combination of dry thermochromatography and three wet column chromatography (cation exchange resin, chelate resin and anion exchange resin). Furthermore, it was estimated that the specific radioactivity of Cu-67 produced with an accelerator capable of 40 MeV, 2 mA deuteron beams is quite higher than that produced so far with a proton beams.

Academic Significance and Societal Importance of the Research Achievements

本研究成果の学術的意義は、新しい放射性同位元素(RI)製造法である加速器中性子を利用した基礎研究の成果を踏まえ、量及び質、共に臨床応用に応えられる実用レベルのCu-67製造法システムの基盤技術を確立させた点にある。
Cu-67製造・分離システムの基盤技術の確立により、Cu-67の実用化及び国産化へ一歩近づいたと言える。今後、加速器の整備等を図ることにより研究に必要なCu-67の製造を可能にし、Cu-67を用いた放射性薬剤開発の速やかな進展に大きく寄与するとともに、医療用RI医薬品の多くが海外で開発されてきた中で、国産初の新規治療用放射性医薬品の開発に資する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Application of 67Cu Produced by 68Zn(n,n'p+d)67Cu to Biodistribution Study in Tumor-Bearing Mice2017

    • Author(s)
      Y. Sugo, K. Hashimoto, M. Kawabata, H. Saeki, S. Sato, K. Tsukada, and Y. Nagai
    • Journal Title

      J. Phys. Soc. Jpn.

      Volume: 86 Issue: 2 Pages: 023201-023201

    • DOI

      10.7566/jpsj.86.023201

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 熱分離法を用いたがん治療用67Cu製造分離法の開発2018

    • Author(s)
      太田朗生、川端方子、本石章司、佐伯秀也、橋本和幸、塚田和明、初川雄一、永井泰樹
    • Organizer
      2018日本放射化学会年会・第62回放射化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Quality control tests of 99mTc-radiopharmacuticals, biodistribution of 67CuCl2 in mice, and accelerator neutrons2018

    • Author(s)
      Yasuki Nagai, Kazuyuki Hashimoto, Masako Kawabata, Kazuaki Tsukada, Yuichi Hatsukawa, Yumi Sugo, Yuto Nakahara, Hideya Saeki, Shoji Motoishi
    • Organizer
      Annual Meeting of Society of Nuclear Medicine and Molecular Imaging (SNMMI 2018), [Philadelphia, USA]
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Productions of 99Mo and 67Cu using accelerator neutrons for domestic use2018

    • Author(s)
      Yasuki Nagai, Kazuyuki Hashimoto, Masako Kawabata, Kazuaki Tsukada, Yuichi Hatsukawa, Yumi Sugo, Hideya Saeki, Shoji Motoishi and Futoshi Minato
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine (EANM 2018), [Dusseldorf, Germany]
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経内分泌腫瘍診断/治療薬開発における新規非天然アミノ酸ATSMaaを用いたsomatostatin誘導体の物性最適化2018

    • Author(s)
      藤澤豊、飯田靖彦(鈴鹿医療大薬)
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 重陽子照射で発生する加速器中性子によって製造するがん治療用67Cuの比放射能評価2017

    • Author(s)
      橋本和幸、川端方子、佐伯秀也、佐藤俊一、塚田和明、須郷由美、永井泰樹、初川雄一、石岡典子
    • Organizer
      2017日本放射化学会年会・第61回放射化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 重陽子照射で発生する加速器中性子によって製造するがん治療用67Cu の高純度化に関する検討2016

    • Author(s)
      橋本、川端、佐伯、佐藤、塚田、須郷、永井、初川、渡辺、石岡
    • Organizer
      2016日本放射化学会年会・第60回放射化学討論会
    • Place of Presentation
      新潟大学
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 50MeV 重陽子照射で発生する高速中性子による医療用放射性核種の合成研究2016

    • Author(s)
      塚田、橋本、初川、川端、佐伯、湊、岩本、永井、須郷、渡辺、石岡
    • Organizer
      2016日本放射化学会年会・第60回放射化学討論会
    • Place of Presentation
      新潟大学
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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