Development of Radiomics for molecular diagnosis of gliomas

• Project/Area Number: 16K10778
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka University (2018-2019); Osaka International Cancer Institute (2016-2017)
• Principal Investigator: Kinoshita Manabu 大阪大学, 医学系研究科, 講師 (40448064)
• Co-Investigator(Kenkyū-buntansha): 吉岡 芳親 大阪大学, 生命機能研究科, 特任教授(常勤) (00174897) ; 有田 英之 大阪大学, 医学系研究科, 招へい教員 (60570570) ; 金村 米博 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (80344175) ; 橋本 直哉 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90315945)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 神経膠腫 / MRI / Radiomics / IDH / 脳腫瘍 / 脳腫瘍学 / 遺伝子変異 / Radiogenomics

Outline of Final Research Achievements

We were able to develop a radiomics analyzing system for gliomas. This system allows the user to perform a radiomics analysis of gliomas quickly. Using the method developed by ourselves, we performed radiomics for 169 cases of lower-grade gliomas. We proved that the IDH mutation status of the tumor was predicted with a diagnostic accuracy of higher than 80%. Diagnostic accuracy of discriminating lower-grade gliomas into IDH mutant, IDH mutant with 1p19q codeletion and IDH wildtype was still as low as 56%. When deep learning algorism was introduced into radiomics analysis, diagnostic accuracy for identifying three subgroups of lower-grade glioma improved by 10%. Finally, we performed radiomics for 162 glioblastoma cases and identified imaging-based prognostic biomarkers independent of MGMT promoter methylation status.

Academic Significance and Societal Importance of the Research Achievements

本研究テーマを遂行することにより、①社会実装可能な脳腫瘍に対するAI支援下非侵襲分子診断技術が開発され、さらに②大規模臨床試験など臨床医学における大規模データを有効に活用することにより、脳腫瘍に限らず他の体幹部がん疾患でも放射線画像と遺伝子情報を中心としたビッグデータによる汎用性の高い実用的なAI支援下radiogenomics診断技術開発が進むことが期待される。

Research Products

• [Journal Article] T₂-FLAIR Mismatch Sign Is Caused by Long T₁ and T₂ of <i>IDH</i>-mutant, 1p19q Non-codeleted Astrocytoma (2021)
  • Author(s): Kinoshita Manabu、Uchikoshi Masato、Sakai Mio、Kanemura Yonehiro、Kishima Haruhiko、Nakanishi Katsuyuki
  • Journal Title: MRMS Volume: 未定 Issue: 1 Pages: 119-123
  • DOI: 10.2463/mrms.bc.2019-0196
  • NAID: 130007993615
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network (2019)
  • Author(s): Fukuma Ryohei、Yanagisawa Takufumi、Kinoshita Manabu、他
  • Journal Title: Sci Rep. Volume: 9 Pages: 0-0
  • DOI: 10.1038/s41598-019-56767-3
  • Peer Reviewed / Open Access
• [Journal Article] Radiomics and MGMT promoter methylation for prognostication of newly diagnosed glioblastoma (2019)
  • Author(s): Sasaki Takahiro、Kinoshita Manabu、他
  • Journal Title: Scientific reports Volume: 9 Pages: 14435-14435
  • DOI: 10.1038/s41598-019-50849-y
  • Peer Reviewed / Open Access
• [Journal Article] 11C-methionine-18F-FDG dual-PET-tracer-based target delineation of malignant glioma: evaluation of its geometrical and clinical features for planning radiation therapy. (2019)
  • Author(s): Hirata T, Kinoshita M, Tamari, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa K.
  • Journal Title: Journal of Neurosurgery Volume: 21 Pages: 1-11
  • DOI: 10.3171/2018.4.jns1859
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between normalized distributional pattern and functional outcome in patients with acute cardiogenic cerebral embolism (2019)
  • Author(s): Takagaki Masatoshi、Kinoshita Manabu、Kawaguchi Atsushi、Murasawa Akira、Nakao Kazutami、Nakamura Hajime、Kishima Haruhiko
  • Journal Title: PLOS ONE Volume: 14 Pages: 0210709-0210709
  • DOI: 10.1371/journal.pone.0210709
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma (2019)
  • Author(s): Sakata Junichi、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Nakada Mitsutoshi、Tanaka Hirotomo、Hashimoto Naoya、Kagawa Naoki、Kinoshita Manabu、Nakamizo Satoshi、Maeyama Masahiro、Nishihara Masamitsu、Hosoda Kohkichi、Kohmura Eiji
  • Journal Title: J Neuroonco Volume: 142 Pages: 241-251
  • DOI: 10.1007/s11060-019-03113-2
  • Peer Reviewed / Open Access
• [Journal Article] Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors (2019)
  • Author(s): Sonoda Yukihiko、The committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology、Yokoo Hideaki、Tanaka Shinya、Kinoshita Manabu、Nakada Mitsutoshi、Nishihara Hiroshi
  • Journal Title: Brain Tumor Pathol. Volume: in press Pages: 56-62
  • DOI: 10.1007/s10014-019-00337-y
  • Peer Reviewed
• [Journal Article] Carotid artery stenting for patients with occipital?vertebral anastomosis (2018)
  • Author(s): Kajikawa Ryuichiro、Fujinaka Toshiyuki、Nakamura Hajime、Kinoshita Manabu、Nishida Takeo、Kishima Haruhiko
  • Journal Title: Interventional Neuroradiology Volume: 25 Pages: 212-218
  • DOI: 10.1177/1591019918802924
  • Peer Reviewed
• [Journal Article] Characteristics and outcomes of elderly patients with diffuse gliomas: a multi-institutional cohort study by Kansai Molecular Diagnosis Network for CNS Tumors (2018)
  • Author(s): Sasaki Takahiro、Fukai Junya、Kodama Yoshinori、et al
  • Journal Title: J Neurooncol Volume: 140 Pages: 329-339
  • DOI: 10.1007/s11060-018-2957-7
  • Peer Reviewed / Open Access
• [Journal Article] Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas (2018)
  • Author(s): Arita Hideyuki、Kinoshita Manabu、Kawaguchi Atsushi、Takahashi Masamichi、Narita Yoshitaka、Terakawa Yuzo、Tsuyuguchi Naohiro、Okita Yoshiko、Nonaka Masahiro、Moriuchi Shusuke、Takagaki Masatoshi、Fujimoto Yasunori、et al.
  • Journal Title: Sci Rep Volume: 8 Pages: 1-10
  • DOI: 10.1038/s41598-018-30273-4
  • Peer Reviewed / Open Access
• [Journal Article] Stereotactic image?based histological analysis reveals a correlation between 11C?methionine uptake and MGMT promoter methylation in non?enhancing gliomas (2018)
  • Author(s): Okita Yoshiko、Shofuda Tomoko、Kanematsu Daisuke、Yoshioka Ema、Kodama Yoshinori、Mano Masayuki、Kinoshita Manabu、Nonaka Masahiro、Nakajima Shin、Fujinaka Toshiyuki、Kanemura Yonehiro
  • Journal Title: Oncology Letters Volume: NA Pages: 1924-1930
  • DOI: 10.3892/ol.2018.8866
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial (2018)
  • Author(s): Kayama Takamasa、Sato Shinya、Sakurada Kaori、et al
  • Journal Title: J Clin Oncol. Volume: 36 Pages: 3282-3289
  • DOI: 10.1200/jco.2018.78.6186
  • Peer Reviewed / Open Access
• [Journal Article] Enlargement of papillary glioneuronal tumor in an adult after a follow-up period of 10 years: a case report (2018)
  • Author(s): Fujita Yuya、Kinoshita Manabu、Ozaki Tomohiko、Kitamura Masanori、Nakatsuka Shin-ichi、Kanemura Yonehiro、Kishima Haruhiko
  • Journal Title: Journal of Surgical Case Reports Volume: 2018
  • DOI: 10.1093/jscr/rjy123
  • Peer Reviewed
• [Journal Article] Voxel-based lesion mapping of meningioma: a comprehensive lesion location mapping of 260 lesions (2018)
  • Author(s): Hirayama Ryuichi、Kinoshita Manabu、Arita Hideyuki、Kagawa Naoki、Kishima Haruhiko、Hashimoto Naoya、Fujimoto Yasunori、Yoshimine Toshiki
  • Journal Title: J Neurosurg Volume: ― Pages: 1707-1712
  • DOI: 10.3171/2017.3.jns17169
  • Peer Reviewed / Open Access
• [Journal Article] Coil and Single-Stent Placement for Ruptured Dissecting Aneurysm of Middle Cerebral Artery: A Case Report (2018)
  • Author(s): Ozaki Tomohiko、Nishida Takeo、Fujita Yuya、Kishima Haruhiko、Kinoshita Manabu
  • Journal Title: World Neurosurgery Volume: 113 Pages: 208-211
  • DOI: 10.1016/j.wneu.2018.02.117
  • Peer Reviewed
• [Journal Article] Influence of region-of-interest designs on quantitative measurement of multimodal imaging of MR non-enhancing gliomas (2018)
  • Author(s): Takano Koji、Kinoshita Manabu、Arita Hideyuki、Okita Yoshiko、Chiba Yasuyoshi、Kagawa Naoki、Watanabe Yoshiyuki、Shimosegawa Eku、Hatazawa Jun、Hashimoto Naoya、Fujimoto Yasunori、Kishima Haruhiko
  • Journal Title: ONCOLOGY LETTERS Volume: 15 Pages: 7934-7940
  • DOI: 10.3892/ol.2018.8319
  • Peer Reviewed / Open Access
• [Journal Article] Preservation of Motor Function After Resection of Lower-Grade Glioma at the Precentral Gyrus and Prediction by Presurgical Functional Magnetic Resonance Imaging and Magnetoencephalography (2017)
  • Author(s): Izutsu Nobuyuki、Kinoshita Manabu、Yanagisawa Takufumi、Nakanishi Katsuhiko、Sakai Mio、Kishima Haruhiko
  • Journal Title: World Neurosurgery Volume: 107
  • DOI: 10.1016/j.wneu.2017.07.152
  • Peer Reviewed
• [Journal Article] Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis. (2017)
  • Author(s): Verburg N, Hoefnagels FWA, Barkhof F, Boellaard R, Goldman S, Guo J, Heimans JJ, Hoekstra OS, Jain R, Kinoshita M, Pouwels PJW, Price SJ, Reijneveld JC, Stadlbauer A, Vandertop WP, Wesseling P, Zwinderman AH, De Witt Hamer PC.
  • Journal Title: American Journal of Neuroradiology Volume: in press Pages: 1884-1891
  • DOI: 10.3174/ajnr.a5368
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia (2017)
  • Author(s): Ozaki Tomohiko、Nakamura Hajime、Izutsu Nobuyuki、Masaie Hiroaki、Ishikawa Jun、Kinoshita Manabu
  • Journal Title: Interventional Neuroradiology Volume: 23 Pages: 527-530
  • DOI: 10.1177/1591019917710810
  • Peer Reviewed
• [Journal Article] Voxel-Based Lesion Mapping of Cryptogenic Stroke in Patients with Advanced Cancer: A Detailed Magnetic Resonance Imaging Analysis of Distribution Pattern (2017)
  • Author(s): Achiha T, Takagaki M, Oe H, Sakai M, Matsui H, Nakanishi K, Ozaki T, Fujimoto Y, Yoshimine T, Nakanishi K, Kinoshita M
  • Journal Title: Journal of Stroke & Cerebrovascular Diseases Volume: Epub ahead of print Pages: 1521-1527
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.02.038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report. (2017)
  • Author(s): Takagaki M, Kinoshita M, Nishino K, Nakano M, Adachi H, Ueno M, Kitamura M, Fujimoto Y, Tashiro K, Tomita Y, Imamura F, Yoshimine T.
  • Journal Title: Oncol Lett Volume: 13 Pages: 2085-2088
  • DOI: 10.3892/ol.2017.5677
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genome-wide DNA methylation profiles identifies primary central nervous system lymphomas as a distinct entity from systemic diffuse large B-cell lymphomas (2017)
  • Author(s): Nakamura T, Yamashita S, Fukumura K, Tanaka K, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K
  • Journal Title: Acta Neuropathologica Volume: 133 Pages: 321-324
  • DOI: 10.1007/s00401-016-1664-8
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Voxel-based lesion mapping of meningioma: A comprehensive lesion location mapping of 260 lesions (2017)
  • Author(s): Ryuichi Hirayama, Manabu Kinoshita, Hideyuki Arita, Naoki Kagawa, Haruhiko Kishima, M Naoya Hashimoto, Yasunori Fujimoto, Toshiki Yoshimine
  • Journal Title: J Neurosurg Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia (2017)
  • Author(s): Tomohiko Ozaki, Hajime Nakamura, Nobuyuki Izutsu, Hiroaki Masaie, Jun Ishikawa, Manabu Kinoshita
  • Journal Title: Interventional Neuroradiology Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas. (2016)
  • Author(s): Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T
  • Journal Title: J Neurosurgery Volume: 印刷中 Pages: 1136-1142
  • DOI: 10.3171/2015.11.jns151848
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reduction of misregistration on cerebral four-dimensional computed tomography angiography images using advanced patient motion correction reconstruction. (2016)
  • Author(s): Kunitomi Y, Arisawa A, Tsukabe A, Tanaka H, Takahashi H, Nishida T, Kinoshita M, Nakamura H, Tomiyama N.
  • Journal Title: Japanese Journal of Radiology Volume: 34 Issue: 9 Pages: 605-610
  • DOI: 10.1007/s11604-016-0563-1
  • NAID: 50010071581
  • ISSN: 1867-1071, 1867-108X
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas. (2016)
  • Author(s): Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimokawa A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Suzuki K, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, et al.
  • Journal Title: Acta Neuropathol Commun Volume: 4 Pages: 1-14
  • DOI: 10.1186/s40478-016-0351-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas. (2016)
  • Author(s): Kinoshita M, Sakai M, Arita H, Shofuda T, Chiba Y, Kagawa N, Watanabe Y, Hashimoto N, Fujimoto Y, Yoshimine T, Nakanishi K, Kanemura Y.
  • Journal Title: PLoS One. Volume: 11
  • DOI: 10.1371/journal.pone.0164268
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Feasibility of Quantification of Intracranial Aneurysm Pulsation with 4D CTA with Manual and Computer-Aided Post-Processing. (2016)
  • Author(s): Illies T, Saering D, Kinoshita M, Fujinaka T, Bester M, Fiehler J, Tomiyama N, Watanabe Y
  • Journal Title: PLoS One Volume: 11
  • DOI: 10.1371/journal.pone.0166810
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 悪性神経膠腫の「増悪」判定の意味するものとは? (2020)
  • Author(s): 木下 学
  • Organizer: 第39回医用画像学会
  • Invited
• [Presentation] グリオーマの画像診断と遺伝子解析・病理 (2020)
  • Author(s): 木下 学
  • Organizer: 第43回日本脳神経CI学会総会
  • Invited
• [Presentation] Radiomicsの展開と 大規模臨床データの利用 (2020)
  • Author(s): 木下 学
  • Organizer: 第9回 画像医療システム産業研究会
  • Invited
• [Presentation] 膠芽腫のRadiogenomics (2019)
  • Author(s): 木下 学
  • Organizer: 第39回日本脳神経外科コングレス総会
  • Invited
• [Presentation] Radiomics in Glioma (2019)
  • Author(s): 木下 学
  • Organizer: 第78回日本医学放射線学会総会
  • Invited
• [Presentation] Imapact of 11C-methionine/FDG dural tracer PET-based, compared with MRI-based target delination of malignant gliomas for radiation planning. (2018)
  • Author(s): Kinoshita M, Hirata T, Tamari K, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa
  • Organizer: Society for Neuro-onclogy (SNO) meeting
  • Int'l Joint Research
• [Presentation] Radiogenomics of 154 WHO grade 2 and 3 gliomas via machine learning and the impact of texture analysis. (2018)
  • Author(s): Kinoshita M, Arita H, Kawaguchi A, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura K, Kanemura Y
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 26th Scientific Meeting 2018
  • Int'l Joint Research
• [Presentation] 脳腫瘍に対するradiogenomics解析システムの開発と応用 (2018)
  • Author(s): 木下学、有田英之、川口 淳、高橋雅道、深井順也、石橋謙一、露口尚弘、沖田典子、成田善孝、市村幸一、金村米博
  • Organizer: 第47回日本神経放射線学会
• [Presentation] Grade2,3神経膠腫のRadiogenomics (2017)
  • Author(s): 木下 学
  • Organizer: 第40回日本脳神経CI学会総会
  • Place of Presentation: 鹿児島サンロイヤルホテル（鹿児島）
  • Year and Date: 2017-03-03
• [Presentation] 非温熱生態作用による集束超音波治療の未来 (2017)
  • Author(s): 木下 学
  • Organizer: 第56回日本定位・機能神経外科学
  • Place of Presentation: グランフロント大阪（大阪）
  • Year and Date: 2017-01-26
  • Invited
• [Presentation] 超音波の非温熱作用を用いた集束超音波による脳治療 (2017)
  • Author(s): 木下学
  • Organizer: 第16回日本超音波治療研究会
  • Invited
• [Presentation] 大規模脳腫瘍画像データの網羅的な解析を目指しRadiomics解析の開発 (2017)
  • Author(s): 木下学、有田英之、佐々木貴浩、藤田浩二、高橋雅道、成田善孝、金村米博、貴島晴彦
  • Organizer: 第76回日本脳神経外科学会学術総会
• [Presentation] 国内大規模画像コホートを用いた人工知能による Grade II-III 神経膠腫の画像分子診断 (2017)
  • Author(s): 木下学、福間良平、柳澤琢史、篠崎隆志、貴島晴彦、高橋雅道、成田善孝 、有田英之、藤本康倫、寺川雄三、露口尚弘、深井順也、沖田典子、高垣匡寿、 石橋謙一、児玉良典、埜中正博、 森内秀祐、泉本修一、中 島義和、森鑑二、正札智子、市村幸一、 金村米博
  • Organizer: 第35回日本脳腫瘍学会
• [Presentation] Radionomic analysis of WHO grade 2 and 3 gliomas with genetic subgroup prediction. (2017)
  • Author(s): Kinoshita M, Arita H, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura K, Kanemura Y
  • Organizer: Society for Neuro-onclogy (SNO) meeting.
  • Int'l Joint Research
• [Presentation] Radiogenomics of 201 WHO grade 2 and 3 gliomas (2017)
  • Author(s): Kinoshita M, Arita H, Tkahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Noanaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodoma Y, More K, Ichimura K, Kanemura Y
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 25th Scientific Meeting
  • Int'l Joint Research
• [Presentation] 神経放射線画像から見える脳腫瘍の分子病理 (2017)
  • Author(s): 木下 学
  • Organizer: 第121回東京脳腫瘍研究会
  • Place of Presentation: 東京医科大学（東京）
  • Invited
• [Presentation] 国内大規模コホートを用いたRadiogenomicsによるGrade II-III神経膠腫の画像分子診断 (2016)
  • Author(s): 木下 学、有田英之、金村米博ほか
  • Organizer: 第34回日本脳腫瘍学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2016-12-04
• [Presentation] 膠芽腫におけるTERTプロモーター変異とMGMTメチル化状態の予後因子としての意義 (2016)
  • Author(s): 有田英之、木下 学、金村米博ほか
  • Organizer: 第34回日本脳腫瘍学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2016-12-04
• [Presentation] Grade II-III神経膠腫の遺伝子変異と発生部位：国内大規模コホートRadiogenomics解析 (2016)
  • Author(s): 有田英之、木下 学、金村米博ほか
  • Organizer: 有田英之、木下 学、金村米博ほか
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2016-12-04
• [Presentation] Impact of genetic alterations on tumor locatios and lesion heterogeneity for WHO grade 2 and 3 gliomas: A voxel-based lesion mapping and image texture analysis of 201 gliomas (2016)
  • Author(s): Kinoshita M, Hideyuki Arita, Yonehiro Kanemura, et al.
  • Organizer: 2016 Society for Neuro-onclogy (SNO) meeting
  • Place of Presentation: Scottsdale, Arizona, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Radiogenomics解析を目指したWHOグレード2、 3神 経膠腫のMRIテクスチャ解析 (2016)
  • Author(s): 木下学、酒井 美緒、有田 英之、千葉 泰良,、香川尚己、 渡辺 嘉之、橋本 直哉、藤本 康倫、吉峰 俊樹,、中西 克之、金村 米博
  • Organizer: 日本脳神経外科学会第75回学術総会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2016-09-29
• [Presentation] MR based texture and location analysis of lower grade gliomas combined with genetic mutation information (2016)
  • Author(s): Kinoshita M. Hideyuki Arita, Mio Sakai, Naoki Kagawa, Yonehiro Kanemura, Yasunori Fujimoto, Katsuyuki Nakanishi, Toshiki Yoshimine
  • Organizer: International Society for Magnetic Resonance in Medicine 2016
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Book] PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL): INCIDENCE, MANAGEMENT AND OUTCOMES. (2016)
  • Author(s): Kinoshita M
  • Total Pages: 289
  • Publisher: Nova Science Pub Inc
• [Remarks] 研究内容紹介