Development of biomarker for detection of lymphnode metastasis and prediction of recurrence in colorectal cancer using CAGE analysis

• Project/Area Number: 16K10552
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Juntendo University
• Principal Investigator: Okuzawa Atsushi 順天堂大学, 革新的医療技術開発研究センター, 先任准教授 (00348913)
• Co-Investigator(Kenkyū-buntansha): 小見山 博光 順天堂大学, 医学部, 非常勤講師 (30348982) ; 加藤 俊介 順天堂大学, 医学(系)研究科(研究院), 教授 (40312657) ; 茂櫛 薫 順天堂大学, 医学(系)研究科(研究院), 非常勤講師 (60569292)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 大腸癌 / 腫瘍マーカー / リンパ節転移 / CAGE法 / 次世代シークセンサー / 網羅的解析 / 再発予測マーカー / 大腸がん / 次世代シークエンサー / 網羅的発現解析 / 癌 / 遺伝子 / トランスレーショナルリサーチ

Outline of Final Research Achievements

In this study, we aimed to identify biomarkers for colorectal cancer, especially act as lymph node metastasis markers, and as therapeutic diagnosis markers. We selected genes whose expression levels were relatively different between samples with metastasis and without metastasis, among colorectal cancer-specific genes which had been detected by our previous studies. Then we examined the effectiveness of these genes as lymph node metastasis markers or recurrence prediction marker, and we selected several genes as the marker candidates. Next, the expression level in each case candidate genes were evaluated and genes which showed higher frequency of over-expression in lymph node metastasis cases. Furthermore, we performed a comprehensive analysis of sequence mutations in the cancer tissues of patients with colorectal cancer and identified novel marker genes. From these results, we suggested new biomarker candidate genes which act as the lymph-node metastasis markers in colorectal cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究から、大腸癌がんマーカー、とくにリンパ節転移を含む転移特異的マーカー、治療診断カーカー候補の探索・特定を行い、有望な新規マーカー候補が得られた。患者の病態を追跡し、治療効果診断等への貢献が期待できる。術前の採血でリンパ節転移と再発まで予測することが可能になれば，内視鏡等など非侵襲な手術法の適応、また，術前化学療法の適応など、適切な治療法の選択が可能になる。

Research Products

• [Journal Article] Using the polymeric circulating tumor cell chip to capture circulating tumor cells in blood samples of patients with colorectal cancer (2020)
  • Author(s): Kure K, Hosoya M, Ueyama T, Fukaya M, Sugimoto K, Tomiki Y,Ohnaga T, Sakamoto K, Komiyama H.
  • Journal Title: Oncl Lett Volume: 19 Pages: 2286-2294
  • DOI: 10.3892/ol.2020.11335
  • Peer Reviewed / Open Access
• [Journal Article] Angiopoietin-2 as a prognostic factor in patients with incurable stage IV colorectal cancer. (2020)
  • Author(s): Munakata S, Ueyama T, Ishihara H, Komiyama H, Tsukamoto R, Kawai M, Takahashi M, Kojima Y, Tomiki Y,
  • Journal Title: J Gastrointest Cancer. Volume: 2020 Online ahead of print Issue: 1 Pages: 000-000
  • DOI: 10.1007/s12029-020-00392-1
  • Peer Reviewed / Open Access
• [Journal Article] Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology. (2020)
  • Author(s): Naito Y, Mishima S, Akagi K, Igarashi A, Ikeda M, Okano, S, Kato S, Takano T, Tsuchihara K, Terashima K, et al.
  • Journal Title: Int J Clin Oncol Volume: 25 Pages: 403-417
  • Peer Reviewed / Open Access
• [Journal Article] Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. (2019)
  • Author(s): Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A.
  • Journal Title: Int J Cancer Volume: 146 Issue: 9 Pages: 2547-2562
  • DOI: 10.1002/ijc.32672
  • Peer Reviewed / Open Access
• [Journal Article] 大腸癌術後肝門部リンパ節転移による閉塞性黄疸に対して胆管ステント留置後に分子標的薬併用全身化学療法を施行した1例. (2019)
  • Author(s): 雨宮 浩太, 百瀬 裕隆, 青木 順, 岡澤 裕, 水越 幸輔, 河野 眞吾, 宗像 慎也, 石山 隼, 杉本 起一, 神山 博彦, 小見山 博光, 高橋 玄, 小島 豊, 奥澤 淳司, 坂本 一博．
  • Journal Title: 癌と化学療法 Volume: 46(4) Pages: 733-735
  • Peer Reviewed
• [Journal Article] Mitochondrial ribosomal protein PTCD3 mutations cause oxidative phosphorylation defects with Leigh syndrome. (2019)
  • Author(s): Borna NN, Kishita Y, Kohda M, Lim SC, Shimura M, Wu Y, Mogushi K, Yatsuka Y, Harashima H, Hisatomi Y, Fushimi T, Ichimoto K, Murayama K, Ohtake A, Okazaki Y.
  • Journal Title: Neurogenetics Volume: 20(1) Issue: 1 Pages: 9-25
  • DOI: 10.1007/s10048-018-0561-9
  • Peer Reviewed
• [Journal Article] Comprehensive molecular characterization of liver cancer and inheritance of the phenotypic traits during tumor recurrence. (2019)
  • Author(s): Shimada S, Mogushi K, Akiyama Y, Furuyama T, Watanabe S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Tanabe M, Wands JR, Tanaka S.
  • Journal Title: EBioMedicine Volume: 40 Pages: 457-470
  • DOI: 10.1016/j.ebiom.2018.12.058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-sensitivity detection of micrometastases generated by GFP lentivirus-transduced organoids cultured from a patient-derived colon tumor. (2018)
  • Author(s): OkazawaY, Mizukoshi K, KoyamaY, Okubo S, Komiyama H, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A.
  • Journal Title: J Vis Exp Volume: 136(e57374) Issue: 136 Pages: 463-473
  • DOI: 10.3791/57374
  • Peer Reviewed / Open Access
• [Journal Article] Tumor Sidedness and Enriched Gene Groups for Efficacy of First-line Cetuximab Treatment in Metastatic Colorectal Cancer. (2018)
  • Author(s): Sunakawa Y, Mogushi K, Lenz HJ, Zhang W, Tsuji A, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Tanioka H, Negoro Y, Moran M, Astrow SH, Hsiang J, Stephens C, Fujii M, Ichikawa W.
  • Journal Title: Mol Cancer Ther. Volume: 17 Issue: 12 Pages: 2788-2795
  • DOI: 10.1158/1535-7163.mct-18-0694
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. (2018)
  • Author(s): Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
  • Journal Title: Endocr Relat Cancer Volume: 25(6) Issue: 6 Pages: 619-631
  • DOI: 10.1530/erc-17-0328
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] COQ2 variants in Parkinson's disease and multiple system atrophy. (2018)
  • Author(s): Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N.
  • Journal Title: J Neural Transm (Vienna) Volume: - Issue: 6 Pages: 938-944
  • DOI: 10.1007/s00702-018-1885-1
  • Peer Reviewed
• [Journal Article] KCTD12 is negatively regulated by Kit in gastrointestinal stromal tumors. (2018)
  • Author(s): Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M1, Kim Y, Tanabe Y, Takagi T, Hayashi T, Mogushi K, Kaneko K, Yao T, Saito T.
  • Journal Title: Oncotarget Volume: 9(43) Issue: 43 Pages: 27016-27026
  • DOI: 10.18632/oncotarget.25469
  • Peer Reviewed / Open Access
• [Journal Article] GCH1 mutations in dopa-responsive dystonia and Parkinson's disease. (2018)
  • Author(s): Yoshino H, Nishioka K, Li Y, Oji Y, Oyama G, Hatano T, Machida Y, Shimo Y, Hayashida A, Ikeda A, Mogushi K, Shibagaki Y, Hosaka A, Iwanaga H, Fujitake J, Ohi T, Miyazaki D, Sekijima Y, Oki M, Kusaka H, Fujimoto KI Ugawa Y, Funayama M, Hattori N.
  • Journal Title: Journal of Neurology Volume: 265(8) Issue: 8 Pages: 1860-1870
  • DOI: 10.1007/s00415-018-8930-8
  • Peer Reviewed / Open Access
• [Journal Article] Elucidation of inhibitory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification. (2018)
  • Author(s): Horimoto Y, Tanabe M, Kazuno S, Miura Y, Mogushi K, Sonoue H, Arakawa A, Kajino K, Kobayashi T, Saito M.
  • Journal Title: Sci Rep Volume: 8(1):7563 Issue: 1 Pages: 1-7
  • DOI: 10.1038/s41598-018-25911-w
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacological targeting of neutrophil serine proteases prevents lethality in dextran sulfate sodium (DSS)-induced colitis in mice (2018)
  • Author(s): Ro H, Munakata S, Ueyama T, Komiyama H, Takahashi M, Kojima Y, Tomiki Y, Sakamoto K
  • Journal Title: Journal of Gastrointestinal & Digestive System Volume: 8 Issue: 01 Pages: 551-551
  • DOI: 10.4172/2161-069x.1000551
  • Peer Reviewed / Open Access
• [Journal Article] High-sensitivity detection of micrometastases generated by gfp lentivirus-transduced organoids cultured from a patient-derived colon tumor (2018)
  • Author(s): Okazawa Y, Mizukoshi K, Koyama Y, Okubo S, Komiyama H, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A.
  • Journal Title: Journal of Visualized Experiments（JoVE） in press Volume: --
  • Peer Reviewed / Open Access
• [Journal Article] Propensity Score Analysis in the Comparison of Long-Term Outcomes for Locally Advanced Colon Cancer Between Laparoscopic Colectomy and Open Colectomy (2017)
  • Author(s): Sugimoto K, Sakamoto K, Ichikawa R, Kure K, Honjo K, Ro H, Takahashi R, Kawano, Niwa K, Ishiyama S, Kamiyama H, Komiyama H, Takahashi M, Kojima Y, Goto M, Okuzawa A, Ishibiki Y, Tomiki Y
  • Journal Title: Juntendo Medical Journal Volume: 63 Issue: 4 Pages: 264-272
  • DOI: 10.14789/jmj.63.264
  • NAID: 130006106309
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Minimally Invasive Surgery for Colorectal Cancer (2017)
  • Author(s): Sakamoto K, Tsukamoto R, Kawano S, Kawai M, Niwa K, Ishiyama S, Sugimoto K, Kamiyama H, Komiyama H, Takahashi M, Kojima Y, Goto M, Okuzawa A, Tomiki Y:
  • Journal Title: Juntendo Medical Journal Volume: 63 Issue: 5 Pages: 384-392
  • DOI: 10.14789/jmj.63.384
  • NAID: 130006219695
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] Salivary Chromogranin A as a Psychosomatic Stress Marker Is Suppressed in Laparoscopic Surgery Compared with Open Surgery for Colon Cancer (2017)
  • Author(s): Ishiyama S, Sakamoto K, Kamiyama H, Niwa K, Sugimoto K, Takahashi M, KojimaY, Goto M, Okuzawa A, Tomiki Y:
  • Journal Title: Juntendo Medical Journal Volume: 63 Issue: 2 Pages: 88-94
  • DOI: 10.14789/jmj.63.88
  • NAID: 130006944480
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis. (2017)
  • Author(s): Yoshida E, Terao Y, Hayashi N, Mogushi K, Arakawa A, Tanaka Y, Ito Y, Ohmiya H, Hayashizaki Y, Takeda S, Itoh M, Kawaji H.
  • Journal Title: Sci Rep Volume: 7(1):14160 Issue: 1 Pages: 1-15
  • DOI: 10.1038/s41598-017-14418-5
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of methylation and reduced expression of the quaking gene in colorectal cancer (2017)
  • Author(s): Iwata N, Ishikawa T, Okazaki S, Mogushi K, Baba H, Ishiguro M, Kobayashi H, Tanaka H, Kawano T, Sugihara K, Uetake H.
  • Journal Title: Anticancer Res Volume: 37(2) Issue: 2 Pages: 489-498
  • DOI: 10.21873/anticanres.11341
  • Peer Reviewed
• [Journal Article] An impact of Chromosome 17q deletion in the primary lesion of colorectal cancer on liver metastasis. (2016)
  • Author(s): Kawai M, Komiyama H, Hosoya M, Okubo H, Fujii T, Yokoyama N, Sato C, Ueyama T, Okuzawa A, Goto M, Kojima Y, Takahashi M, Sugimoto K, Ishiyama S, Munakata S, Ogura D, Niwa S, Tomiki Y, Ochiai T, Sakamoto K:
  • Journal Title: Oncology Letters Volume: 12(6) Issue: 6 Pages: 4773-4778
  • DOI: 10.3892/ol.2016.5271
  • Peer Reviewed / Open Access
• [Journal Article] Postoperative adjuvant chemotherapy improves survival in stage ii colon cancer ? A propensity score matching analysis (2016)
  • Author(s): Sugimoto K, Sakamoto K, Niwa K, Ishiyama S Kamiyama H, Komiyama H, Takahashi M,Kojima Y, Goto M, Tomiki Y:
  • Journal Title: Juntendo Medical Journal Volume: 62(6) Pages: 463-471
  • NAID: 130005402125
  • Peer Reviewed / Open Access
• [Journal Article] Salivary chromogranin a as a psychosomatic stress marker is suppressed in laparoscopic surgery compared with open surgery for colon cancer (2016)
  • Author(s): Ishiyama S, Sakamoto K, Kamiyama H, Niwa K, Sugimoto K, Takahashi M, Kojima Y, Goto M, Okuzawa A, Tomiki
  • Journal Title: Juntendo Medical Journal Volume: 63 Pages: 1-7
  • NAID: 130006944480
  • Peer Reviewed / Open Access
• [Journal Article] Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung (2016)
  • Author(s): Kazuya Takamochi, Hiroko Ohmiya, Masayoshi Itoh, Kaoru Mogushi, Tsuyoshi Saito, Kieko Hara, Keiko Mitani, Yasushi Kogo, Yasunari Yamanaka, Jun Kawai, Yoshihide Hayashizaki, Shiaki Oh, Kenji Suzuki, Hideya Kawaji
  • Journal Title: BMC cancer Volume: 16:760 Pages: 1-10
  • Peer Reviewed / Open Access
• [Presentation] 網羅的解析を用いた新規結腸癌診断マーカーの探索. (2019)
  • Author(s): 塚本亮一, 小見山博光, 河野眞吾, 河合雅也, 高橋玄, 小島豊, 冨木裕一, 坂本一博:
  • Organizer: 第57回日本癌治療学会学術集会, 福岡.
• [Presentation] 大腸癌における原発巣および血漿中遊離DNAのCHFR遺伝子メチル化測定の意義. (2019)
  • Author(s): 杉本起一, 百瀬裕隆, 岡澤 裕, 高橋里奈, 水越幸輔, 盧 尚志, 河合雅也, 宗像慎也, 神山博彦, 高橋 玄, 小島 豊, 冨木裕一, 福永 哲, 梶山美明, 坂本一博:
  • Organizer: 第57回日本癌治療学会学術集会, 福岡.
• [Presentation] 患者大腸癌細胞集団の中間型上皮間葉移行を介した浸潤・転移機構. (2019)
  • Author(s): 水越幸輔，岡澤 裕，波江野 洋，小山 侑，大久保捷奇，Kaidiliavi Sulidan，伊藤恭彦，小見山博光，杉本起一，小島 豊，五藤倫敏，垣生園子，樋野興夫，折茂 彰，坂本一博:
  • Organizer: 第30回日本消化器癌発生学会総会，横浜.
• [Presentation] Laparoscopic Para-Aortic Lymph Node Resection For Colorectal Cancer. (2018)
  • Author(s): Kazuhiro Sakamoto,Toshiaki Hagiwara, Hirokazu Matsuzawa, Shingo Kawano, Shinya Kawai, Koichiro Niwa, Shun Ishiyama, Kiichi Sugimoto, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Tetsu Fukunaga, Yoshiaki Kajiyama, Seiji Kawasaki
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] Complete Mesocolic Excision For Transverse Colon In Our Hospital. (2018)
  • Author(s): Shun Ishiyama, Kota Amemiya, Yuki Tsuchiya, Hirokazu Matsuzawa, Shingo Kawano, Masaya Kawai, Koichiro Niwa, Kiichi Sugimoto, Hirohiko Kamiyama, Makoto Takahashi, Hiromitsu Komiyama, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki, Tetsu Fukunaga, Yoshiaki Kajiyama, Seiji Kawasaki, Kazuhiro Sakamoto
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] Experience Of Using A Spray-Type Anti-Adhesion Barrier In Laparoscopic Surgery For Colorectal Carcinoma. (2018)
  • Author(s): Yutaka Kojima, Kazuhiro Sakamoto, Yuichi Tomiki, Michitoshi Goto, Makoto Takahashi, Hirohiko Kamiyama, Kiichi Sugimoto, Shun Ishiyama, Koichiro Niwa, Masaya Kawai, Ryoichi Tsukamoto, Shunsuke Motegi, Yurika Makino, Toshiaki Hagiwara, Seiji Kawasaki, Yoshiaki Kajiyama, Tetsu Fukunaga
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] The Feasibility Of Laparoscopic Surgery For Primary Tumor Resection In Patients With Metastatic Colorectal Cancer. (2018)
  • Author(s): Shingo Ito, Kazuhiro Sakamoto, Ryo Ohta, Yuki Tsuchiya, Hirokazu Matsuzawa, Ryoichi Tsukamoto, Shinya Munakata, Masaya Kawai, Koichiro Niwa, Shun Ishiyama, Kiichi Sugimoto, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki
  • Organizer: SAGES & CAGES 16TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, Seattle, WA, USA
  • Int'l Joint Research
• [Presentation] The Significance of Plasma p14 gene DNA Methylation in Colorectal Cancer (2018)
  • Author(s): Hirokazu Matsuzawa, Kichi Sugimoto, Shun Ishiyama, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki and Kazuhiro Sakamoto.
  • Organizer: The 29th ISUCRS Biennial Congress
  • Int'l Joint Research
• [Presentation] The Combination of TAS-102 and Bevacizumab as the third line chemotherapy for metastatic colorectal cancer (TAS-CC3 Study) (2018)
  • Author(s): H. Kamiyama, Y. Yoshida, H. Yoshida, C. Kosugi, K. Ishibashi, K. Ihara, M. Takahashi, H. Kuramochi, A. Fukazawa, H. Sonoda, K. Yoshimatsu, A. Matsuda, S. Yamaguchi, H. Ishida, S. Hasegawa, T. Yamada, K. Sakamoto, K. Koda
  • Organizer: ESMO 2018 Congress
  • Int'l Joint Research
• [Presentation] 大腸癌における血漿中遊離DNAのCHFR遺伝子メチル化測定の意義(英語) (2018)
  • Author(s): 杉本 起一, 牧野 有里香, 青木 順, 岡澤 裕, 水越 幸輔, 河合 雅也, 宗像 慎也, 石山 隼, 神山 博彦, 高橋 玄, 小島 豊, 冨木 裕一, 福永 哲, 梶山 美明, 坂本 一博
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] SLC7A1に対するモノクローナル抗体 大腸癌組織における遺伝子発現評価と,抗体の癌細胞株に対する傷害活性(Monoclonal antibodies against SLC7A1: assessment of gene expression and cytotoxicity in colorectal cancer) (2018)
  • Author(s): 深谷 緑, 小見山 博光, 杉本 起一, 神山 博彦, 益子 高, 坂本 一博
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌における循環血液中p14遺伝子DNAメチル化測定の意義 (2018)
  • Author(s): 杉本 起一, 萩原 俊昭, 神山 博彦, 高橋 玄, 小島 豊, 冨木 裕一, 福永 哲, 梶山 美明, 川崎 誠治, 坂本 一博
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] Measures for reduction of surgical site infection in laparoscopic surgery for colorectal cancer in our department. (2017)
  • Author(s): Kojima Y, Sakamoto K, Tomiki Y, Okuzawa A, Takahashi M, Kamiyama H, Ishiyama S, Sugimoto K, Niwa K, Okazawa Y, Honjo K, Ro H, Tsukamto R, Makino Y, Hagiwara T, Matsuzawa M, Tsuchiya Y, Fukunaga T, Kajiyama Y, Kawasaki S
  • Organizer: 25th EAES Frankflut Germany 14-17 June 2017
  • Int'l Joint Research
• [Presentation] Semaphorin 3C has a possibility of a new prognostic marker in colorectal cancer. (2017)
  • Author(s): Kawano S, Komiyama H, Okuzawa A, Sakamoto K et al
  • Organizer: 110th AACR, Washington DC
  • Int'l Joint Research
• [Presentation] Postoperative adjuvant chemotherapy improves survival in stage II colon cancer ? a propensity score matching analysis. (2017)
  • Author(s): Tsukamoto R, Matsuzawa M, Hagiwara T, Tsuchiya Y, Amemiya K, Motegi S, Makino Y, Kawano S, Honjo K, Kure K, Ichikawa R, Ro H, Ito S, Takahashi R, Niwa K, Ishiyama S, Sugimoto K, Kamiyama H, Takahashi M, Kojima Y, Goto M, Okuzawa A, Tomiki Y, Fukunaga T, Kajiyama Y, Kawasaki S, Sakamoto K:
  • Organizer: 110th AACR, Washington DC
  • Int'l Joint Research
• [Presentation] 患者大腸癌由来PDXおよびオルガノイドを使用した転移モデルの樹立. (2017)
  • Author(s): 水越幸輔, 岡澤 裕, 小山 侑, 大久保 捷奇, Kaidiliavi Sulidan, 伊藤恭彦, 小見山博光, 小島 豊, 五藤倫敏, 垣生園子, 樋野興夫, 折茂 彰, 坂本一博:
  • Organizer: 第28回日本消化器癌発生学会総会, 熊本
• [Presentation] 領域外リンパ節転移を伴う大腸癌に対する腹腔鏡手術の検討 (2017)
  • Author(s): 坂本一博, 牧野有里香, 茂木俊介, 塚本亮一, 河野眞吾, 丹羽浩一郎, 石山 隼, 杉本起一, 神山博彦, 小見山博光, 高橋 玄, 小島 豊, 冨木裕一, 福永 哲, 梶山美明:
  • Organizer: 第55回日本癌治療学会学術集会 横浜
• [Presentation] 残胃癌におけるゲノムワイドDNAメチル化解析 (2016)
  • Author(s): 杉本起一，伊藤智彰，折田創，櫛田知志，桜田睦，前川博，小見山博光，高橋玄，冨木裕一，坂本一博，佐藤浩一
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] Multicellular tumor clusters seed metastases in colon patientderived tumor xenografts (2016)
  • Author(s): Okubo S, Mizukoshi K, Okazawa Y, Haeno H, Komiyama H, Saeki H, Ito Y, Gotou M Watanabe S,Hino O, Sakamoto K, Orimo A
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Remarks] 順天堂大学大学院下部消化管外科学講座
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kabusyoukakan/
• [Remarks] 順天堂大学大学院 下部消化管外科学
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kabusyoukakan/
• [Remarks] 順天堂大学大学院 下部消化管外科学 （消化器外科学講座）
  • URL: https://www.juntendo.ac.jp/graduate/laboratory/labo/kabusyoukakan/