| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we developed a detecting method of F. nucleatum, targeting nusG, using real-time PCR. We examined the clinicopathological, molecular characteristics, and prognostic effect of the tumor with F. nucleatum (+) tumors, compared to those without. In a total of 115 cases with gastroesophageal adenocarcinoma, F. nucleatum was detected in 40 cases (34.8%). We analyzed factors like gender, age, tumor location, H pylori infection status by gastroscopy, disease stage, PD-L1 expression on tumor cells, intra-/peri-tumoral CD8(+) lymphocyte infiltration, intra-/peri-tumoral FOP3(+) lymphocyte infiltration, EBV infection, MSI status, Ki-67 intensity, TP53 mutation, HER2 status, LINE-1 methylation level, and CpG methylator phenotype (by using MGMT, CHFR, and CDKN2A). However, there was no significant differences. We could not find any prognostic difference between the two, in disease-specific survival, time to recurrence, relapse-free survival, or overall-survival.
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