Development of the sonographic guide biopsy support system of the breast MRI-detection lesion by using magnetic navigation
| Project/Area Number |
16K10480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Aichi Medical University |
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Principal Investigator |
Nakano Shogo 愛知医科大学, 医学部, 教授 (20351108)
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| Co-Investigator(Kenkyū-buntansha) |
藤井 公人 愛知医科大学, 医学部, 准教授 (00524331)
安藤 孝人 愛知医科大学, 医学部, 助教 (40634134)
高阪 絢子 愛知医科大学, 医学部, 助教 (50440748)
石口 恒男 愛知医科大学, 医学部, 教授 (70115525)
塩見 有佳子 (毛利有佳子) 愛知医科大学, 医学部, 助教 (90465576)
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| Research Collaborator |
Uematsu Takayoshi 静岡がんセンター, 乳腺画像診断科・生理検査科, 科長
Futamura Manabu 岐阜大学, 腫瘍外科, 准教授
Mizoo Taeko 岡山大学, 乳腺・内分泌外科, 医員
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | MRI-detetected lesion / MRI / ultrasound / biopsy / magnetic navigation / RVS / Ｖｎａｖ / image fusion technique / 超音波fusion技術 / MRI-detected lesion / breast cancer / Ultrasound / 乳腺画像診断 / second-look US / Non mass enhancement / Breast cancer / リアルタイムバーチャルソノグラフィ / Volume navigation / Second look US / 乳癌 / 磁気ナビゲーション / MRI検出病変 / 生検 |
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| Outline of Final Research Achievements |
Recently, image fusion technique (real-time virtual sonography: RVS / Volume navigation: Vnav) have been developed. The aim of this study was to evaluate the utility of RVS/Vnav for conventional B-mode (cB-mode) occult MRI-detected breast lesions as a prospective multicenter study. 32 patients who had cB-mode occult MRI-detected lesions were enrolled. After acquisition of informed consent, an additional supine MRI was performed. Targeted US using RVS/Vnav was performed after the re-try of targeted US alone. The pathological findings were confirmed by a RVS/Vnav-guided biopsy. Of the 32 lesions, one (3%) was detected with re-try targeted US alone, whereas 30 (94%) were detected with targeted US using RVS/Vnav (p<0.0001). The success rate of tissue sampling was 75% (24/32). Of the 24 lesions, 3(13%) were DCIS and 2(8%) were invasive ductal carcinomas. Our results suggest that RVS/Vnav-guided biopsy increases the rate of tissue sampling for cB-mode occult MRI-detected lesions.
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| Academic Significance and Societal Importance of the Research Achievements |
RVS/VnavはMRI偶発病変の多くを検出できる革新的な画像診断法であり世界に発信しうる独創的な新技術であることを臨床試験で検証できた。通常の超音波では見つからないMRI偶発病変はMRIガイド下生検でしか組織検査を行うことができない。RVS/Vnavを用いることで、MRIガイド下生検に比べ検査時間も短く、高磁場の暴露もなく、より簡便に超音波ガイド下に組織生検を行うことができ、医師、患者の負担を軽減することが可能となる。またMRIガイド下生検が必要な症例をより厳選することが可能となる。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Pre-Operative Planning Using Real-Time Virtual Sonography, an MRI/Ultrasound Image Fusion Technique, for Breast-Conserving Surgery in Patients with Non-Mass Enhancement on Breast MRI: A Preliminary Study.2018
Author(s)
Ando T, Ito Y, Ido M, Osawa M, Kousaka J, Mouri Y, Fujii K, Nakano S, Kimura J, Ishiguchi T, Watanebe R, Imai T, Fukutomi T.
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Journal Title
Ultrasound Med Biol.
Volume: in press
Issue: 7
Pages: 1364-1370
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Second-look US Using Real-time Virtual Sonography, a Coordinated Breast US and MRI System with Electromagnetic Tracking Technology: A Pilot Study.2017
Author(s)
Watanabe R, Ando T, Osawa M, Ido M, Kousaka J, Mouri Y, Fujii K, Nakano S, Kimura J, Ishiguchi T, Yoshida M, Imai T, Fukutomi T.
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Journal Title
Ultrasound Med Biol.
Volume: 43
Issue: 10
Pages: 2362-2371
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Real-time virtual sonography, a coordinated sonography and MRI/CT system, for localization of parathyroid gland in patients with hyperparathyroidism. A Pilot study2018
Author(s)
S. Nakano, K. Fujii, J. Kousaka, Y. Mouri, T. Ando, M. Ido, Goto, Y. Ito,
Organizer
Congress of the Asian Association of Endocrine Surgeons
Related Report
Int'l Joint Research
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[Presentation] 乳房MRI-detected lesion検出における超音波fusion技術のsecond-look USへの応用 多施設共同研究(FUSION01)2017
Author(s)
中野 正吾, 植松 孝悦, 二村 学, 溝尾 妙子, 明石 定子, 吉田 美和, 磯本 一郎, 佐竹 弘子, 山本 滋, 高橋 麻衣子, 榊原 雅裕
Organizer
日本乳癌学会総会 25回
Related Report
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