Disease- and Deep Brain Stimulation-Related Metabolic Networks using FDG-PET in Movement disorders
| Project/Area Number |
16K10788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MURE HIDEO 徳島大学, 病院, 講師 (00624355)
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| Co-Investigator(Kenkyū-buntansha) |
梶 龍兒 徳島大学, 大学院医歯薬学研究部(医学域), 特命教授 (00214304)
森垣 龍馬 徳島大学, 病院, 助教 (70710565)
大北 真哉 徳島大学, 病院, 特任助教 (20748694)
岡崎 敏之 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (20804389)
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| Research Collaborator |
GOTO satoshi
KAJI ryuji
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ジストニア / 画像診断 / FDG-PET / パーキンソン病 / DBS / PET / functional MRI / Diffusion tensor image / 難治性運動異常症 / 脳深部刺激療法 / DTI / バイオマーカー / 脳・神経 |
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| Outline of Final Research Achievements |
he effect of deep brain stimulation (DBS) on brain networks has remained unclear in dystonia. We searched for glucose metabolism network patterns that relate to disease and DBS in patients with dystonia.Six patients with dystonia who underwent DBS surgery and 8 healthy volunteers were enrolled in this study. images were obtained pre- and post-DBS surgery in the patients. We detected a dystonia-related network pattern. This pattern comprised relative increase in the superior parietal lobule, postcentral gyrus, precentral gyrus, cingulate gyrus, and angular gyrus. Pattern expression scores were significantly higher in dystonia patients than healthy volunteers. Second pattern suggested relative increase in the postcentral gyrus in post-DBS scans, although the difference was not significant. Our results suggest that networkwide glucose metabolism in the cortical sensorimotor regions are associated with disease and effect of DBS in human dystonia.
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| Academic Significance and Societal Importance of the Research Achievements |
ジストニアは国の指定難病であるがパーキンソン病に比べると病態解明や診断法の開発は進んでおらず、その客観的診断法も確立されていない。当施設ではジストニアに対してこれまでに約100例のDBS施行例がありこれは国内有数の治療実績である。治療の標準化および治療効果向上のために、FDG-PETを中心とした脳機能イメージングによる解析を行い、客観的な指標で病態の個体差を明らかにするため 本研究でジストニア患者PET画像データを解析し全脳ネットワークレベルで検出する基盤を確立できた。ジストニアにも特異的神経ネットワークパターンが存在しDBSの予後などの客観的マーカーにすることが可能であると考える。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Phenotype variability and allelic heterogeneity in KMT2B-Associated disease.2018
Author(s)
Kawarai T, Miyamoto R, Nakagawa E, Koichihara R, Sakamoto T, Mure H, Morigaki R, Koizumi H, Oki R, Montecchiani C, Caltagirone C, Orlacchio A, Hattori A, Mashimo H, Izumi Y, Mezaki T, Kumada S, Taniguchi M, Yokochi F, Saitoh S, Goto S, Kaji R
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Journal Title
Parkinsonism Relat Disord.
Volume: 18
Pages: 30137-30138
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment2017
Author(s)
Sogabe S, Satomi J, Tada Y, Kanematsu Y, Kuwayama K, Yagi K, Yoshioka S, Mizobuchi Y, Mure H, Yamaguchi I, Abe T, Yamamoto N, Kitazato KT, Kaji R, Harada M, Nagahiro S
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Journal Title
Neuroradiology.
Volume: －
Issue: 6
Pages: 587-595
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.2017
Author(s)
Sato A, Mizobuchi Y, Nakajima K, Shono K, Fujihara T, Kageji T, Kitazato K, Matsuzaki K, Mure H, Kuwayama K, Sumi A, Saya H, Sampetrean O, Nagahirao S.
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Journal Title
J Neurooncol.
Volume: 2
Issue: 2
Pages: 231-238
DOI
NAID
Related Report
Peer Reviewed
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