Development of therapeutic response-guided radiotherapy based on dose evaluation using CBCT images

• Project/Area Number: 16K10381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Takao Seishin 北海道大学, 大学病院, 助教 (10614216)
• Co-Investigator(Kenkyū-buntansha): 宮本 直樹 北海道大学, 工学研究院, 准教授 (00552879) ; 清水 伸一 北海道大学, 医学研究院, 教授 (50463724) ; 松浦 妙子 北海道大学, 工学研究院, 准教授 (90590266)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 陽子線治療 / adaptive放射線治療 / コーンビームCT / adaptive陽子線治療 / 医学物理 / 相互作用放射線治療 / 治療効果誘導放射線治療 / Adaptive放射線治療

Outline of Final Research Achievements

In this study, we have developed the therapeutic response-guided radiotherapy technique based on the quantitative estimation of changes of therapeutic response using cone-beam CT (CBCT) images. We improved the image quality of CBCT images, calculated the water equivalent thickness in spot scanning proton beam thereapy, and established a method to estimate the treatment response from changes in the water equivalent thickness.

Academic Significance and Societal Importance of the Research Achievements

本研究では、治療の経過に伴う治療効果の変化を定量的に評価するための適切な臨床指標の導出により治療効果誘導放射線治療の基礎技術を確立させた。これにより、これまで治療者側の都合、あるいは経験に基づく判断で実施されていたAdaptive 治療を理想的に発展させた、真に患者様態の変化に適合した治療が実現する。放射線治療の更なる高精度化と高効率化につながり、その社会的意義は大きいと考えられる。

Research Products

• [Presentation] Image quality evaluation for four-dimensional cone-beam CT reconstruction using orthogonal X-ray imaging system on a gantry for proton beam therapy (2019)
  • Author(s): Yukiko Otsuka, Seishin Takao, Hideaki Ueda, Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki
  • Organizer: 第118回日本医学物理学会学術大会
• [Presentation] Examples of 4D PT implementations -PT thorax treatments at Hokkaido University- (2019)
  • Author(s): Seishin Takao
  • Organizer: 4D Treatment Workshop for Particle Therapy 2019
  • Int'l Joint Research / Invited
• [Presentation] Development of a Prediction Method for Dose-Volume Histogram of Organ at Risks for Treatment Planning in Proton Beam Therapy (2018)
  • Author(s): Yu Hiyama, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Takaaki Fujii, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
  • Organizer: 2018 AAPM Annual Meeting
  • Int'l Joint Research
• [Presentation] Development of the DVH prediction method considering dose distribution in proton therapy (2018)
  • Author(s): Yu Hiyama, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
  • Organizer: 第115回日本医学物理学会学術大会
• [Presentation] Development of an image registration method using beam path-weighted mutual information for patient setup in proton beam therapy (2017)
  • Author(s): Seishin Takao, Shotaro Kawamura, Hideaki Ueda, Taeko Matsuura, Takaaki Fujii, Shusuke Hirayama, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
  • Organizer: AAPM 59th annual meeting
  • Int'l Joint Research